Dentistry Commons^™

A Comparison Of Bond Strength Between Direct- And Indirect-Bonding Methods, Brandon James Linn, David W. Berzins, Virendra B. Dhuru, T. Gerard Bradley

School of Dentistry Faculty Research and Publications

The purpose of this study was to evaluate and compare the shear bond strength and the sites of bond failure for brackets bonded to teeth, using two indirect-bonding material protocols and a direct-bonding technique. Sixty extracted human premolars were collected and randomly divided into three groups. The direct-bonded group (group 1) used a light-cured adhesive and primer (Transbond XT). One indirect-bonded group (group 2) consisted of a chemical-cured primer (Sondhi Rapid Set) and light-cured adhesive (Transbond XT), whereas the other group (group 3) used a light-cured primer (Orthosolo) and adhesive (Enlight LV). Forty hours after bonding, the samples were debonded. …

Force To Debond Brackets From High-Fusing And Low-Fusing Porcelain Systems, Nicholas P. Ferri, Theodore Eliades, Spiros Zinelis, T. Gerard Bradley

School of Dentistry Faculty Research and Publications

The purpose of this study was to test the hypothesis that porcelain surface finishing, ie, low- and high-fusing porcelain, has an effect on the amount of force required to debond orthodontic brackets. A total of 20 high-fusing and 20 low-fusing porcelain specimens were prepared, polished, and bonded with standard edgewise brackets using a suggested porcelain bonding protocol. The brackets were debonded with a universal testing machine at shear mode. Resin removal was performed using two methods: a multifluted carbide bur with and without the use of Sof-Lex polishing discs. Representative specimens were studied under a scanning electron microscope before and …

Bond Strength Of Direct And Indirect Bonded Brackets After Thermocycling, Jacob Daub, David W. Berzins, Brandon James Linn, T. Gerard Bradley

School of Dentistry Faculty Research and Publications

Thermocycling simulates the temperature dynamics in the oral environment. With direct bonding, thermocycling reduces the bond strength of orthodontic adhesives to tooth structure. The purpose of this study was to evaluate the shear bond strengths (SBS) of one direct and two indirect bonding methods/adhesives after thermocycling. Sixty human premolars were divided into three groups. Teeth in group 1 were bonded directly with Transbond XT. Teeth in group 2 were indirect bonded with Transbond XT/Sondhi Rapid Set, which is chemically cured. Teeth in group 3 were indirect bonded with Enlight LV/Orthosolo and light cured. Each sample was thermocycled between 5°C and …

Gnathic Osteoblastoma: Clinicopathologic Review Of Seven Cases With Long-Term Follow-Up, Yeshwant B. Rawal, Francesca Angiero, Carl M. Allen, John R. Kalmar, Parish P. Sedghizadeh, Andrew M. Steinhilber

School of Dentistry Faculty Research and Publications

The clinical, radiographic and histopathologic features of seven cases of osteoblastoma of the jaw bones were analyzed. The mandible was involved in six cases and a periosteal presentation of the tumor was noted in three cases. Six tumors were symptomatic with pain being the common presentation. The radiographic appearance of the intraosseous tumors varied from well-defined radiolucencies to poorly-defined mixed lesions. A small periosteal tumor was undetectable radiographically. Histopathologically, the tumors exhibited variation in woven bone formation, osteoblastic rimming, lesional maturation as well as interaction of the tumor with surrounding host tissue. Intraosseous tumors were managed with aggressive surgical curettage …

Clinical And Experimental Applications Of Nir-Led Photobiomodulation, Kristina D. Desmet, David A. Paz, Jesse J. Corry, Janis T. Eells, Margaret T. T. Wong-Riley, Michele M. Henry, Ellen V. Buchmann, Mary P. Connelly, Julia V. Dovi, Huan Ling Liang, Diane S. Henshel, Ronnie L. Yeager, Deborah S. Millsap, Jinhwan Lim, Lisa J. Gould, Rina Das, Marti Jett, Brian D. Hodgson, David Margolis, Harry T. Whelan

School of Dentistry Faculty Research and Publications

This review presents current research on the use of far-red to near-infrared (NIR) light treatment in various in vitro and in vivo models. Low-intensity light therapy, commonly referred to as “photobiomodulation,” uses light in the far-red to near-infrared region of the spectrum (630–1000 nm) and modulates numerous cellular functions. Positive effects of NIR–light-emitting diode (LED) light treatment include acceleration of wound healing, improved recovery from ischemic injury of the heart, and attenuated degeneration of injured optic nerves by improving mitochondrial energy metabolism and production. Various in vitro and in vivo models of mitochondrial dysfunction were treated with a variety of …

Soft Tissue To Hard Tissue Advancement Ratios For Mandibular Elongation Using Distraction Osteogenesis In Children, Michael B. Melugin, Pamela R. Hanson, Christopher A. Bergstrom, William I. Schuckit, T. Gerard Bradley

School of Dentistry Faculty Research and Publications

Distraction osteogenesis is extensively used for the elongation of hypoplastic mandibles in children, yet the soft tissue profile response to this is not well understood. The pre- and posttreatment lateral cephalometric radiographs of 27 pediatric patients who underwent bilateral mandibular elongation using distraction osteogenesis were analyzed retrospectively to correlate horizontal soft tissue advancement with horizontal underlying bone advancement at B point and pogonion. Horizontal advancement (in millimeters) of bone and overlying soft tissue at these points was collected from the radiographs of each patient, and linear regression analysis was performed to determine the relationship of hard to soft tissue horizontal …

Spatially-Oriented Emr For Dental Surgery, Min Wu, Lisa J. Koenig, John Lynch, Thomas S. Wirtz

School of Dentistry Faculty Research and Publications

As digital dental images become widely available, a new Electronic MR system (EMR) will be critical for the success of applying new technology to dental care. This project is designed an image-based and spatially-oriented EMR for dental surgery. A new panoramic image-based annotation model will be developed, which will complement dental charting precisely locating specific spatial findings for each patient. A spatially-oriented, multilayered data model for dental EMR will be developed using Geographic Information System (GIS) methods. This project will explore the possibility of applying head and neck images from VHP into a spatially-oriented EMR system.

Suppression Of The Tumorigenic Phenotype In Human Oral Squamous Cell Carcinoma Cells By An Ethanol Extract Derived From Freeze-Dried Black Raspberries, Kapila A. Rodrigo, Yeshwant B. Rawal, Robert J. Renner, Steven J. Schwartz, Qingguo Tian, Peter R. Larsen, Susan R. Mallery

School of Dentistry Faculty Research and Publications

Despite focused efforts to improve therapy, 5-yr survival rates for persons with advanced-stage oral squamous cell carcinoma (SCC) remain discouragingly low. Clearly, early detection combined with strategies for local intervention, such as chemoprevention prior to SCC development, could dramatically improve clinical outcomes. Previously conducted oral cavity human chemoprevention trials, however, have provided mixed results. Although some therapies showed efficacy, they were often accompanied by either significant toxicities or circulating antiadenoviral antibodies. It is clearly apparent that identification of nontoxic, effective treatments is essential to prevent malignant transformation of oral epithelial dysplasias. This study employed cell lines isolated from human oral …

The Absence Of Cd20 Messenger Rna In Recurrent Cutaneous B-Cell Lymphoma Following Rituximab Therapy, Yeshwant B. Rawal, Gerard J. Nuovo, Gwyn E. Frambach, Pierluigi Porcu, Robert A. Baiocchi, Cynthia M. Magro

School of Dentistry Faculty Research and Publications

Background: Rituximab has been used to treat relapsed low-grade or advanced non-Hodgkin's lymphoma since 1997, targeting the CD20 antigen expressed by B cells. Single-agent rituximab therapy is safe and well tolerated. Recurrences showing a loss of CD20 expression following rituximab therapy have been reported.

Methods: Four patients with CD20-positive cutaneous B-cell lymphoma received rituximab therapy with subsequent recurrences. The biopsies were assessed for cytoplasmic CD20 expression; CD20 messenger RNA was also assessed where tissue was available.

Results: Cutaneous relapses occurring within 1.5–3 months following the last dose of rituximab were CD20 negative. In three cases, subsequent relapses showed renewed expression …

Prevention Of Periodontal Diseases, Andrew R. Dentino, Moawia M. Kassab, Erica J. Renner

School of Dentistry Faculty Research and Publications

No abstract provided.

Treatment Of The Prominent Mandibular Angle By Using A Custom Made Surgical Splint, Luis Eduardo Almeida, Kingsley Wang, Davani Costa, Marco Antonio De Oliveira Filho

School of Dentistry Faculty Research and Publications

In this case report, we would like to present an alternative surgical technique for the treatment of the bilateral prominent mandibular angles by using a custom-made resin splint (template). The prefabricated template provided a precise outline for the osteotomy, which alleviated the uncertainty of the osseous cut. Furthermore, masseter muscle myomectomy was not necessary in this case which decreased morbidity, and procedure and recovery time, while assuring a more symmetric outcome.

Presentation Of An Epithelioid Cell Histiocytoma On The Ventral Tongue, Yeshwant B. Rawal, John R. Kalmar, Brian S. Shumway, Susan R. Mallery

School of Dentistry Faculty Research and Publications

The epithelioid cell histiocytoma (ECH) is a polypoidal benign tumor of superficial connective tissue that is often diagnosed as a pyogenic granuloma. ECHs are speculated to originate from dermal dendritic subunits and are composed of 2 primary cell populations, ie, CD34⁺ primitive fibroblastic dendrocytes and factor XIIIa⁺ histiocytes. Although dendritic subunits are distributed throughout most collagenous tissues inclusive of oral mucosa, to date, all reported cases of ECH have been cutaneous lesions. ECHs' putative pathogenesis entails activation of CD34⁺ “sentinel” reserve dendrocytes, followed by an influx of histiocytes and mast cells. Juxtacrine communication increases release of wound …

Palatal Perforation Associated With Intranasal Prescription Narcotic Abuse, Wendi M. Jewers, Yeshwant B. Rawal, Carl M. Allen, John R. Kalmar, Eric Fox, Guillermo E. Chacon, Parish P. Sedghizadeh

School of Dentistry Faculty Research and Publications

Background

Palatal perforation resulting from insufflation of cocaine has been well documented. In comparison, reports of destructive orofacial lesions resulting from intranasal abuse of prescription narcotics are rare. We present the clinical and histologic findings in a case of palatal perforation arising in a patient abusing a prescription opioid drug. The patient denied any history of cocaine use but admitted to habitually crushing and snorting a hydrocodone/acetaminophen preparation.

Study design

The patient presented to our clinic seeking resolution of speech difficulties associated with an oroantral fistula. Surgical repair of the defect had been attempted unsuccessfully in the past. In addition …

Adhesive Fragment Reattachment After Orthodontic Extrusion: A Case Report, S. Burcak Cengiz, Ilken Kocadereli, H. Cem Güngör, Nil Altay

School of Dentistry Faculty Research and Publications

In the treatment of crown fractures, adhesive fragment reattachment provides a good alternative to other restorative techniques, offering several advantages. The present paper reports a case in which the treatment of a cervical crown fracture was accomplished by reattaching the tooth fragment with a flowable resin composite. Orthodontic root extrusion was performed with a modified Hawley appliance prior to fragment reattachment. The clinical and radiographic results after 2.5 years were successful.

Pilot Survey Of Oral Health-Related Quality Of Life: A Cross-Sectional Study Of Adults In Benin City, Edo State, Nigeria, Christopher Okunseri, Amit Chattopadhyay, R Iván Lugo, Colman Mcgrath

School of Dentistry Faculty Research and Publications

Background

Oral health studies conducted so far in Nigeria have documented prevalence and incidence of dental disease using traditional clinical measures. However none have investigated the use of an oral health-related quality of life (OHRQoL) instrument to document oral health outcomes. The aims of this study are: to describe how oral health affects and impacts quality of life (QoL) and to explore the association between these affects and the oral health care seeking behavior of adults in Benin City, Edo State, Nigeria.

Methods

A cross-sectional survey recruited 356 adults aged 18–64 years from two large hospital outpatient departments and from …

Structural Conformation And Leaching From In Vitro Aged And Retrieved Invisalign Appliances, Susan Schuster, George Eliades, Spiros Zinelis, Theodore Eliades, T. Gerard Bradley

School of Dentistry Faculty Research and Publications

The objectives of this study were to investigate the structure of Invisalign appliances (Align Technology, Santa Clara, Calif) after intraoral exposure, and to qualitatively and quantitatively characterize the substances leached from the aligners after accelerated in vitro aging. Samples of Invisalign appliances were randomly selected from 10 patients before intraoral placement and after retrieval, and the prepared specimens were subjected to (1) bright-field optical reflection microscopy to study the surface morphology; (2) Fourier transform infrared microspectroscopy to characterize the in vivo changes in molecular composition induced on appliance surfaces, (3) scanning electron microscopy and energy dispersive X-ray microanalysis to identify …

Post-Irradiation Leiomyosarcoma Of The Maxilla: Report Of A Case In A Patient With Prior Radiation Treatment For Retinoblastoma, Parish P. Sedghizadeh, Francesca Angiero, Carl M. Allen, John R. Kalmar, Yeshwant B. Rawal, Eric A. Albright

School of Dentistry Faculty Research and Publications

Post-irradiation sarcoma is a well-defined complication of radiation therapy, yet few reports document such lesions in the head and neck. A 30-year-old man presented for evaluation of an expansile lesion of the left posterior maxilla. His medical history was significant for a childhood ocular malignancy - unilateral retinoblastoma - which was treated with a combination of surgical enucleation of the eye and external beam radiation therapy. Biopsy of his maxillary lesion revealed a spindle cell malignancy that was morphologically and immunohistochemically consistent with a diagnosis of leiomyosarcoma. Further investigation into the case revealed that the patient had three children, every …

Exposure To The Dental Environment And Prevalence Of Respiratory Illness In Dental Student Populations, Frank A. Scannapieco, Alex W. Ho, Maris Ditolla, Casey Chen, Andrew R. Dentino

School of Dentistry Faculty Research and Publications

Objective: To determine if the prevalence of respiratory disease among dental students and dental residents varies with their exposure to the clinical dental environment.

Methods: A detailed questionnaire was administered to 817 students at 3 dental schools. The questionnaire sought information concerning demographic characteristics, school year, exposure to the dental environment and dental procedures, and history of respiratory disease. The data obtained were subjected to bivariate and multiple logistic regression analysis.

Results: Respondents reported experiencing the following respiratory conditions during the previous year: asthma (26 cases), bronchitis (11 cases), chronic lung disease (6 cases), pneumonia (5 cases) …

The Paradigm Of The Relationship Among Occlusion, Orthodontics And Temporomandibular Disorders, Jose A. Bosio

School of Dentistry Faculty Research and Publications

The relationship between occlusion, Orthodontics and temporomandibular disorders have been subject of discussions and controversies. In the past, the scientific literature stated that the temporomandibular disorders occurred due to the malocclusion, and, for its correction, an orthodontic treatment should be performed. Apparently, those theories have become obsoletes, and according to more consistent scientific articles, the relationship among these entities have been questioned. This literature review shows a possible change in the paradigm of the relationship among the three entities.

Morphology Of Root Canal Cross-Sections Of Resected Roots Of First And Second Lower Molars, Mariusz Duda, Agata Skoczek, Bartlomiej Kowal, Agnieszka Domagala

School of Dentistry Faculty Research and Publications

Precise preparation of the root canal ostium with a view to hermetical closing with retrograde root filling is an important prognostic factor determining the success of the procedure of tooth resection. Root canals interconnected with a narrow isthmus may cause problems both in endodontic treatment and in retrograde filling. The aim of this work is the research of the transverse cross-section of root canals of first and second lower molars on the resection model. The research encompasses 100 randomly selected molar teeth: 50 first and 50 second lower molars. The tooth root apexes were cut 3 mm below the apex …

Nasa Light-Emitting Diodes For The Prevention Of Oral Mucositis In Pediatric Bone Marrow Transplant Patients, Harry T. Whelan, James F. Connelly, Brian D. Hodgson, Lori Barbeau, A. Charles Post, George Bullard, Ellen V. Buchmann, Mary Kane, Noel T. Whelan, Ann Warwick, David Margolis

School of Dentistry Faculty Research and Publications

Objective: The purpose of this study was to determine the effects of prophylactic near-infrared light therapy from light-emitting diodes (LEDs) in pediatric bone marrow transplant (BMT) recipients.

Background Data: Oral mucositis (OM) is a frequent side effect of chemotherapy that leads to increased morbidity. Near-infrared light has been shown to produce biostimulatory effects in tissues, and previous results using near-infrared lasers have shown improvement in OM indices. However, LEDs may hold greater potential for clinical applications.

Materials and Methods: We recruited 32 consecutive pediatric patients undergoing myeloablative therapy in preparation for BMT. Patients were examined by two …

Mandible Cleft: Report Of A Case And Review Of The Literature, Luis Eduardo Almeida, Lucienne Ulbrich, Fabricio Togni

School of Dentistry Faculty Research and Publications

Median cleft of the lower lip and associated structures is a relatively rare condition. We report the case of a patient with mandibular cleft. Unlike other reported cases of similar disorders, there was no cleft of the lower lip. The literature on median clefts of the lower lip and mandible is reviewed, and the etiology and treatment are discussed.

Current Status Of Defensins And Their Role In Innate And Adaptive Immunity, Periathamby A. Raj, Andrew R. Dentino

School of Dentistry Faculty Research and Publications

Naturally occurring antimicrobial cationic polypeptides play a major role in innate and adaptive immunity. These polypeptides are found to be either linear and unstructured or structured through disulfide bonds. Among the structured antimicrobial polypeptides, defensins comprise a family of cysteine-rich cationic polypeptides that contribute significantly to host defense against the invasion of microorganisms in animals, humans, insects and plants. Their wide-spread occurrence in various tissues of these diverse organisms, and their importance in innate and adaptive immunity have led to their identification, isolation and characterization. A large volume of literature is available on defensins’ occurrence, structural characterization, gene expression and …

Effect Of Nasa Light-Emitting Diode Irradiation On Wound Healing, Harry T. Whelan, Robert L. Smits, Ellen V. Buchmann, Noel T. Whelan, Scott G. Turner, David A. Margolis, Vita Cevenini, Helen Stinson, Ron Ignatius, Todd Martin, Joan Cwiklinski, Alan F. Philippi, William R. Graf, Brian D. Hodgson, Lisa Gould, Mary Kane, Gina Chen, James Caviness

School of Dentistry Faculty Research and Publications

Objective: The purpose of this study was to assess the effects of hyperbaric oxygen (HBO) and near-infrared light therapy on wound healing.

Background Data: Light-emitting diodes (LED), originally developed for NASA plant growth experiments in space show promise for delivering light deep into tissues of the body to promote wound healing and human tissue growth. In this paper, we review and present our new data of LED treatment on cells grown in culture, on ischemic and diabetic wounds in rat models, and on acute and chronic wounds in humans.

Materials and Methods: In vitro and in vivo …

Two Cases Of Unusually Heavy Odontolithiasis—One Causing Trismus, Kamala G. Pillai, Yeshwant B. Rawal

School of Dentistry Faculty Research and Publications

Although dental calculus is commonly encountered in dental patients, it rarely presents in quantities as large as in the following cases.

A Retrospective Study Of Dento-Alveolar Injuries Of Children In Ankara, Turkey, Nil Altay, H. Cem Güngör

School of Dentistry Faculty Research and Publications

Information concerning age and sex distribution, etiology, types, place and extent of trauma as well as seasonal variations, time difference between traumatic injury and seeking of dental care and number of traumatic injuries was recorded retrospectively from 150 patients. The study comprised 91 boys and 59 girls representing 246 dental injuries and 332 injured teeth (72 primary and 260 permanent teeth). The most common injuries were uncomplicated crown fracture (23.57%), subluxation (15.85%), avulsion (10.16%), lateral luxation (9.75%), complicated crown fracture and intrusion (8.4% and 8.94%, respectively). The occurrence of uncomplicated crown fractures was significantly higher (PP

Nasa Light Emitting Diode Medical Applications From Deep Space To Deep Sea, Harry T. Whelan, Ellen V. Buchmann, Noel T. Whelan, Scott G. Turner, Vita Cevenini, Helen Stinson, Ron Ignatius, Todd Martin, Joan Cwiklinski, Glenn A. Meyer, Brian D. Hodgson, Lisa J. Gould, Mary P. Kane, Gina Chen, James Caviness

School of Dentistry Faculty Research and Publications

This work is supported and managed through the NASA Marshall Space Flight Center-SBIR Program. LED-technology developed for NASA plant growth experiments in space shows promise for delivering light deep into tissues of the body to promote wound healing and human tissue growth. We present the results of LED-treatment of cells grown in culture and the effects of LEDs on patients’ chronic and acute wounds. LED-technology is also biologically optimal for photodynamic therapy of cancer and we discuss our successes using LEDs in conjunction with light-activated chemotherapeutic drugs.

Large-Scale Synthesis And Functional Elements For The Antimicrobial Activity Of Defensins, Periathamby A. Raj, K. J. Antonyraj, T. Karunakaran

School of Dentistry Faculty Research and Publications

Human neutrophil defensins, and their analogues incorporating anionic, hydrophobic or cationic residues at the N- and C-termini, were synthesized by solid-phase procedures. The synthetic defensins were examined for their microbicidal activity against Candida albicans, two Gram-negative bacteria (Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis) and two Gram-positive bacteria (Streptococcus gordonii and Streptococcus mutans). The human neutrophil peptide 1 (HNP1) and HNP2 were found to be potent candidacidal agents. HNP3, which differs by one amino acid at the N-terminus of its sequence, was totally inactive. The Gram-negative bacteria A. actinomycetemcomitans and P. gingivalis and the Gram-positive bacteria S. gordonii and S. mutans were …

Pulpal Tissue In Bilateral Talon Cusps Of Primary Central Incisors: Report Of A Case, H. Cem Güngör, Nil Altay, F. Figen Kaymaz

School of Dentistry Faculty Research and Publications

Talon cusp is a tooth anomaly that affects both the primary and the permanent dentitions. However, the occurrence of this anomalous cusp is rather infrequent in the primary dentition. Only 7 cases of bilateral talon cusps affecting the primary teeth have been reported in the dental literature. This is a case report of bilateral talon cusps on primary maxillary central incisors whose histologic evaluation revealed the existence of pulpal tissue in the anomalous cusps.

The Effect Of Edta In Attachment Gain And Root Coverage, Moawia M. Kassab, Robert E. Cohen, Sebastiano Andreana, Andrew R. Dentino

School of Dentistry Faculty Research and Publications

Root surface biomodification using low pH agents such as citric acid and tetracycline has been proposed to enhance root coverage following connective tissue grafting. The authors hypothesized that root conditioning with neutral pH edetic acid would improve vertical recession depth, root surface coverage, pocket depth, and clinical attachment levels. Twenty teeth in 10 patients with Miller class I and II recession were treated with connective tissue grafting. The experimental sites received 24% edetic acid in sterile distilled water applied to the root surface for 2 minutes before grafting. Controls were pretreated with only sterile distilled water. Measurements were evaluated before …