Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Amino Acids, Peptides, and Proteins (1)
- Biochemical Phenomena, Metabolism, and Nutrition (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Cardiovascular Diseases (1)
-
- Chemistry (1)
- Diseases (1)
- Education (1)
- Endocrine System Diseases (1)
- Female Urogenital Diseases and Pregnancy Complications (1)
- Human and Clinical Nutrition (1)
- Inorganic Chemicals (1)
- Medical Education (1)
- Medical Sciences (1)
- Medicinal-Pharmaceutical Chemistry (1)
- Nutrition (1)
- Nutritional Epidemiology (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Pharmacy and Pharmaceutical Sciences (1)
- Physical Sciences and Mathematics (1)
- Public Health (1)
- Women's Health (1)
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Chemicals and Drugs
Drug-Induced Nutrient Depletion, Rodney Richmond
Drug-Induced Nutrient Depletion, Rodney Richmond
College of Pharmacy Faculty Research and Publications
No abstract provided.
Zn(Ii), Cu(Ii), Sn(Ii), And Ni(Ii) And Other Metal Cations Do Not Prevent The Aggregation Of Hiapp, Charles Hoying
Zn(Ii), Cu(Ii), Sn(Ii), And Ni(Ii) And Other Metal Cations Do Not Prevent The Aggregation Of Hiapp, Charles Hoying
Honors Thesis
The Zn(II) metal ion has been shown to interact with Islet Amyloid Polypeptide (IAPP), a protein implicated in the progression of Type II Diabetes Mellitus, in such a way as to prevent the protein from aggregating into toxic fibers. We set out to find whether other metal ions might similarly prevent IAPP aggregation. Using Thioflavin T (ThT) spectroscopic assays, which measure fluorescence of ThT upon binding to aggregated IAPP, we observed a decrease in aggregation when incubated with Zn(II), Cu(II), Ni(II), and Sn(II). Atomic Force Microscopy (AFM), which can visualize fibril formation, revealed that the metals were not inhibiting IAPP …