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2013

Benzodiazepine

Articles 1 - 3 of 3

Full-Text Articles in Chemicals and Drugs

Role Of Gamma-Aminobutyric Acid Type A (Gabaa) Receptor Subtypes In Acute Benzodiazepine Physical Dependence-Like Effects: Evidence From Squirrel Monkeys Responding Under A Schedule Of Food Presentation, Bradford D. Fischer Phd, Laura P. Texeira, Michael L. Van Linn, Ojas A. Namjoshi, James M. Cook, James K. Rowlett Apr 2013

Role Of Gamma-Aminobutyric Acid Type A (Gabaa) Receptor Subtypes In Acute Benzodiazepine Physical Dependence-Like Effects: Evidence From Squirrel Monkeys Responding Under A Schedule Of Food Presentation, Bradford D. Fischer Phd, Laura P. Texeira, Michael L. Van Linn, Ojas A. Namjoshi, James M. Cook, James K. Rowlett

Bradford Fischer

No abstract provided.

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Reinforcing Effects Of Compounds Lacking Intrinsic Efficacy At Α1 Subunit-Containing Gabaa Receptor Subtypes In Midazolam- But Not Cocaine-Experienced Rhesus Monkeys, Nina M. Shinday, Eileen K. Sawyer, Bradford D. Fischer Phd, Donna M. Platt, Stephanie C. Licata, John R. Atack, Gerard R. Dawson, David S. Reynolds, James K. Rowlett Apr 2013

Reinforcing Effects Of Compounds Lacking Intrinsic Efficacy At Α1 Subunit-Containing Gabaa Receptor Subtypes In Midazolam- But Not Cocaine-Experienced Rhesus Monkeys, Nina M. Shinday, Eileen K. Sawyer, Bradford D. Fischer Phd, Donna M. Platt, Stephanie C. Licata, John R. Atack, Gerard R. Dawson, David S. Reynolds, James K. Rowlett

Bradford Fischer

Benzodiazepines are prescribed widely but their utility is limited by unwanted side effects, including abuse potential. The mechanisms underlying the abuse-related effects of benzodiazepines are not well understood, although α1 subunit-containing GABAA receptors have been proposed to have a critical role. Here, we examine the reinforcing effects of several compounds that vary with respect to intrinsic efficacy at α2, α3, and α5 subunit-containing GABAA receptors but lack efficacy at α1 subunit-containing GABAA receptors (‘α1-sparing compounds'): MRK-623 (functional selectivity for α2/α3 subunit-containing receptors), TPA023B (functional selectivity for α …

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Combatting Dental Anxiety In Patients, Gretchen Osdoba Apr 2013

Combatting Dental Anxiety In Patients, Gretchen Osdoba

Natural Science Student Work

Dental Anxiety is a highly debilitating condition that can keep people away from the dentist and from receiving critical care. This can lead to serious medical conditions that could have easily been prevented through proper dental care. The purpose of this paper is to describe the nature of dental fear and the different treatment options available. I will focus on helpful traits of dentists and the use of psychological treatments, nitrous oxide, anti-anxiety medications, and general anesthesia to reduce this fear. I will also discuss a comparison of a psychological treatment and an anti-anxiety medication as short-term and long-term treatment …

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