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The Sesquiterpene Lactone Dehydroleucodine Triggers Senescence And Apoptosis In Association With Accumulation Of Dna Damage Markers, Valeria V. Constantino, Sabrina F. Mansilla, Juliana Speroni, Celina Amaya, Darío Cuello-Carrión, Daniel R. Ciocca, Manual A. Barbieri, Horacio A. Priestap, Vanessa Gottifredi, Luis A. Lopez
The Sesquiterpene Lactone Dehydroleucodine Triggers Senescence And Apoptosis In Association With Accumulation Of Dna Damage Markers, Valeria V. Constantino, Sabrina F. Mansilla, Juliana Speroni, Celina Amaya, Darío Cuello-Carrión, Daniel R. Ciocca, Manual A. Barbieri, Horacio A. Priestap, Vanessa Gottifredi, Luis A. Lopez
Department of Biological Sciences
Sesquiterpene lactones (SLs) are plant-derived compounds that display anti-cancer effects. Some SLs derivatives have a marked killing effect on cancer cells and have therefore reached clinical trials. Little is known regarding the mechanism of action of SLs. We studied the responses of human cancer cells exposed to various concentrations of dehydroleucodine (DhL), a SL of the guaianolide group isolated and purified from Artemisia douglasiana (Besser), a medicinal herb that is commonly used in Argentina. We demonstrate for the first time that treatment of cancer cells with DhL, promotes the accumulation of DNA damage markers such as phosphorylation of ATM and …