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Sex Differences In Mood And Anxiety-Related Outcomes In Response To Adolescent Nicotine Exposure, Tsun Hay Jason Ng
Sex Differences In Mood And Anxiety-Related Outcomes In Response To Adolescent Nicotine Exposure, Tsun Hay Jason Ng
Electronic Thesis and Dissertation Repository
Nicotine dependence is causally linked to increased risk of mood/anxiety disorders in later life. Females are reported to experience a higher prevalence of anxiety/depressive disorders and challenges in smoking cessation therapies, suggesting a potential sex-specific response to nicotine exposure and mood/anxiety disorder risk. However, pre-clinical evidence of sex-specific responses to adolescent nicotine exposure is unclear. Thus, to determine any sex differences in anxiety/depressive-related outcomes, adolescent male and female Sprague Dawley rats received nicotine (0.4 mg/kg; 3x daily) or saline injections for 10 consecutive days, followed by behavioural testing, in-vivo electrophysiology and Western Blot analyses. Our results revealed that adolescent nicotine …
Prescription Opioid Misuse And Addiction: Healthcare’S Contribution To The Opioid Epidemic And What Can Be Done About It, Emily Larsen, Katrina Ecke
Prescription Opioid Misuse And Addiction: Healthcare’S Contribution To The Opioid Epidemic And What Can Be Done About It, Emily Larsen, Katrina Ecke
Nursing | Senior Theses
Up to one in four patients undergoing prolonged opioid therapy in a primary care setting battle opioid addiction. In 2020, the CDC found that more than 16,000 deaths involving prescription opioids (limited to natural and semi-synthetic opioids and methadone) had occurred, which is equivalent to about 45 deaths per day. Opioid overdose death can be identified through three distinct waves; increased prescribing of opioids in the 1990’s began the first wave, the beginning of the second wave came in 2010 with a rapid increase in heroin related overdose deaths, and in 2013 the third wave began with a significant increase …