Chemicals and Drugs Commons^™

Investigations Involving Mononuclear And Dinuclear Transition Metal Catalysts For Photochemical Carbon Dioxide Reduction, Ansu Edwards

Honors Theses

There is currently a global energy crisis, which is in desperate need of solutions. New energy sources are required that will not pollute as much as our longstanding reliance on nonrenewable fossil fuels as an energy source. This pollution involves large amounts of greenhouse gas emissions, predominantly carbon dioxide (CO₂), that contribute to environmental problems such as climate change. In this context, a fairly recent research direction to address this problem is the development of transition metal catalysts that can convert CO₂ into reduced carbon products that can serve as chemical fuels. This work focuses on the …

Synthesis And Characterization Of Antiviral Drug Candidate Molecules Against The Respiratory Syncytial Virus, Ali Abbas Sabi

Dissertations

Abstract

Pyrrole-imidazole polyamides (PAs) are small molecules that typically develop H-bonds to bind to the minor groove of DNA. PAs are of interest because they can be designed to recognize DNA sequences. PAs have numerous biomedical applications in areas like regulation of gene expression and antimicrobial activity. Specifically, polyamide UMSL1011 (a polyamide synthesized in Dr. Bashkin's lab) inhibits replicating vesicular stomatitis virus (VSV) by binding the viral RNA inside the nucleocapsid, as indicated by research at Professor Ming Luo's lab at Georgia State University. However, some reports have revealed that polyamides have a low affinity for “simple” double-stranded RNA. Nevertheless, …