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Full-Text Articles in Chemicals and Drugs
The Role Of The Recently Deorphanized G-Protein Coupled Receptor, Gpr171, In Morphine Tolerance And Withdrawal, Leela Afrose
The Role Of The Recently Deorphanized G-Protein Coupled Receptor, Gpr171, In Morphine Tolerance And Withdrawal, Leela Afrose
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Opioid analgesics, such as morphine, represent the gold standard pain killer and the most frequently used drugs for the treatment of moderate to severe pain. Despite being a potent analgesic, morphine has unwanted and dangerous side effects with repeated use, such as tolerance and withdrawal. Tolerance is a state when a person no longer responds to a drug and a higher dose is required to achieve the same initial pain relief. Withdrawal is a set of undesirable psychological and physiological symptoms that occur after someone stops taking a drug or reduces the dose. Morphine tolerance and withdrawal play a vital …
Opioid Dependency And Its Effects On Alcohol Consumption, Emily V. Flores
Opioid Dependency And Its Effects On Alcohol Consumption, Emily V. Flores
Psychology and Counseling Theses
Previous research has found dualistic effects on alcohol consumption with low doses of buprenorphine increasing alcohol and higher doses of buprenorphine reducing alcohol consumption in rats (Ciccocioppo et al., 2006). Other existing research on naloxone treatment and alcohol consumption in opioid use has demonstrated that alcohol consumption decreases after naloxone treatment in rats (Hyytia & Sinclair, 1993). Yet, no research has been conducted on either rats or humans on the effects of buprenorphine and naloxone medication combined. The effects of opioid maintenance therapy are controversial and the relationship between alcohol consumption and opioid dependency treatment is mainly based on literature …