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Full-Text Articles in Chemicals and Drugs
Impact Of Single Nucleotide Polymorphisms On Hpa Axis Functionality In Depression, Claire Kelly
Impact Of Single Nucleotide Polymorphisms On Hpa Axis Functionality In Depression, Claire Kelly
Honors Theses
The hypothalamic-pituitary-adrenal (HPA) axis plays a primary role in stress response through the regulated secretion of the glucocorticoid hormone cortisol. Diseases of cortisol dysregulation such as Cushing’s syndrome (hypercortisolemia) and Addison’s Disease (hypocortisolemia) are both associated with depression. Based on this we, and others, have hypothesized that mutations in the genes for the glucocorticoid receptor (GR), the closely related mineralocorticoid receptor (MR), and regulatory proteins associated with cortisol or GR function may contribute to depression in the absence of hyper- or hypo-cortisolemia. Our study investigated the genotypic frequency in the clinical population of several single nucleotide polymorphisms (SNPs) that affect …
Music As A Catalyst For Altered States Of Consciousness And Peak Experiences In The Treatment Of Depression, Anxiety, And Ptsd, Paul Battles
Music As A Catalyst For Altered States Of Consciousness And Peak Experiences In The Treatment Of Depression, Anxiety, And Ptsd, Paul Battles
Expressive Therapies Capstone Theses
Abstract This paper investigates the therapeutic uses of altered states of consciousness (ASC) and peak experiences (PE) for the treatment of depression, anxiety, and post-traumatic stress disorder (PTSD), and the ways in which music can be used to facilitate or enhance these experiences. ASC’s and PE’s can help uncover hidden or repressed unconscious material and potentially change the way an individual views and interacts with his or her world. In cases of people suffering from depression, anxiety, and post-traumatic stress disorder (PTSD), these emotional, cognitive, and perceptual changes have been shown to have sometimes profound and long- lasting therapeutic effects, …