Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Other Pharmacy and Pharmaceutical Sciences (5)
- Pharmacy and Pharmaceutical Sciences (5)
- Amino Acids, Peptides, and Proteins (4)
- Medical Biochemistry (3)
- Medical Sciences (3)
-
- Medicinal and Pharmaceutical Chemistry (3)
- Diseases (2)
- Genetic Phenomena (2)
- Life Sciences (2)
- Organisms (2)
- Other Chemicals and Drugs (2)
- Animals (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biological Phenomena, Cell Phenomena, and Immunity (1)
- Cardiovascular Diseases (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Dentistry (1)
- Endodontics and Endodontology (1)
- Enzymes and Coenzymes (1)
- Genetic Processes (1)
- Health and Medical Administration (1)
- Medical Genetics (1)
- Medical Pharmacology (1)
- Organic Chemicals (1)
- Other Medical Sciences (1)
- Pharmaceutical Preparations (1)
- Keyword
-
- 14-Helical conformation (1)
- Biomimetic (assembly) (1)
- Carboxymethyl cellulose (1)
- Caveolae (1)
- Ceramic (1)
-
- Cholesterol (1)
- Collagen (1)
- Controlled Delivery (1)
- Controlled Release (1)
- Crystallization (1)
- Envelope protein E2 (1)
- Fibrosis (1)
- Film (1)
- HCV (1)
- HPLC (1)
- Lactoferrin-derived peptides (1)
- Linker (1)
- MD simulations (1)
- Nucleation & growth (1)
- PGE2 (1)
- PGI2 (1)
- Prodrugs (1)
- Protein-peptide interaction (1)
- SEM (1)
- Solution structure (1)
- Spacer (1)
- Stability (1)
- Synthesis (1)
- Targeted Drug Delivery (1)
- Thixotropy (1)
Articles 1 - 7 of 7
Full-Text Articles in Chemicals and Drugs
Incentives For Orphan Drug Research And Development In The United States, Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio, Sheryl L. Szeinbach, Jay Visaria
Incentives For Orphan Drug Research And Development In The United States, Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio, Sheryl L. Szeinbach, Jay Visaria
Pharmacy Faculty Articles and Research
Background: The Orphan Drug Act (1983) established several incentives to encourage the development of orphan drugs (ODs) to treat rare diseases and conditions. This study analyzed the characteristics of OD designations, approvals, sponsors, and evaluated the effective patent and market exclusivity life of orphan new molecular entities (NMEs) approved in the US between 1983 and 2007.
Methods: Primary data sources were the FDA Orange Book, the FDA Office of Orphan Drugs Development, and the US Patent and Trademark Office. Data included all orphan designations and approvals listed by the FDA and all NMEs approved by the FDA during …
Helical Peptides Derived From Lactoferrin Bind Hepatitis C Virus Envelope Protein E2, Reem Beleid, Donna Douglas, Norman Kneteman, Kamaljit Kaur
Helical Peptides Derived From Lactoferrin Bind Hepatitis C Virus Envelope Protein E2, Reem Beleid, Donna Douglas, Norman Kneteman, Kamaljit Kaur
Pharmacy Faculty Articles and Research
Hepatitis C virus is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma infecting more than 170 million people. Hepatitis C virus envelope 2 glycoprotein (E2) binds several cell‐surface molecules that act as receptor candidates mediating hepatitis C virus entry into hepatocytes. Peptides derived from human lactoferrin have been shown to bind hepatitis C virus‐E2 protein thereby preventing hepatitis C virus entry in cultured hepatocytes. In this study, starting from a 33‐residue human lactoferrin‐derived peptide, a number of biotin‐linked α‐peptides were synthesized and investigated for their E2 protein binding activity. E2 protein from hepatitis C virus genotype 1b …
Composites Comprising Cholesterol And Carboxymethyl Cellulose, Vuk Uskoković
Composites Comprising Cholesterol And Carboxymethyl Cellulose, Vuk Uskoković
Pharmacy Faculty Articles and Research
Whereby cholesterol presents one of the major fatty substances in human body, carboxymethyl cellulose is a water-soluble derivative of cellulose, the most abundant dietary fiber. Whereas on one hand in vivo precipitation of cholesterol is the major cause of atherosclerosis, dietary fibers are on the other hand known for their ability to clean the fatty plaque deposited on intestinal pathways, and prevent its build-up in other critical areas within the organism. In this work, a method for the preparation of a composite material comprising cholesterol and carboxymethyl cellulose from 1-hexanol/water biphase mixtures is reported. Specificity of the interaction between the …
Right-Handed 14-Helix In Β3-Peptides From L-Aspartic Acid Monomers, Kamaljit Kaur, Tara Sprules, Wael Soliman, Reem Beleid, Sahar Ahmed
Right-Handed 14-Helix In Β3-Peptides From L-Aspartic Acid Monomers, Kamaljit Kaur, Tara Sprules, Wael Soliman, Reem Beleid, Sahar Ahmed
Pharmacy Faculty Articles and Research
β-Peptides made from L-aspartic acid monomers form a new class of β3-peptides. Here we report the first three-dimensional NMR solution structure of a β3-hexapeptide (1) from L-aspartic acid monomers in 2,2,2-trifluoroethanol (TFE). We show that 1 forms a right-handed 14-helical structure in TFE. α-peptides from naturally occurring L-amino acids adopt a right-handed α-helix whereas β3-peptides formed from β3-amino acids derived from naturally occurring L-amino acids form left-handed 14-helices. The right-handed 14-helical conformation of 1 is a better mimic of α-peptide conformations. Using the NMR structure of 1 in TFE, we …
Synthesis And In Vitro Characterization Of Novel Dextran- Methylprednisolone Conjugates With Peptide Linkers: Effects Of Linker Length On Hydrolytic And Enzymatic Release Of Methylprednisolone And Its Peptidyl Intermediates, Suman Penugonda, Anil Kumar, Hitesh K. Agarwal, Keykavous Parang, Reza Mehvar
Synthesis And In Vitro Characterization Of Novel Dextran- Methylprednisolone Conjugates With Peptide Linkers: Effects Of Linker Length On Hydrolytic And Enzymatic Release Of Methylprednisolone And Its Peptidyl Intermediates, Suman Penugonda, Anil Kumar, Hitesh K. Agarwal, Keykavous Parang, Reza Mehvar
Pharmacy Faculty Articles and Research
To control the rate of release of methylprednisolone (MP) in lysosomes, new dextran-MP conjugates with peptide linkers were synthesized and characterized. Methylprednisolone succinate (MPS) was attached to dextran 25 kDa using linkers with 1-5 Gly residues. The release characteristics of the conjugates in pH 4.0 and 7.4 buffers, blood, liver lysosomes, and various lysosomal proteinases were determined using a size-exclusion and/or a newly developed reversed-phase HPLC method capable of simultaneous quantitation of MP, MPS, and all five possible MPS-peptidyl intermediates. We synthesized conjugates with >= 90% purity and 6.9-9.5% (w/w) degree of MP substitution. The conjugates were stable at pH …
Adenylyl Cyclase Type 6 Overexpression Selectively Enhances Ss-Adrenergic And Prostacyclin Receptor Mediated Inhibition Of Rat Cardiac Fibroblast Function Due To Co-Localization In Lipid Rafts, Xiaoqiu Liu, Muthusamy Thangavel, Shu Qiang Sun, Joseph Kaminsky, Penden Mahautmr, Jeremiah Stitham, John Hwa, Rennolds S. Ostrom
Adenylyl Cyclase Type 6 Overexpression Selectively Enhances Ss-Adrenergic And Prostacyclin Receptor Mediated Inhibition Of Rat Cardiac Fibroblast Function Due To Co-Localization In Lipid Rafts, Xiaoqiu Liu, Muthusamy Thangavel, Shu Qiang Sun, Joseph Kaminsky, Penden Mahautmr, Jeremiah Stitham, John Hwa, Rennolds S. Ostrom
Pharmacy Faculty Articles and Research
Cardiac fibroblasts produce and degrade extracellular matrix and are critical in regulating cardiac remodeling and hypertrophy. Fibroblasts are activated by factors such as transforming growth factor β and inhibited by agents that elevate 3′,5′-cyclic adenosine monophosphate (cAMP) levels. cAMP signal generation and response is known to be compartmentalized in many cell types in part through the colocalization of receptors and specific adenylyl cyclase isoforms in lipid rafts and caveolae. The present study sought to define the localization of key G protein-coupled receptors with adenylyl cyclase type 6 (AC6) in lipid rafts of rat cardiac fibroblasts and to determine if this …
Enzymatic Processing Of Amelogenin During Continuous Crystallization Of Apatite, Vuk Uskoković, M.-K. Kim, W. Li, S. Habelitz
Enzymatic Processing Of Amelogenin During Continuous Crystallization Of Apatite, Vuk Uskoković, M.-K. Kim, W. Li, S. Habelitz
Pharmacy Faculty Articles and Research
Dental enamel forms through a protein-controlled mineralization and enzymatic degradation with a nanoscale precision that new engineering technologies may be able to mimic. Recombinant fulllength human amelogenin (rH174) and a matrix-metalloprotease (MMP-20) were employed in a pHstat titration system that enabled a continuous supply of calcium and phosphate ions over several days, mimicking the initial stages of matrix processing and crystallization in enamel in-vitro. Effects on the self-assembly and crystal growth from a saturated aqueous solution containing 0.4 mg/ml rH174 and MMP-20 with the weight ratio of 1:1000 with respect to rH174 were investigated. A transition from nanospheres to fibrous …