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Protein-Bound Uremic Toxins Lowering Effect Of Sevelamer In Pre-Dialysis Chronic Kidney Disease Patients With Hyperphosphatemia: A Randomized Controlled Trial, Kullaya Takkavatakarn
Protein-Bound Uremic Toxins Lowering Effect Of Sevelamer In Pre-Dialysis Chronic Kidney Disease Patients With Hyperphosphatemia: A Randomized Controlled Trial, Kullaya Takkavatakarn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: P-cresyl sulfate and indoxyl sulfate are strongly associated with cardiovascular events, and all-cause mortality in chronic kidney disease (CKD). This study was conducted to compare the effects between sevelamer and calcium carbonate on protein-bound uremic toxins in pre-dialysis CKD patients with hyperphosphatemia. Methods: After 2 weeks of the run-in period, 40 pre-dialysis CKD patients with persistent hyperphosphatemia were randomly assigned to receive either daily 2,400 mg of sevelamer or 1,500 mg of calcium carbonate for 24 weeks. Serum p-cresyl sulfate, indoxyl sulfate, fibroblast growth factor 23 (FGF23), lipid profiles, and high sensitivity C-reactive protein (hs-CRP) were evaluated. The primary …