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Stephen F. Austin State University

2019

Articles 1 - 4 of 4

Full-Text Articles in Chemicals and Drugs

Arachidin 3 Modulation Of Lipid Metabolism In Rotavirus Infections, Stormey Wisdom Jun 2019

Arachidin 3 Modulation Of Lipid Metabolism In Rotavirus Infections, Stormey Wisdom

Electronic Theses and Dissertations

Rotavirus (RV) can cause severe and deadly gastroenteritis in young children, infants, and immunocompromised individuals. Previous studies have shown that arachidin 3 (A3) inhibits RV replication, and that RV replication is dependent on the presence of lipids. This study investigated the alteration of lipid metabolism by A3 in RV infected HT29.f8 cells. A decrease in the RV regulation of lipid biosynthesis genes was observed with the addition of A3 using qRT-PCR. Also, immunofluorescent and histochemical staining for neutral fats, a major component of cellular lipid droplets, revealed an increased accumulation with both RV and RV+A3 when compared to no virus …

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Chemophobia And The Relation To Names, Justin Crow Apr 2019

Chemophobia And The Relation To Names, Justin Crow

Undergraduate Research Conference

Chemophobia is a recently identified cultural phenomena where people are afraid of chemicals in their lives, whether "chemicals" are in their food, their medicines, vaccinations, and other products. An increasing amount of people have a concern about the risk associated with chemicals in their everyday life. Chemistry professionals find this a bit strange as Chemistry states that all matter is made up of chemicals. Chemistry has many systems of naming and understanding chemicals which can exclude people from understanding the risk or lack thereof attributed to materials that are common in daily life. This effect could be accentuated by educational …

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Adhd Medication: To Medicate Or Not To Medicate?, Alyssa Henderson Apr 2019

Adhd Medication: To Medicate Or Not To Medicate?, Alyssa Henderson

Undergraduate Research Conference

Eleven percent of American children are diagnosed with at least one type of ADHD. That is 6.4 million children that are clinically diagnosed with the inability to focus attentively, restlessness, imbalanced mood swings and under-developed social skills. All of these lead to any learning environment being a daily battleground in the children both internally as well as externally. This is caused due to an under-activity in the frontal lobe of the child’s brain, which is responsible for their planning, motivation, social behavior and speech production. The symptoms associated with ADHD are currently being combated with the utilization of stimulants known …

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Breaking The Paradigm: Dr Insight Empowers Signature-Free, Enhanced Drug Repurposing, Jinyan Chan, Xuan Wang, Jacob A. Turner, Nicole E. Baldwin, Jinghua Gu Jan 2019

Breaking The Paradigm: Dr Insight Empowers Signature-Free, Enhanced Drug Repurposing, Jinyan Chan, Xuan Wang, Jacob A. Turner, Nicole E. Baldwin, Jinghua Gu

Faculty Publications

Motivation: Transcriptome-based computational drug repurposing has attracted considerable interest by bringing about faster and more cost-effective drug discovery. Nevertheless, key limitations of the current drug connectivity-mapping paradigm have been long overlooked, including the lack of effective means to determine optimal query gene signatures. Results: The novel approach Dr Insight implements a frame-breaking statistical model for the ‘hand-shake’ between disease and drug data. The genome-wide screening of concordantly expressed genes (CEGs) eliminates the need for subjective selection of query signatures, added to eliciting better proxy for potential disease-specific drug targets. Extensive comparisons on simulated and real cancer datasets have validated the …

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