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Articles 1 - 30 of 47
Full-Text Articles in Chemicals and Drugs
Does The Addition Of Muramyl Tripeptide To Chemotherapy Improve Overall Survival For Patients With Osteosarcoma?, Jennifer Jones
Does The Addition Of Muramyl Tripeptide To Chemotherapy Improve Overall Survival For Patients With Osteosarcoma?, Jennifer Jones
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Does the addition of muramyl tripeptide to chemotherapy improve overall survival for patients with osteosarcoma?”
STUDY DESIGN: Review of three English language primary randomized controlled trials published between 2005 and 2009.
DATA SOURCES: Randomized controlled trials evaluating the addition of muramyl tripeptide (MTP) to chemotherapy for patients with osteosarcoma were found using Medline/PubMed databases.
OUTCOMES MEASURED: Event-free survival (EFS) and overall survival were the outcome measures used to determine the effectiveness of the additional chemotherapy treatment in osteosarcoma patients. EFS was defined as …
Is Reduction Of Caffeine Intake Effective In Reducing The Symptoms Of Panic Attack In Panic Disorder Patients?, Elizabeth Wasson
Is Reduction Of Caffeine Intake Effective In Reducing The Symptoms Of Panic Attack In Panic Disorder Patients?, Elizabeth Wasson
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective for this selective EMB review is to determine whether or not the reduction of caffeine intake is effective in reducing the symptoms of panic attack in panic disorder patients.
STUDY DESIGN: Review of three English language randomized control trials published in 2007, 2008, and 2009.
DATA SOURCES: The double-blind placebo-controlled randomized control trials were obtained via PubMed.
OUTCOMES MEASURED: The prevalence of a clinical panic attack. Pre and post caffeine/placebo administration questionnaires were given to the participants. These surveys included the Subjective Units of Disturbance Scale (SUDS) and the Diagnostic Symptom Questionnaire (DSQ). …
Is Intravenous Ramosetron 0.3 Mg Effective In The Prevention Of Postoperative Nausea And Vomiting In Women Undergoing Gynecologic Surgery?, Keith S. Elsner
Is Intravenous Ramosetron 0.3 Mg Effective In The Prevention Of Postoperative Nausea And Vomiting In Women Undergoing Gynecologic Surgery?, Keith S. Elsner
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not intravenous ramosetron 0.3 mg is effective in the prevention of postoperative nausea and vomiting (PONV) in women undergoing gynecologic surgery.
STUDY DESIGN: Review of three English language primary research articles published later than 1995.
DATA SOURCES: Randomized, double-blinded, controlled clinical trials comparing intravenous ramosetron to placebo or other control groups were identified using Ovid MEDLINE and Cochrane Library databases.
OUTCOMES MEASURED: Measured outcomes include a complete response to the intervention within the first 24-48 hours, the incidence of postoperative nausea and vomiting, need for rescue antiemetic, …
Does Tadalafil Improve Exercise Capacitance In Patients Over 12 Years Old With Pulmonary Hypertension?, Erin Chesnavich
Does Tadalafil Improve Exercise Capacitance In Patients Over 12 Years Old With Pulmonary Hypertension?, Erin Chesnavich
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not the oral Phosphodiesterase inhibitor Tadalafil improves exercise capacitance in those over 12 years with pulmonary hypertension.
Study Design: Review of three primary research materials published in English language in 2009. Data Sources: Randomized, controlled, double blind clinical trials found using PubMed, OVID and COCHRANE databases.
Outcome measured: Trials measured 6-minute walking distance and health related quality of life measurements which included: SF-36 (a measure of self reported health status), and the EQ-5D (a patient reported health related quality of life measure), WHO functional class, clinical worsening, and …
Does The Use Of Intravenous Zoledronic Acid, In Combination With Chemotherapy Regimens, Arrest The Development And Spread Of Cancer Cells To Increase Disease-Free Survival In Breast Cancer Patients?, Dara Colasurdo
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Does the use of intravenous zoledronic acid, in combination with chemotherapy regimens, arrest the development and spread of cancer cells to increase disease-free survival in breast cancer patients.“
STUDY DESIGN: Review of three English language primary randomized controlled trials published between 2009 and 2010.
DATA SOURCES: Randomized controlled trials and open label, randomized, phase 2 trial comparing the use of zoledronic acid in combination with chemotherapy to the use of chemotherapy alone were found using Medline/PubMed and Cochrane Databases
OUTCOMES MEASURED: The outcomes measured were incidence …
Is Afrin (Oxymetazoline) A Safe And Effective Drug In Normal, Healthy Adults With Reference To Nasal Congestion And The Nasal Response?, Allie Rubinstein
Is Afrin (Oxymetazoline) A Safe And Effective Drug In Normal, Healthy Adults With Reference To Nasal Congestion And The Nasal Response?, Allie Rubinstein
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not, “Is Afrin (Oxymetazoline) a safe and effective drug in normal, healthy adults with reference to nasal congestion and the nasal response?”
STUDY DESIGN: Review of three English language primary studies published in 1997, 1999, 2003.
DATA SOURCES: Randomized, controlled studies (double-blind, placebo-controlled) testing the efficacy and safeness of Afrin in comparison to a placebo group, were found using the PubMed database.
OUTCOMES MEASURED: Nasal patency, congestion, degree of nasal blockage, and symptoms (quantity, consistency, color of nasal secretions, turbinate size/color) were measured through patient diary card …
Is Aspirin Effective In Helping To Prevent Breast Cancer In Women Ages 45 Years And Older?, Kristen M. Quartuccio
Is Aspirin Effective In Helping To Prevent Breast Cancer In Women Ages 45 Years And Older?, Kristen M. Quartuccio
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not aspirin is effective in helping to prevent breast cancer in women ages 45 years and older.
STUDY DESIGN: Review of three English language primary studies published in 2005, 2007, and 2008
DATA SOURCES: Two randomized, double blind, placebo controlled clinical trials and one prospective, population based cohort study comparing aspirin to placebo were found using PubMed and Cochrane databases.
OUTCOMES MEASURED: Breast cancer development was measured in several ways. Tumor characteristics were measured at diagnosis, including size, metastasis to lymph nodes, histology of the mass, histology …
Is Fixed-Combination Prostaglandin Analog/Β-Blocker Therapy Safe And More Effective Than Β-Blocker Monotherapy In The Prevention Of Disease Progression In Adults With Open-Angle Glaucoma?, My-Hang Pham
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this selective EBM review is to determine whether fixed-combination prostaglandin analog/β-blocker therapy is safe and more effective than β-blocker monotherapy in the prevention of disease progression in adults with open-angle glaucoma.
Study Design: Review of three English language randomized controlled trials published in 2008 and 2010.
Data sources: 3 randomized, controlled, double-blind trials comparing fixed-combination prostaglandin analog/β-blocker therapy to β-blocker monotherapy were found using Pubmed, Medline, and Cochrane databases.
Outcome Measured: Disease progression/regression was assessed by post-baseline measurement of IOP during three follow-up visits throughout the trials. The safety profile of each therapy was …
Is Tesamorelin A Safe And Effective Drug To Treat Lipodystrophy In Hiv Patients?, Jazmine A. Cole
Is Tesamorelin A Safe And Effective Drug To Treat Lipodystrophy In Hiv Patients?, Jazmine A. Cole
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this selective EBM review is to determine whether or not Tesamorelin is a safe and effective drug to treat lipodystrophy in HIV patients.
Study Design: Review of three English language primary randomized controlled trials published between 2005-2010.
Data Sources: Randomized, placebo-controlled, double-blind clinical trials comparing Tesamorelin to a visually matched placebo were found using PubMed.
Outcome(s) Measured: Each of the three clinical trials assessed the improvement of lipodystrophy (accumulation of visceral adipose tissue) in HIV patients. In addition, they noted how the improvement in lipodystrophy would impact patient's self body image and quality of life. Prior …
Does The Use Of An Oral Lipase Inhibitor (Orlistat) Increase Appetite?, Sandra Boyd
Does The Use Of An Oral Lipase Inhibitor (Orlistat) Increase Appetite?, Sandra Boyd
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: To determine whether or not Orlistat ingested prior to a meal causes an increased appetite response.
STUDY DESIGN: A Review of three randomized controlled trials studies from 2003-2008 that were in the English language.
DATA RESOURCES: Randomized controlled trials comparing the effect of Orlistat on satiety were found using PubMed, OVID, and Cochrane databases.
OUTOMES MEASURED: Outcomes measured in the studies were: sensation of appetite, hunger, fullness, nausea, bloating, heartburn, belching, epigastric burning, and prospective food consumption. Each study measured individual patient responses using a VAS (visual analogue scale). Demarchi et al (2004) used a gastric barostat to measure …
Is Asenapine More Effective Than Other Interventions In The Treatment Of Adult Patients With Bipolar I Disorder?, Mary H. Tsakiris
Is Asenapine More Effective Than Other Interventions In The Treatment Of Adult Patients With Bipolar I Disorder?, Mary H. Tsakiris
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not Asenapine is more effective than other interventions in the treatment of adult patients with bipolar I disorder.
STUDY DESIGN: Review of three English language primary randomized controlled trial studies published from 2009-2010.
DATA SOURCES: Three randomized controlled trials studying the effectiveness of Asenapine in the treatment of mania in adult patients with bipolar I disorder in comparison to other interventions.
OUTCOME MEASURED: Outcomes measured were reduction in severity of manic symptoms and tolerability of the medication. The severity of manic symptoms was measured using the Young …
Is Ceftobiprole A Safe And Effective Treatment For Skin And Skin Structure Infections?, Laura Thompson
Is Ceftobiprole A Safe And Effective Treatment For Skin And Skin Structure Infections?, Laura Thompson
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not ceftobiprole is a safe and effective treatment for complicated skin and skin structure infections
STUDY DESIGN: Review of all English language primary randomized controlled trials from 1996-2010
DATA SOURCES: Three randomized controlled trials were found using Pubmed and Cochrane databases
OUTCOMES MEASURES: Skin or skin-structure infection cure with ceftobiprole intervention and adverse effects of this new pharmaceutical. Cure or failure to cure skin infection was determined based on both clinical and microbiological assessment. Adverse events were measured based on patient reports, clinician reports, labs, and vital sign …
Is Rivastigmine Effective In The Treatment Of Alzheimer’S Disease?, Beena Patel
Is Rivastigmine Effective In The Treatment Of Alzheimer’S Disease?, Beena Patel
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not rivastigmine is effective for the treatment of Alzheimer’s Disease.
STUDY DESIGN: Review of two trials in the English language published in 2007 and 2010, and an open-label, singlearm, multi-center study from 2008.
DATA SOURCES: Randomized, double-blind, placebo-controlled trials comparing rivastigmine to a visually-matched capsule (placebo) was found using PubMed and Cochrane databases.
OUTCOMES MEASURED: Overall global performance using the Alzheimer’s Disease Assessment Scale (ADAS-cog), ability to perform activities of daily living, cognitive function using the mini mental status exam (MMSE), and neuropsychiatric symptoms using BEHAVE-AD.
RESULTS: …
Is The Use Of Apixaban Or Enoxaparin, More Effective In The Prophylaxis Of Venous Thromboembolism Post-Orthopedic Surgery?, Jolene Bohensky
Is The Use Of Apixaban Or Enoxaparin, More Effective In The Prophylaxis Of Venous Thromboembolism Post-Orthopedic Surgery?, Jolene Bohensky
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not the use of Apixaban or Enoxaparin is more effective in the prophylaxis of venous thromboembolism post-orthopedic surgery.
STUDY DESIGN: Review of three English language randomized, double-blind, placebo-controlled clinical trials from 2009-2010.
DATA SOURCES: Randomized, double-blind placebo controlled, clinical trials comparing the effectiveness of Apixaban and Enoxaparin in the prophylaxis of Venous Thromboembolism (VTE) post-orthopedic surgery were found using PubMed, the Cochrane Database of Randomized Controlled Trials, and the Cochrane Databases of Systematic Reviews.
OUTCOMES MEASURED: Development of venous thromboembolism (VTE) post-orthopedic surgery including Total …
Is Green Tea An Effective Aid In Weight Reduction?, Lindsey A. Brown
Is Green Tea An Effective Aid In Weight Reduction?, Lindsey A. Brown
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not green tea extract is effective in aiding in weight reduction.
Does Fish Oil Supplementation (Omega-3 Pufa) Cause Mood Improvement In Adults With Depression, Lauren Cabana
Does Fish Oil Supplementation (Omega-3 Pufa) Cause Mood Improvement In Adults With Depression, Lauren Cabana
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not “Does fish oil supplementation (omega-3 PUFA) cause mood improvement in adults with depression?”
Is White Bean Extract A Safe And Effective Treatment For Weight Loss?, Jamie Berkowitz
Is White Bean Extract A Safe And Effective Treatment For Weight Loss?, Jamie Berkowitz
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not white bean extract is a safe and effective treatment for weight loss.
Does Venlafaxine (Effexor) Decrease The Frequency Of Hot Flashes In Women With Breast Cancer?, Allison Berneking
Does Venlafaxine (Effexor) Decrease The Frequency Of Hot Flashes In Women With Breast Cancer?, Allison Berneking
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not “Does venlafaxine (Effexor) decrease the frequency of hot flashes in women with breast cancer?”
Does Tranexamic Acid Effectively And Safely Reduce Menstrual Blood Loss (Mbl) In Women With Menorrhagia Or Iud Induced Mbl?, Veronica W. Chang
Does Tranexamic Acid Effectively And Safely Reduce Menstrual Blood Loss (Mbl) In Women With Menorrhagia Or Iud Induced Mbl?, Veronica W. Chang
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: To determine if Tranexamic Acid effectively and safely reduce menstrual blood loss (MBL) in women with Menorrhagia or IUD induced MBL?
Is Chronic Use Of Bacopa Monnieri An Effective Treatment To Improve Memory Performance In Healthy And Aging Adults?, Brian M. Kairalla
Is Chronic Use Of Bacopa Monnieri An Effective Treatment To Improve Memory Performance In Healthy And Aging Adults?, Brian M. Kairalla
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of the systematic review is to determine whether or not chronic use of Bacopa monnieri is an effective treatment to improve memory performance in healthy and aging adults.
Is Growth Hormone An Effective Adjunct To Standard Treatment Regimens For Promoting Fat Mass Loss And Retention Of Lean Body Mass In The Treatment Of Obesity?, J. Caleb Henson
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether growth hormone is an effective adjunct in the treatment of obesity for promoting fat loss while retaining lean body mass.
Does Caffeine Consumption Effect Exercise Performance In Healthy Adults?, Meaghan E. Jones
Does Caffeine Consumption Effect Exercise Performance In Healthy Adults?, Meaghan E. Jones
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not caffeine ingestion prior to exercise effects exercise performance in healthy adults.
How Safe And Effective Is Infliximab In The Treatment Of Children With Moderate To Severe Crohn’S Disease?, Jackie Linh
How Safe And Effective Is Infliximab In The Treatment Of Children With Moderate To Severe Crohn’S Disease?, Jackie Linh
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not “how safe and effective is infliximab in treatment of children with moderate to severe Crohn’s disease?”
Is L-Carnitine An Effective Treatment To Improve The Quality Of Life For Patients With Rett Syndrome?, Bernadette Mason
Is L-Carnitine An Effective Treatment To Improve The Quality Of Life For Patients With Rett Syndrome?, Bernadette Mason
PCOM Physician Assistant Studies Student Scholarship
Objective: To determine “Is L-carnitine an effective treatment to improve the quality of life for patients with Rett Syndrome?”
Is Maternal Buprenorphine Use During Pregnancy Effective In Preventing Neonatal Abstinence Syndrome?, Danielle L. Parrott
Is Maternal Buprenorphine Use During Pregnancy Effective In Preventing Neonatal Abstinence Syndrome?, Danielle L. Parrott
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not maternal buprenorphine use during pregnancy is effective in preventing neonatal abstinence syndrome (NAS).
Is Lenalidomide, In Combination With Dexamethasone, A Safe And Effective Treatment For Relapsed Multiple Myeloma?, Sarah Moncado
Is Lenalidomide, In Combination With Dexamethasone, A Safe And Effective Treatment For Relapsed Multiple Myeloma?, Sarah Moncado
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not lenalidomide, in combination with dexamethasone, is a safe and effective treatment for relapsed multiple myeloma.
The Effectiveness And Safety Of Antibiotic Treatment In Healing Tympanic Membrane Perforation In Aboriginal Children, Shannon M. Rice
The Effectiveness And Safety Of Antibiotic Treatment In Healing Tympanic Membrane Perforation In Aboriginal Children, Shannon M. Rice
PCOM Physician Assistant Studies Student Scholarship
The objective of this systematic review is to determine whether or not antibiotic treatment is safe and effective in healing tympanic membrane (TM) perforation in Aboriginal children diagnosed with chronic suppurative otitis media and otitis media with effusion less than 16 years of age.
Is Iron Sucrose (Venofer) A Safe Treatment For People With Chronic Kidney Disease?, Kait Reid
Is Iron Sucrose (Venofer) A Safe Treatment For People With Chronic Kidney Disease?, Kait Reid
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this study is to determine if Iron Sucrose (Venofer) is a safe treatment for people with Chronic Kidney Disease.
Is Topical 1% Pimecrolimus Cream An Effective Treatment For Rosacea?, Lauren Sloan
Is Topical 1% Pimecrolimus Cream An Effective Treatment For Rosacea?, Lauren Sloan
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not topical 1% pimecrolimus cream is an effective treatment for rosacea.
Is Liraglutide Safe And Effective As A Monotherapy For The Treatment Of Obesity In Type 2 Diabetics And Healthy Individuals?, Erica Sheeran
Is Liraglutide Safe And Effective As A Monotherapy For The Treatment Of Obesity In Type 2 Diabetics And Healthy Individuals?, Erica Sheeran
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not liraglutide is safe and effective as a monotherapy for the treatment of obesity in type 2 diabetics and healthy individuals.