Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Organic Chemicals (4)
- Chemistry (3)
- Life Sciences (3)
- Lipids (3)
- Physical Sciences and Mathematics (3)
-
- Alternative and Complementary Medicine (2)
- Medical Sciences (2)
- Medicinal-Pharmaceutical Chemistry (2)
- Organic Chemistry (2)
- Other Chemicals and Drugs (2)
- Amino Acids, Peptides, and Proteins (1)
- Bacteriology (1)
- Behavioral Neurobiology (1)
- Biochemical Phenomena, Metabolism, and Nutrition (1)
- Biotechnology (1)
- Carbohydrates (1)
- Cardiovascular Diseases (1)
- Dietetics and Clinical Nutrition (1)
- Diseases (1)
- Laboratory and Basic Science Research (1)
- Medical Nutrition (1)
- Microbiology (1)
- Neuroscience and Neurobiology (1)
- Nucleic Acids, Nucleotides, and Nucleosides (1)
- Pharmaceutical Preparations (1)
- Pharmacy and Pharmaceutical Sciences (1)
- Public Health (1)
- Small or Companion Animal Medicine (1)
- Keyword
-
- Diabetes (2)
- Fucoxanthin (2)
- Health (2)
- Inflammation (2)
- Lipids (2)
-
- Obesity (2)
- ADHD (1)
- Amphiphile (1)
- Amphiphiles (1)
- Analogs (1)
- Antibacterial (1)
- Antisense Oligonucleotides (1)
- Bolaamphiphiles (1)
- CMC (1)
- Canine (1)
- Carbohydrate (1)
- Clinical (1)
- Conductivity (1)
- Critical micelle concentration (1)
- Cyclic Monomers (1)
- Cycling (1)
- Cyclization (1)
- DNA/RNA (1)
- Difluorobenzene (1)
- Difluorocarbene (1)
- Dry eye (1)
- Ergogenic-aids (1)
- Gastrointestinal (1)
- Honors students (1)
- Immunity (1)
Articles 1 - 10 of 10
Full-Text Articles in Chemicals and Drugs
Fucoxanthin: A Review Of Potential Benefits Relative To Human Health, Michael R. White
Fucoxanthin: A Review Of Potential Benefits Relative To Human Health, Michael R. White
Masters Theses, 2020-current
Fucoxanthin is a carotenoid sourced and extracted mainly from dark orange and brown seaweeds found in the pacific ocean, such as the wakame algae. The allenic bonds and unique oxygen groups give fucoxanthin its unique structure and are thought to be part of the reason fucoxanthin has unique physiological functions. Fucoxanthin has potentially numerous effects on the physiology of human health, ranging from skin health to metabolic health, which have been demonstrated in animal model research. The goal of this review is to examine current literature to discuss fucoxanthin’s potential application as a nutraceutical, treatment for obesity, type 2 diabetes, …
Fucoxanthin: A Review Of Potential Benefits Relative To Human Health, Michael R. White
Fucoxanthin: A Review Of Potential Benefits Relative To Human Health, Michael R. White
Masters Theses, 2020-current
Fucoxanthin is a carotenoid sourced and extracted mainly from dark orange and brown seaweeds found in the pacific ocean, such as the wakame algae. The allenic bonds and unique oxygen groups give fucoxanthin its unique structure and are thought to be part of the reason fucoxanthin has unique physiological functions. Fucoxanthin has potentially numerous effects on the physiology of human health, ranging from skin health to metabolic health, which have been demonstrated in animal model research. The goal of this review is to examine current literature to discuss fucoxanthin’s potential application as a nutraceutical, treatment for obesity, type 2 diabetes, …
Overcoming Degradation: A Novel Synthetic Strategy For Antisense Oligonucleotide Analogs, Annie Lin
Overcoming Degradation: A Novel Synthetic Strategy For Antisense Oligonucleotide Analogs, Annie Lin
Senior Honors Projects, 2010-2019
Antisense oligonucleotides (ASO) are single-stranded deoxyribonucleic acids that bind to mRNA to inhibit the synthesis of proteins that have been associated with the central mechanisms of disease development. Due to their gene silencing capabilities, the potential for ASOs as therapeutic agents is wide, but many toxicological challenges such as poor membrane permeability, low solubility, and rapid degradation by exonucleases must be overcome before ASO medications can be reliably utilized. In order to negate these challenges, the natural sugar- phosphate backbone of ASO’s, which is responsible for its rapid degradation, will be replaced by one that is hydrolytically stable. To do …
Investigating The Effect Of Sodium Benzoate On Immune Cells And Microbial Populations In The Small Intestine Of Murine Species., Shelby Pedigo
Investigating The Effect Of Sodium Benzoate On Immune Cells And Microbial Populations In The Small Intestine Of Murine Species., Shelby Pedigo
Senior Honors Projects, 2010-2019
Dietary ingredients can influence the mucosal surface morphology and mucosal immunity of the gastrointestinal tract. Additional health concerns and behavioral changes have been attributed to the consumption of foods containing preservatives and additives. Sodium benzoate (SB) is a commonly used bacteriostatic in food and beverages. This study investigates the effects of SB on the gut bacteria and mucosal health in the gastrointestinal tract of laboratory mice. The extent of lymphocytic infiltration in intestinal villi and granular density of Paneth cells in the ileum were used as evaluators of mucosal immunity. Adult C57BL/6 mice were randomly assigned to two …
Mouth Exposure To Carbohydrate Prior To Exercise Possibly Impairs The Efficacy Of Carbohydrate Mouth Rinsing During Exercise, Kevin Decker
Mouth Exposure To Carbohydrate Prior To Exercise Possibly Impairs The Efficacy Of Carbohydrate Mouth Rinsing During Exercise, Kevin Decker
Masters Theses, 2010-2019
Decker K. P., M. J. Saunders, N. D. Luden, C. J. Womack, and N. J. Hladick. Mouth Exposure to Carbohydrate Prior to Exercise Possibly Impairs the Efficacy of Carbohydrate Mouth Rinsing during Exercise. Purpose: Carbohydrate mouth-rinsing (CHO-MR) during intense endurance exercise has been associated with improved cycling performance, due to neurological influences. However, prior studies have reported the efficacy of CHO-MR is attenuated following a pre-exercise meal. To determine if this outcome is related to desensitization of CHO receptors (rather than metabolic effects following digestion), this study will investigate whether CHO-MR prior to exercise influences cycling performance when CHO-MR …
Clinical Study Of Canine Tear Lacritin As A Treatment For Dry Eye, Katherine E. Kelly
Clinical Study Of Canine Tear Lacritin As A Treatment For Dry Eye, Katherine E. Kelly
Senior Honors Projects, 2010-2019
Keratoconjunctivitis sicca (KCS), the deficiency of tears also known as dry eye, is a prevalent disease that affects both humans and canines. The current treatment for dye eye, cyclosporine (Restatis®), only provides temporary relief, is often associated with discomfort and is inconsistently effective. Lacritin is a naturally occurring tear glycoprotein secreted from the human and canine lacrimal glands. It has been shown that lacritin stimulates basal tearing in rabbits when applied topically. This study characterized the amount and form of lacritin found in the tears of dogs with healthy and dry eyes—information which may be applied to the development of …
The Synthesis Of 1,3-Difluoro-2-Methyl-4-Phenylbenzene From A One-Pot Reaction Of Difluorocarbene And 1-Phenyl-2-Methylcyclobutene, Ruth Felicitas Menger
The Synthesis Of 1,3-Difluoro-2-Methyl-4-Phenylbenzene From A One-Pot Reaction Of Difluorocarbene And 1-Phenyl-2-Methylcyclobutene, Ruth Felicitas Menger
Senior Honors Projects, 2010-2019
Previous studies show that 1,2-disubstituted cyclobutenes can be used in reaction with difluorocarbene to produce 1,3-difluorobenzenes. A pathway to the synthesis of these types of compounds is of interest due to their presence in fluoroquinolone antibacterials, resins, and insecticides. The synthesis is unique because the fluorine atoms from the difluorocarbene are not adjacent to each other when the ring expands to a benzene ring. This study focuses on the reaction of difluorocarbene with 1-phenyl-2-methylcyclobutene, which was synthesized in one-pot in 4 steps starting from 1-phenyl-1-propyne and zirconocene dichloride.
The Synthesis And Study Of The Biological And Colloidal Properties Of Bolaamphiphiles, Louis M. Damiano
The Synthesis And Study Of The Biological And Colloidal Properties Of Bolaamphiphiles, Louis M. Damiano
Senior Honors Projects, 2010-2019
Over the past decade, antibiotic resistant bacteria have caused infections in patients throughout the world.[1] The rise in antibiotic resistance is primarily due to the misuse and overuse of antibiotics. [1] To counter the increase in antibiotic resistance, infection control mechanisms have been aggressively researched in recent years. In particular, drug delivery has become a focal point to fight antibiotic resistant infections.[2] Amphiphiles have a wide range of applications in the clinical setting, including the ability to inhibit bacterial transference because of their bactericidal activity. [3] Bolaamphiphiles are a subclass of amphiphiles that possess two or more hydrophilic …
The Nonmedical Use Of Prescription Stimulants Among Students With High Academic Standing, Megan L. Dwyer
The Nonmedical Use Of Prescription Stimulants Among Students With High Academic Standing, Megan L. Dwyer
Senior Honors Projects, 2010-2019
College students report one of the highest rates of the nonmedical use of prescription stimulants (NPS). Research has shown that use is more common among students who have high levels of perceived stress, such as honors students. The purpose of this study was to determine whether honors students reported higher rates of NPS than their non-honors peers with high academic standing. It was hypothesized that honors students would report higher rates of use. The instrument used in this study was an email survey that was administered electronically through the online Qualtrics Survey system. The survey request was sent to 3,530 …
Colloidal And Biological Properties Of Triscationic Amphiphiles With One Or Two Tails, John N. Marafino
Colloidal And Biological Properties Of Triscationic Amphiphiles With One Or Two Tails, John N. Marafino
Masters Theses, 2010-2019
The decline in the development of novel antimicrobials, combined with the misusage and over prescription of antibiotics, has contributed to the increasing prevalence of antimicrobial-resistant infections. Thus development of effective novel disinfectants could reduce the transmission of pathogens and decrease the risk of infection by antibiotic resistant organisms. The antimicrobial activity of amphiphiles, compounds with hydrophobic and hydrophilic regions, was first reported in 1935, and has influenced the synthesis of amphiphiles with variations in structure. In this study, three series of amphiphiles were synthesized by two subsequent Menshutkin reactions. Each amphiphile contains one or two hydrocarbon tails ranging from 8 …