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Full-Text Articles in Chemicals and Drugs
Identification Of Plasma Lipid Biomarkers In Alzheimer's Disease, Rhona Creegan
Identification Of Plasma Lipid Biomarkers In Alzheimer's Disease, Rhona Creegan
Theses: Doctorates and Masters
Alzheimer’s disease (AD), the commonest form of dementia, is a chronic, progressive neurodegenerative disease which manifests clinically as a slow global decline in cognitive function, including deterioration of memory, reasoning, abstraction, language and emotional stability, culminating in a patient with end-stage disease, totally dependent on custodial care. With an ageing population, there is predicted to be a marked increase in the number of people diagnosed with AD in the coming decades, making this a significant challenge to socio-economic policy and aged care. Currently there is no cure for AD and while current therapies may temporarily ameliorate symptoms, death usually occurs …
Finite Element Analysis Of Stress Distribution Within Metal-On-Metal Joint Replacements, Yujing Liu
Finite Element Analysis Of Stress Distribution Within Metal-On-Metal Joint Replacements, Yujing Liu
Theses: Doctorates and Masters
Demand for joint replacements is rising in Australia, driven by a sharp increase in the number of joint problems associated with population aging and obesity. In artificial joints, delamination or failure within the coatings occurs when the stress reaches a critical level, resulting in large wear debris particles appearing on the contact surface between the head and the cup. The process has been described as due to a stress-corrosion-cracking mechanism. Under the same loading, stress increases when the contact area decreases, which happens in the vicinity of wear debris. As such, once wear debris is generated, a catastrophic process could …