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Host Microbiome Regulation Of Hyperthermia Mediated By 3,4-Methylenedioxymethamphetamine (Mdma, Molly), Emily Ridge
Host Microbiome Regulation Of Hyperthermia Mediated By 3,4-Methylenedioxymethamphetamine (Mdma, Molly), Emily Ridge
Honors Projects
Hyperthermia is one of the most acute and life-threatening consequences of 3,4-methylenedioxymethamphetamine (MDMA) use. The hyperthermia induced by MDMA involves a complex interaction between heat generation and loss of heat dissipation. Recent studies have demonstrated a role for gut microbiome in the regulation of body weight and temperature. Here, we investigated the potential role of the gut microbiome in MDMA-mediated hyperthermia. For fourteen days prior to treatment with MDMA (20 mg/kg, sc) male, Sprague-Dawley rats were provided regular drinking water or drinking water laced with the non-absorbable antibiotics, bacitracin (0.5 mg/mL), neomycin (2mg/mL), and vancomycin (0.2mg/mL). Antibiotic (ABX) treatment reduced …