Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 2 of 2
Full-Text Articles in Chemicals and Drugs
Antibiotic Resistance In Escherichia Coli Iron Transport Mutants, Madeline Brandt
Antibiotic Resistance In Escherichia Coli Iron Transport Mutants, Madeline Brandt
Honors Projects
Studies previously completed on Escherichia coli mutants suggested the possibility of iron uptake as an influence on the antibiotic resistance seen in different strains. The research focused on the TonB energy transduction system and its contributions to efflux-mediated antibiotic resistance. To test the hypothesis that iron uptake has an influence on antibiotic resistance in Escherichia coli, the sensitivity to a variety of antibiotics was evaluated in strains of E. coli lacking genes that relate to the uptake of iron or the efflux system that is necessary for the uptake of iron. To test the efflux systems TolC and TonB …
Host Microbiome Regulation Of Hyperthermia Mediated By 3,4-Methylenedioxymethamphetamine (Mdma, Molly), Emily Ridge
Host Microbiome Regulation Of Hyperthermia Mediated By 3,4-Methylenedioxymethamphetamine (Mdma, Molly), Emily Ridge
Honors Projects
Hyperthermia is one of the most acute and life-threatening consequences of 3,4-methylenedioxymethamphetamine (MDMA) use. The hyperthermia induced by MDMA involves a complex interaction between heat generation and loss of heat dissipation. Recent studies have demonstrated a role for gut microbiome in the regulation of body weight and temperature. Here, we investigated the potential role of the gut microbiome in MDMA-mediated hyperthermia. For fourteen days prior to treatment with MDMA (20 mg/kg, sc) male, Sprague-Dawley rats were provided regular drinking water or drinking water laced with the non-absorbable antibiotics, bacitracin (0.5 mg/mL), neomycin (2mg/mL), and vancomycin (0.2mg/mL). Antibiotic (ABX) treatment reduced …