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Full-Text Articles in Chemicals and Drugs
Structure-Based Drug Design Of Novel Therapeutics Targeting Oncostatin M, Kelsey Skluzacek
Structure-Based Drug Design Of Novel Therapeutics Targeting Oncostatin M, Kelsey Skluzacek
Boise State University Theses and Dissertations
At 30% of all new diagnoses, the most prevalent malignancy for women is breast cancer, which in the United States will result in an estimated 266,000 new cases this year alone. Of the patients diagnosed with breast cancer, approximately 10-15% will develop distant metastases within three years of the initial detection of a primary tumor. For comparison, the five-year survival rate for localized breast cancer is 99%, whereas, the survival rate for metastatic breast cancer drops drastically to only 27%. The significant difference in survival rates is indicative of a need for a novel treatment strategy for metastatic breast cancer. …
Potent And Potentially Non-Cardiotoxic Anthracyclines: Their Synthesis, Biological Evaluation, And Comparison Of Hydrozone-Mediated Reductions, Jerrett Holdaway
Potent And Potentially Non-Cardiotoxic Anthracyclines: Their Synthesis, Biological Evaluation, And Comparison Of Hydrozone-Mediated Reductions, Jerrett Holdaway
Boise State University Theses and Dissertations
After nearly half a century since medical approval, the anthracycline doxorubicin (DOX) remains one of the most potent and clinically useful anticancer agents. In spite of its long history, however, the cytotoxic mechanisms of DOX have been debated and remain controversial. Several well-supported mechanisms will be discussed, such as the potential to intercalate DNA and induce apoptosis through topoisomerase poisoning, free radical formation, and DNA cross-linking. While DOX has substantial medical importance, it is plagued by a life-threatening dose-dependent cardiotoxic side effect associated with several structural groups. A number of modifications to DOX have been accomplished to attempt to remove …
Total Synthesis Of 6,7-Dimethyl-N-Methyl Aziridinomitosene, Thaaer N. Muhammed
Total Synthesis Of 6,7-Dimethyl-N-Methyl Aziridinomitosene, Thaaer N. Muhammed
Boise State University Theses and Dissertations
Mitomycin C (MC) is a naturally occurring antitumor agent isolated from a soil bacterium. MC is effective against solid hypoxic tumors that respond poorly to radiotherapy, such as colorectal, gastric, and lung tumors. Also, it has a role in the treatment of bladder, head and neck, and non-small cell lung cancers in combination with other chemotherapeutic.
MC and other members of the mitomycin family of antitumor agents fight cancer by forming DNA interstrand crosslinks (ICLs), which leads to apoptosis. In order to form ICLs, MC requires a reductive activation step that produces reactive oxygen species. This activation step is proposed …