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Full-Text Articles in Chemicals and Drugs
Driving Under The Influence Of Cannabis: Impact Of Combining Toxicology Testing With Field Sobriety Tests, Robert L. Fitzgerald, Anya Umlauf, Jacqueline A. Hubbard, Melissa A. Hoffman, Philip M. Sobolesky, Shannon E. Ellis, David J. Grelotti, Raymond T. Suhandynata, Marilyn A. Huestis, Igor Grant, Thomas D. Marcotte
Driving Under The Influence Of Cannabis: Impact Of Combining Toxicology Testing With Field Sobriety Tests, Robert L. Fitzgerald, Anya Umlauf, Jacqueline A. Hubbard, Melissa A. Hoffman, Philip M. Sobolesky, Shannon E. Ellis, David J. Grelotti, Raymond T. Suhandynata, Marilyn A. Huestis, Igor Grant, Thomas D. Marcotte
Institute of Emerging Health Professions Faculty Papers
BACKGROUND: Cannabis is increasingly used both medically and recreationally. With widespread use, there is growing concern about how to identify cannabis-impaired drivers.
METHODS: A placebo-controlled randomized double-blinded protocol was conducted to study the effects of cannabis on driving performance. One hundred ninety-one participants were randomized to smoke ad libitum a cannabis cigarette containing placebo or delta-9-tetrahydrocannabinol (THC) (5.9% or 13.4%). Blood, oral fluid (OF), and breath samples were collected along with longitudinal driving performance on a simulator (standard deviation of lateral position [SDLP] and car following [coherence]) over a 5-hour period. Law enforcement officers performed field sobriety tests (FSTs) to …
Effects Of Oral, Smoked, And Vaporized Cannabis On Endocrine Pathways Related To Appetite And Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Human Laboratory Study., Mehdi Farokhnia, Gray R Mcdiarmid, Matthew N Newmeyer, Vikas Munjal, Osama A Abulseoud, Marilyn A Huestis, Lorenzo Leggio
Effects Of Oral, Smoked, And Vaporized Cannabis On Endocrine Pathways Related To Appetite And Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Human Laboratory Study., Mehdi Farokhnia, Gray R Mcdiarmid, Matthew N Newmeyer, Vikas Munjal, Osama A Abulseoud, Marilyn A Huestis, Lorenzo Leggio
Institute of Emerging Health Professions Faculty Papers
As perspectives on cannabis continue to shift, understanding the physiological and behavioral effects of cannabis use is of paramount importance. Previous data suggest that cannabis use influences food intake, appetite, and metabolism, yet human research in this regard remains scant. The present study investigated the effects of cannabis administration, via different routes, on peripheral concentrations of appetitive and metabolic hormones in a sample of cannabis users. This was a randomized, crossover, double-blind, placebo-controlled study. Twenty participants underwent four experimental sessions during which oral cannabis, smoked cannabis, vaporized cannabis, or placebo was administered. Active compounds contained 6.9 ± 0.95% (~50.6 mg) …