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Gene Expression In The Mouse Placenta: Developmental And Stress Responses, Ciprian P. Gheorghe
Gene Expression In The Mouse Placenta: Developmental And Stress Responses, Ciprian P. Gheorghe
Loma Linda University Electronic Theses, Dissertations & Projects
Successful placental development is crucial for optimal growth, maturation, and survival of the embryo/fetus. Placental failure and placental pathology contributes to both morbidity and mortality of the fetus. We sought to understand normal placental development and also placental responses to stress using oligonucleotide microarray technology. To examine genetic aspects of normal placental development, we investigated gene expression patterns in the murine placenta at embryonic day 10.5 (E10.5), E12.5, E15.5, and E17.5. Hypoxia has been identified as a major stressor in placental and fetal development. In order to comprehend more completely hypoxic stress responses we sought to measure gene expression changes …
Factors That Influence The Blood Flow Response Of Skin To Electrical Stimulation, Abdul-Majeed Raja Al-Malty
Factors That Influence The Blood Flow Response Of Skin To Electrical Stimulation, Abdul-Majeed Raja Al-Malty
Loma Linda University Electronic Theses, Dissertations & Projects
Female reproductive hormones, aging, global heating and local heating are factors affecting skin blood flow (SBF), but their effect on electrical stimulation (ES) has never been examined until the present investigation. To investigate female reproductive hormones, nine women (age= 25.6±3.5 years) with a normal menstrual cycle (MC) underwent ES in thermoneutral (25°±0.5°C) and warm environments (35°±0.5°C). To investigate aging, ES was applied on active young (n=15, age=32.1±8.3 years) and old (n=8, 64.5±6.2 years) groups in thermoneutral and warm environments. To investigate the effect of global and local heating, groups of 15 and 18 subjects (age= 18-40 years) experienced ES under …