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Articles 1 - 3 of 3
Full-Text Articles in Chemicals and Drugs
Synthesis, Including Microwave Promotion, Of Selected Cyclopropyl Derivatives As Stereochemically Rigid Probes Of Certain Pharmalogical Receptors, Grace Hohn
Honors Program Projects
Pharmacologic intervention with stereochemical probes allows for the treatment of medical conditions by affecting receptors in the body and causing receptors to respond to the presence of the probe. Novel cyclopropyl derivatives were synthesized could serve as a stereochemically rigid probes of certain pharmacological receptors and could have potential use as a drug. A probe is a molecule or ligand that can bind to and interact with a receptor in the human body. This interaction triggers a desirable response by increasing or decreasing the presence of a compound (e.g. dopamine for depression) in order to repair a chemical imbalance in …
Partial Preparation Of 1-Anilino-8-(Mercaptoamino)-1,8-Octadione As A Potential Therapeutic Agent For The Treatment Of Huntington’S Disease And Selected Cancers, Macy Sprunger
Honors Program Projects
We are proposing 1-anilino-8-(mercaptoamino)-1,8-octadione as a compound of potential pharmaceutical value. The addition of carbon disulfide to sodium trimethylsilanolate to yield a xanthate product has been analyzed and refined to a 70% yield. Several methods of aminating the xanthate product to yield a sulfenamide have been attempted and analyzed. Multiple attempts have been made to benzoylate the sulfenamide product with little success, with many concerns stemming from the unsuccessful amination reactions.
Synthesis And Polarographic Analysis Of A2e, Elise Rivett
Synthesis And Polarographic Analysis Of A2e, Elise Rivett
Honors Program Projects
As humans age, fluorescent retinoid pigments accumulate in the retinal pigment epithelial (RPE) cells responsible for photoreceptor support. These fluorophores are of interest because they seem to contribute to diseases of the retina, particularly age-related macular degeneration, which is a leading cause of blindness in older adults in the United States and currently has no cure. One well-characterized fluorophore, A2E, can be oxidized by visible light and then generate harmful oxidative species capable of inducing programmed cell death in RPE cells. Further characterization of the redox behavior of A2E could ultimately aid the development of macular degeneration treatments designed to …