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Full-Text Articles in Chemicals and Drugs
Various Synthetic Pathways Towards Efavirenz And Its Analogs; The Replacement Of The Side Chain, Elizabeth S. Bautista
Various Synthetic Pathways Towards Efavirenz And Its Analogs; The Replacement Of The Side Chain, Elizabeth S. Bautista
Selected Honors Theses
Cyclopropyl acetylene (CA) is a key intermediate in the synthesis of the human immunodeficiency virus (HIV) reverse transcriptase inhibitor, Efavirenz (EFV), an antiviral drug used to treat HIV. CA is an expensive raw material, difficult to obtain, and employed in the preparation of medications to combat acquired immunodeficiency syndrome (AIDS). It was found that the structure could be synthesized by the utilization of PCl5; however, this resulted in unwanted ring opening products. To address this issue, a one pot synthesis was developed using Ph3PCl2 as a mild chlorinating agent. In addition, a new analog has been proposed substituting the cyclopropyl …
Crohn’S Disease And Omega 3: Can It Decrease Crp? A Literature Review, Ariana L. Vyvjala
Crohn’S Disease And Omega 3: Can It Decrease Crp? A Literature Review, Ariana L. Vyvjala
Bachelors of Science in Nursing
The Crohn’s and Colitis foundation of America estimates that 70,000 Americans are diagnosed with inflammatory bowel disease (IBD) each year (2021). Crohn's disease is an inflammatory bowel disease characterized by periods of remission and exacerbation triggered by an increase in stress (Mackner et al., 2020). Patients can experience debilitating abdominal pain, diarrhea, fatigue, blood in the stool, and reduced appetite during an exacerbation period, all of which can lead to life-threatening complications (Mayo Clinic, 2020). In most cases, patients are diagnosed in their late teens or early adulthood years, and are prescribed anti-inflammatory drugs (Mayo Clinic, 2020). As there is …