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Full-Text Articles in Chemicals and Drugs
Caepidr: A Computational Approach To Efficient Peptide Influenced Drug Repurposing, Thomas Francis Long
Caepidr: A Computational Approach To Efficient Peptide Influenced Drug Repurposing, Thomas Francis Long
Boise State University Theses and Dissertations
Since the discovery of the molecular basis of disease, numerous studies have reported a correlation between the activity of specific protein receptors the progression of disease. As a result, drug development has become dependent on the study of protein receptor activities. The relative inexpense of computing hardware has made computational methods an important supplementary tool for receptor modeling. This work details an open source software tool that is capable of both efficiently screening large peptide mutant libraries and enabling 3D conformer-based searches over local molecular databases.
A Computational Approach to Efficient Peptide Influenced Drug Repurposing (CAEPIDR) has been developed to …
Design, Synthesis And Biological Evaluation Of Novel Compounds With Cns-Activity Targeting Cannabinoid And Biogenic Amine Receptors, Alexander M. Sherwood
Design, Synthesis And Biological Evaluation Of Novel Compounds With Cns-Activity Targeting Cannabinoid And Biogenic Amine Receptors, Alexander M. Sherwood
University of New Orleans Theses and Dissertations
This work seeks to contribute to the discipline of neuropharmacology by way of structure activity relationship from the standpoint of an organic chemist. More specifically, we sought to develop robust synthetic methodology able to efficiently produce an array of compounds for the purpose of systematic evaluation of their interaction with specific sights within the central nervous system (CNS) in order to better understand the mind and to develop drugs that may have beneficial effects on neurological function.
The focus of these studies has been toward the development of novel molecules, using a structure-activity relationship approach, that exhibit binding affinity at …
Syntheses Of Precursors To Fluorine-18 Labeled Pet Imaging Agents, Lindsay B. Boling
Syntheses Of Precursors To Fluorine-18 Labeled Pet Imaging Agents, Lindsay B. Boling
Chancellor’s Honors Program Projects
No abstract provided.
Quantification Of Factors Governing Drug Release Kinetics From Nanoparticles: A Combined Experimental And Mechanistic Modeling Approach, Kyle Daniel Fugit
Quantification Of Factors Governing Drug Release Kinetics From Nanoparticles: A Combined Experimental And Mechanistic Modeling Approach, Kyle Daniel Fugit
Theses and Dissertations--Pharmacy
Advancements in nanoparticle drug delivery of anticancer agents require mathematical models capable of predicting in vivo formulation performance from in vitro characterization studies. Such models must identify and incorporate the physicochemical properties of the therapeutic agent and nanoparticle driving in vivo drug release. This work identifies these factors for two nanoparticle formulations of anticancer agents using an approach which develops mechanistic mathematical models in conjunction with experimental studies.
A non-sink ultrafiltration method was developed to monitor liposomal release kinetics of the anticancer agent topotecan. Mathematical modeling allowed simultaneous determination of drug permeability and interfacial binding to the bilayer from release …