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Full-Text Articles in Chemicals and Drugs
Total Synthesis Of 6,7-Dimethyl-N-Methyl Aziridinomitosene, Thaaer N. Muhammed
Total Synthesis Of 6,7-Dimethyl-N-Methyl Aziridinomitosene, Thaaer N. Muhammed
Boise State University Theses and Dissertations
Mitomycin C (MC) is a naturally occurring antitumor agent isolated from a soil bacterium. MC is effective against solid hypoxic tumors that respond poorly to radiotherapy, such as colorectal, gastric, and lung tumors. Also, it has a role in the treatment of bladder, head and neck, and non-small cell lung cancers in combination with other chemotherapeutic.
MC and other members of the mitomycin family of antitumor agents fight cancer by forming DNA interstrand crosslinks (ICLs), which leads to apoptosis. In order to form ICLs, MC requires a reductive activation step that produces reactive oxygen species. This activation step is proposed …
Caepidr: A Computational Approach To Efficient Peptide Influenced Drug Repurposing, Thomas Francis Long
Caepidr: A Computational Approach To Efficient Peptide Influenced Drug Repurposing, Thomas Francis Long
Boise State University Theses and Dissertations
Since the discovery of the molecular basis of disease, numerous studies have reported a correlation between the activity of specific protein receptors the progression of disease. As a result, drug development has become dependent on the study of protein receptor activities. The relative inexpense of computing hardware has made computational methods an important supplementary tool for receptor modeling. This work details an open source software tool that is capable of both efficiently screening large peptide mutant libraries and enabling 3D conformer-based searches over local molecular databases.
A Computational Approach to Efficient Peptide Influenced Drug Repurposing (CAEPIDR) has been developed to …