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In-Line Monitoring Of Sitagliptin Dissolution Profile From Tablets Utilizing An Eco-Friendly Potentiometric Sensor, Shereen Mowaka, Manar M. Elhassan, Amr M. Mahmoud, Maha A. Hegazy
In-Line Monitoring Of Sitagliptin Dissolution Profile From Tablets Utilizing An Eco-Friendly Potentiometric Sensor, Shereen Mowaka, Manar M. Elhassan, Amr M. Mahmoud, Maha A. Hegazy
Pharmacy
Sitagliptin, an oral antidiabetic drug, is an effective medication for lowering blood glucose level either as monotherapy or in combination with other antidiabetic drugs. This work aims for the fabrication of a potentiometric sensor for sitagliptin detection. The sensor was designed by doping the polyvinyl chloride polymeric ion-selective membrane with calix[4]arene as an ionophore which highly improved the linearity range (1 × 10−6—1 × 10−2 M), sensitivity, selectivity and limit of detection (6.3 × 10−7 M) compared to ionophore-free membrane. The method was then validated according to the International Council for Harmonization (ICH) guidelines. The sensor was successfully employed to …
Electrochemical Determination Of Ipragliflozin In Pure Form And In Spiked Human Plasma On A Glassy Carbon Electrode, Shereen Mowaka, Manar M. Elhassan, Amr M. Mahmoud, Maha A. Hegazy
Electrochemical Determination Of Ipragliflozin In Pure Form And In Spiked Human Plasma On A Glassy Carbon Electrode, Shereen Mowaka, Manar M. Elhassan, Amr M. Mahmoud, Maha A. Hegazy
Pharmacy
Ipragliflozin, a highly potent and selective sodium glucose cotransporter II inhibitor, is an effective blood glucose lowering drug in patients with type 2 diabetes mellitus by promoting urinary glucose excretion. The present work represents the first electrochemical determination of ipragliflozin that depends on the oxidation of sulfur atom present in its structure. Cyclic wave and differential pulse voltammetry were applied by scanning potential over range of 0 to 2.8 V vs the reference electrode Ag/Ag+ in non-aqueous medium. The method was developed and validated in accordance with the guidelines of the International Council for Harmonisation (ICH). With a detection limit …