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Full-Text Articles in Chemicals and Drugs
Development Of Lc-Ms For The Identification And Characterization Of Non-Adjacent Dna Photoproduct Formation In G-Quadruplex Forming Sequences, Claudia Posadas
Development Of Lc-Ms For The Identification And Characterization Of Non-Adjacent Dna Photoproduct Formation In G-Quadruplex Forming Sequences, Claudia Posadas
Arts & Sciences Electronic Theses and Dissertations
Ultraviolet light is well known to induce cyclobutane pyrimidine dimers (CPD) and pyrimidine (6–4) pyrimidone photoproducts in duplex DNA, which interfere with DNA replication and transcription. Recently, a new class of DNA photoproducts known as anti cyclobutanepyrimidine dimers have been discovered, which form in G-quadruplex forming sequences in solution. G-quadruplex structures have been proposed to form in human DNA telomeres and certain promoters in vivo but evidence for their existence has been lacking. Since anti-cyclobutante pyrimidine dimers have been shown to form in G-quadruplex forming sequences, their formation in irradiated human cells could be used to confirm the existence …
Resveratrol Induced Apoptosis In A Human Adenosquamous Carcinoma Cell Line (Cal-27 Cells), Saquib A. Siddiqi
Resveratrol Induced Apoptosis In A Human Adenosquamous Carcinoma Cell Line (Cal-27 Cells), Saquib A. Siddiqi
PCOM Biomedical Studies Student Scholarship
Radiotherapy and surgery are the two principal modalities in the treatment of head and neck cancers, and both therapies can result in severe adverse effects and ultimately lower the quality of life. It is of paramount importance to develop reagents that target the cancer cell specifically without affecting the normal non-cancer cells. Using the tongue cancer cell line Cal 27 as a model system, we dissected the molecular mechanism of the resveratrol-induced cancer cell apoptosis. After demonstrating that resveratrol induces the cancer cell apoptosis in a dose- and time-dependent manner, a systemic apoptosis protein array was conducted to identify the …