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The Effect Of Cannabinoids On Triple Negative Breast Cancer Cells, Haley Dahl
The Effect Of Cannabinoids On Triple Negative Breast Cancer Cells, Haley Dahl
Honors Theses
Triple Negative Breast Cancer (TNBC) is a difficult type of cancer to treat because it is negative for progesterone, estrogen, and HER-2 receptors. Because TNBC is negative for these three receptors, it does not respond to normal hormonal therapies. The purpose of my experiment is to see if different cannabinoids, compounds from the cannabis plants, could be used as alternative treatment options. These experiments employed three different cannabinoids: ajulemic acid, cannabidiol, and hemp oil. Cell viability was measured after 72 hours of treatment using a MTT assay. The results showed that the three cannabinoids could be used to effectively destroy …
Thrilling Monotony: A Summer Of Alzheimer's Research, Baronger Dowell Bieger
Thrilling Monotony: A Summer Of Alzheimer's Research, Baronger Dowell Bieger
Honors Theses
The primary genetic risk determinant for late-onset Alzheimer's disease is the apolipoprotein E gene (APOE). Variations in this gene produce three different isoforms of the apolipoprotein E protein (ApoE): ApoE2, ApoE3, and ApoE4. ApoE# is the most common isoform, so rates of LOAD among other genotypes are indexed to this variant. ApoE2 is rather rare, but its carriers are less likely to get LOAD; when they do, they get it later. The second most common variant is ApoE4, and its carriers are significantly more likely to get LOAD. They also tend to succumb earlier. Once developed, LOAD is characterized by …
The Effects Of Ajulemic Acid On The Metatastic Potential Of Ewing's Sarcoma, Nolan J. West
The Effects Of Ajulemic Acid On The Metatastic Potential Of Ewing's Sarcoma, Nolan J. West
Honors Theses
Ewing's Sarcoma belongs in the Ewing's Sarcoma Family of Tumors (EFST) which represents approximately 2% of all cancers found in children and young adults. These tumors are generally treated by chemotherapy along with either surgery or radiation therapy which can themselves have debilitating effects on the patients. Dr. Lori Hensley's research has shown that ajulemic acid (AJA), a synthetic cannabinoid compound, exhibits extraordinary anti-tumor effects. In addition, AJA has not expressed any psychotropic side effects typically seen with other cannabinoids. Furthermore, ajulemic acid has been shown to eliminate the tumors by apoptosis, the preferred method of cell death. The purpose …