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Full-Text Articles in Chemicals and Drugs
Use Of A Zebrafish Model To Identify Anticonvulsant Properties Of Cannabinoid And Terpenoid Extracts And Mixtures, Courtney Murr
Use Of A Zebrafish Model To Identify Anticonvulsant Properties Of Cannabinoid And Terpenoid Extracts And Mixtures, Courtney Murr
LSU Master's Theses
Epilepsy is a complex group of neurological disorders affecting approximately 65 million people worldwide. Animal models reveal the activation of cannabinoid receptor 1 and cannabinoid receptor 2 reduces the severity of seizures associated with epilepsy. Trials of phytocannabinoids in mammals demonstrate their efficacy of reducing the severity of epileptic seizures. Numerous terpenoid compounds are present in Cannabis plants but most have yet to be clinically investigated. The goal of this research was to use zebrafish (Danio rerio) to identify the potential anticonvulsive properties of phytocannabinoid and terpenoid compounds. During acute cannabinoid exposures, 7-days-post-fertilization (7 dpf) zebrafish larvae were …
The Effects Watermelon Juice On Post Prandial Vascular Endothelial Function And Blood Flow During Hyperglycemia, Cullen M. Vincellette
The Effects Watermelon Juice On Post Prandial Vascular Endothelial Function And Blood Flow During Hyperglycemia, Cullen M. Vincellette
LSU Master's Theses
Impaired endothelial function and microvascular dysfunction are frequently observed in individuals with cardiovascular risk factors such as obesity, insulin resistance, and type 2 diabetes. Reduced nitric oxide (NO) bioavailability is considered to be central to the development of these risk factors. NO can be generated via enzymatic reaction via NO synthase which requires the amino acid arginine. Evidence suggests that the amino acid citrulline is more effective at increasing circulating arginine levels than arginine supplementation alone. The purpose of this pilot study is to determine the potential for citrulline-rich watermelon juice (WMJ) to attenuate the reduction in postprandial endothelial function …