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Full-Text Articles in Cardiovascular System
Vascular Regulation Via Kir Channels And Na+ /K+-Atpase, Anne R. Crecelius, Frank A. Dinenno
Vascular Regulation Via Kir Channels And Na+ /K+-Atpase, Anne R. Crecelius, Frank A. Dinenno
Health and Sport Science Faculty Publications
Despite the longstanding knowledge that blood flow increases in proportion to metabolic activity of skeletal muscle, the underlying mechanisms that govern this response have only recently been identified.1 Given the role of endothelial cells in mediating exercise hyperemia,2 interest has been focused on endothelium-derived vasodilation occurring via the synthesis of nitric oxide (NO) and vasodilating prostaglandins (PGs; i.e. prostacyclin) or endothelium- derived hyperpolarization. A number of studies performed in humans have established a minimal-to-modest role for NO and PGs during mild- and moderate- intensity exercise. In animal preparations, prevention of hyperpolarization attenuates contraction-induced hyperemia; however, performing similar studies …
Intravascular Atp And The Regulation Of Blood Flow And Oxygen Delivery In Humans, Anne R. Crecelius, Brett S. Kirby, Frank A. Dinenno
Intravascular Atp And The Regulation Of Blood Flow And Oxygen Delivery In Humans, Anne R. Crecelius, Brett S. Kirby, Frank A. Dinenno
Health and Sport Science Faculty Publications
Regulation of vascular tone is a complex response that integrates multiple signals which allow for blood flow and oxygen supply to appropriately match oxygen demand. Here, we discuss the potential role of intravascular ATP as a primary factor in these responses and propose that deficient ATP release may contribute to impairments in vascular control exhibited in aged and diseased populations.