Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons^™

Effects Of Furosemide And Oleic Acid On Thyroxine Binding To Isolated Pairs Of Thyroxine Binding Serum Proteins, Deborah Hustead

Loma Linda University Electronic Theses, Dissertations & Projects

Dosage dependent binding inhibition and redistribution of thyroxine (T₄) between three pairs of thyroxine binding serum proteins, TBG-TTR, TBG-albumin and TTR-albumin, by furosemide (0.0 to 1.0 mol/L) and oleic acid (0.0 to 0.10 mol/L) were studied using equilibrium dialysis with purified binding proteins at concentrations 1/200 of levels in normal human sera, separated across the dialysis membrane and competing for T₄.

Furosemide (1.0 mol/L) reduced TBG bound T₄ in both the TBG-TTR system and TBG-albumin system (>90% decrease) and inhibited T₄ binding to TTR in the TTR-albumin system (68% decrease) and to albumin …

Review Of: Carl F. Cranor, Regulating Toxic Substances, Jon F. Merz, H. Christopher Frey

RISK: Health, Safety & Environment (1990-2002)

Review of: Carl F. Cranor, Regulating Toxic Substances (Oxford University Press 1993). Acknowledgments, appendices, bibliography, figures, foreword by The Honorable George E. Brown, Jr., index, notes, tables. LC 91-47046; ISBN 0-19- 507436-X. [272 pp. Cloth $45.00. 200 Madison Avenue, New York NY 10016.]

Cranor's Reply, Carl F. Cranor

RISK: Health, Safety & Environment (1990-2002)

Dr. Cranor's reply to Merz and Frey.