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Full-Text Articles in Analytical, Diagnostic and Therapeutic Techniques and Equipment
Functional Significance Of The Upregulation Of Adhesion Molecules On Irradiated Endothelial Cells, Balabhaskar Prabhakarpandian
Functional Significance Of The Upregulation Of Adhesion Molecules On Irradiated Endothelial Cells, Balabhaskar Prabhakarpandian
Theses and Dissertations (ETD)
Ionizing radiation is a major therapy for cancer. Damage to the endothelium and upregulation of inflammatory responses are major side effects of radiotherapy, but the mechanisms behind these processes are not clear. A key component of the inflammatory response is leukocytes adhesion to the endothelium in a multi-step process involving leukocyte tethering to the endothelium, followed by rolling, firm adhesion/spreading and extravasation. Adhesion molecules mediate this process, particularly, E-selectin and ICAM-1, which are inducible adhesion molecules. E-selectin is involved in the initial tethering and rolling steps of the adhesion cascade while ICAM-1 appears to be involved in the latter steps. …
Late Effects Of Ionizing Radiation On Normal Microvascular Networks, Vinh Nguyen
Late Effects Of Ionizing Radiation On Normal Microvascular Networks, Vinh Nguyen
Theses and Dissertations (ETD)
Therapeutic doses of ionizing radiation result in changes in the structure and function of microvascular networks in normal tissue. Previously, we reported on the early effects of ionizing radiation on microvascular networks at 3, 7, and 30 days post-irradiation [1-3]. Data from the early time points suggested that ionizing radiation significantly alters the structure and function of microvascular networks and interferes with the normal processes of vessel maturation. Here, we
present our findings on the late effects of ionizing radiation on normal tissue microvasculature at 60, 120, and 180 days post-irradiation. The cremaster muscle of Golden Syrian hamster was locally …