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Full-Text Articles in Analytical, Diagnostic and Therapeutic Techniques and Equipment
Creation Of An Injectable In Situ Gelling Native Extracellular Matrix For Nucleus Pulposus Tissue Engineering, Rebecca A. Wachs, Ella N. Hoogenboezem, Hammad I. Huda, Shangjing Xin, Stacy L. Porvasnik, Christine E. Schmidt
Creation Of An Injectable In Situ Gelling Native Extracellular Matrix For Nucleus Pulposus Tissue Engineering, Rebecca A. Wachs, Ella N. Hoogenboezem, Hammad I. Huda, Shangjing Xin, Stacy L. Porvasnik, Christine E. Schmidt
Biological Systems Engineering: Papers and Publications
Background Context: Disc degeneration is the leading cause of low back pain and is often characterized by a loss of disc height, resulting from cleavage of chondroitin sulfate proteoglycans (CSPGs) present in the nucleus pulposus. Intact CSPGs are critical to water retention and maintenance of the nucleus osmotic pressure. Decellularization of healthy nucleus pulposus tissue has the potential to serve as an ideal matrix for tissue engineering of the disc because of the presence of native disc proteins and CSPGs. Injectable in situ gelling matrices are the most viable therapeutic option to prevent damage to the anulus fibrosus and future …
Micro- And Nanoparticulates For Dna Vaccine Delivery, Eric Farris, Deborah M. Brown, Amanda Ramer-Tait, Angela K. Pannier
Micro- And Nanoparticulates For Dna Vaccine Delivery, Eric Farris, Deborah M. Brown, Amanda Ramer-Tait, Angela K. Pannier
Biological Systems Engineering: Papers and Publications
DNA vaccination has emerged as a promising alternative to traditional protein-based vaccines for the induction of protective immune responses. DNA vaccines offer several advantages over traditional vaccines, including increased stability, rapid and inexpensive production, and flexibility to produce vaccines for a wide variety of infectious diseases. However, the immunogenicity of DNA vaccines delivered as naked plasmid DNA is often weak due to degradation of the DNA by nucleases and inefficient delivery to immune cells. Therefore, biomaterial-based delivery systems based on micro- and nanoparticles that encapsulate plasmid DNA represent the most promising strategy for DNA vaccine delivery. Microparticulate delivery systems allow …