Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons^™

Coherent Scatter Computed Tomography For Core Composition Analysis Of Intact Kidney Stones - Prospective Clinical Study, Cristian Dihel

Electronic Thesis and Dissertation Repository

Urolithiasis is the presence of urinary calculi (urinary stones) at any level along the excretory system. Establishing accurate and complete mineral composition of the stones is one of the main factors in deciding the best steps for therapy and recurrence prevention.

Currently, infrared spectroscopy (IRS) and x-ray diffractometry (XRD) provide bulk composition results of urinary calculi in powdered form. Clinicians use the results to prescribe medical and dietary measures to restore the physiologic chemical balance of urine or rather alter it for the purpose of decreasing the crystallization rate of single or multiple minerals. As current methods have been shown …

Targeted Intracellular Therapeutic Delivery Using Liposomes Formulated With Multifunctional Fast Proteins, Rae L. Nesbitt

Electronic Thesis and Dissertation Repository

Prostate cancer is the most common malignancy in North American men and there is no treatment currently available which offers a clear survival advantage to patients with prostate cancer. We studied liposomes formulated with the fusion-associated small transmembrane (FAST) protein, p14. In this study, we hypothesized that therapeutics delivered in molecular targeted fusogenic liposomes will increase intracellular delivery and specificity for prostate cancer. We demonstrated that liposomes formulated with p14-bombesin significantly increased the delivery of fluorescein isothiocyanate (FITC) into human prostate cancer (PC-3) cells compared to either standard liposomes or non-targeted fusogenic liposomes. Delivery of FITC to benign prostate hyperplasia …