Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons^™

A Multi-Channel 3d-Printed Bioreactor For Evaluation Of Growth And Production In The Microalga Dunaliella Sp, Cristian A. Cox

Electronic Theses and Dissertations

We explored the capabilities of additive manufacturing using a photo-cured jetted material 3D printer to manufacture a milli-microfluidic device with direct application in microalgae Dunaliella sp growth and intracellular compounds biosynthesis tests. A continuous microbioreactor for microalgae culture was CAD designed and successfully built in 1 hour and 49 minutes using black photopolymer cured by UV and a support material. The microreactor was made up of 2 parts including the bioreactor itself and a microchannel network for culture media fluids and microalgae. Both parts were assembled to form a single unit. Additional optical and auxiliar components were added. An external …

Neurosurgical Ultrasound Pose Estimation Using Image-Based Registration And Sensor Fusion - A Feasibility Study, Utsav Pardasani

Electronic Thesis and Dissertation Repository

Modern neurosurgical procedures often rely on computer-assisted real-time guidance using multiple medical imaging modalities. State-of-the-art commercial products enable the fusion of pre-operative with intra-operative images (e.g., magnetic resonance [MR] with ultrasound [US] images), as well as the on-screen visualization of procedures in progress. In so doing, US images can be employed as a template to which pre-operative images can be registered, to correct for anatomical changes, to provide live-image feedback, and consequently to improve confidence when making resection margin decisions near eloquent regions during tumour surgery.

In spite of the potential for tracked ultrasound to improve many neurosurgical procedures, it …

Developing Hyperpolarized Silicon Particles For In Vivo Mri Targeting Of Ovarian Cancer, Nicholas Whiting, Jingzhe Hu, Niki M. Zacharias, Ganesh L. R. Lokesh, David E. Volk, David G. Menter, Rajesha Rupaimoole, Rebecca Previs, Anil K. Sood, Pratip Bhattacharya

Nicholas Whiting

Characterization Of Left-Ventricular Thrombus Formation Using High Frequency Ultrasound, Kelsey A. Bullens, Arvin H. Soepriatna, Pavlos P. Vlachos, Craig J. Goergen

The Summer Undergraduate Research Fellowship (SURF) Symposium

Heart failure is a leading cause of death in the United States, and cardiac thrombus, a common morbidity associated with heart failure, significantly increases a patient’s risk of embolic events. The objective of this project is to characterize left-ventricular (LV) thrombus development using high frequency ultrasound imaging in a murine model. C57BL/6J wild-type mice (n=6) were injected intraperitoneally with iron dextran five times a week for six weeks to increase oxidative stress in the heart. Granulocyte-colony stimulating factor (G-CSF) was subcutaneously injected daily during the second week to initiate stem cell migration and stimulate endothelial cell activation, thus increasing the …

Control System For 3d Printable Robotic Hand, Htoo Wai Htet

Honors Theses

Humanoid robotics is a growing area of research due to its potential applications in orthosis and prosthesis for human beings. With the currently available technologies, the most advanced robotic hands used in prosthetics or robotics can cost from $11,000 to $90,000, making it inaccessible to the general population of amputees and robotics hobbyists. Most of the features provided by these expensive technologies are superfluous to many users, creating a great gap in cost and services between users and technology. Using the emerging 3D printing technology, my project is to construct a 3D printed robotic hand that can reproduce as many …

Calcium Phosphate As A Key Material For Socially Responsible Tissue Engineering, Vuk Uskoković, Victoria M. Wu

Pharmacy Faculty Articles and Research

Socially responsible technologies are designed while taking into consideration the socioeconomic, geopolitical and environmental limitations of regions in which they will be implemented. In the medical context, this involves making therapeutic platforms more accessible and affordable to patients in poor regions of the world wherein a given disease is endemic. This often necessitates going against the reigning trend of making therapeutic nanoparticles ever more structurally complex and expensive. However, studies aimed at simplifying materials and formulations while maintaining the functionality and therapeutic response of their more complex counterparts seldom provoke a significant interest in the scientific community. In this review …

Portable Sensory Room For The West Orange County Consortium For Special Education, Lindsey Chase, Emma Eskildsen, Alex Fox, Claire Francis, Nate Hoffman, Kaylee Keck, Sarah Sullivan

Biomedical Engineering

This report discusses the development of a Portable Sensory Room to be used at Newland Elementary School in Huntington Beach. Newland Elementary has an exceptional Special Needs program that teaches the children with the most severe cases of autism in its school district. People with autism typically also have sensory processing disorders, which can be extremely disruptive for a child’s development and can make it difficult for a child to be able to concentrate long enough to gain necessary life skills. The idea behind a Sensory Rooms is to create a place to calm the students and to expose them …

Essays In Physicians Preference Items And Inventory Management Within The Healthcare Supply Chain, Mohammad A. Shbool

Graduate Theses and Dissertations

This work is composed of a number of topics in the healthcare area, which are approached separately with appropriate methodologies. The two topics deal with physician preference items via two different approaches. The first one investigates stock keeping unit (SKU) proliferation in healthcare organizations due to physician preference items (PPI). It captures perspectives of physicians and supply chain professionals about this problem through two surveys. The second topic builds a decision-making framework for the PPI selection process that can be used by healthcare organizations to make more objective decisions. A Multi-criteria decision making technique is implemented to illustrate the framework.

Improving Reliability Of Medical Device Tracking Using Unique Device Identification, John A. Bonfanti

Industrial Engineering Undergraduate Honors Theses

The term “disruptive innovation” has been the buzzword of industries looking to create technological advancements in their respective fields ever since the term was first coined in 1995. In order to invest in the future of the industry, companies are beginning to focus on new, innovative ideas that come into the market as a low-cost alternative to the sustaining innovations currently in place. Similar business-models can be seen in the healthcare industry, as physicians look to disruptive innovations to provide methods of diagnosis and treatment that are easier to perform and maintain. Companies, from medical device manufacturers to the hospitals …

Diffusion Modeling And Device Development For Peritoneal Membrane Oxygenation, Liana Hatoum

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Acute respiratory distress syndrome (ARDS) is a pulmonary disease that causes hypoxemia and respiratory failure. The mortality rate for ARDS ranges between 27% and 45%. Current treatments including mechanical ventilation and extracorporeal membrane oxygenation (ECMO) are often associated with high risk complications including barotrauma, infection, thrombosis, and hemorrhage. Alternative pulmonary support techniques are needed to improve the survival rate of patients suffering from ARDS. Previous studies introducing pure O₂ gas, perfluorocarbons and red blood cells into the intraperitoneal (IP) cavity have reported no effect or only a mild increase in oxygenation. Here we report peritoneal membrane oxygenation (PMO) using …

A Study On Automated Process For Extracting White Blood Cellular Data From Microscopic Digital Injured Skeletal Muscle Images, Bibek Karki

UNLV Theses, Dissertations, Professional Papers, and Capstones

Skeletal muscle injury is one of the common injuries caused by high-intensity sports activities, military related works, and natural disasters. In order to discover better therapies, it is important to study muscle regeneration process. Muscle regeneration process tracking is the act of monitoring injured tissue section over time, noting white blood cell behavior and cell-fiber relations. A large number of microscopic images are taken for tracking muscle regeneration process over multiple time instances. Currently, manual approach is widely used to analyze a microscopic image of muscle cross section, which is time consuming, tedious and buggy.

Automation of this research methodology …

Design Of Medical Devices For Diagnostics In The Gastrointestinal System, Charles R. Welch

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

This thesis presents the design, controls, and testing of two systems: a novel colonoscope locomotion design for diagnostics, and a biosensor capsule that implants a sensor in the small intestine. Each system requires special design considerations for use in the gastrointestinal system.

Colonoscopy procedures are recommended as a screening for colon cancer and related conditions after the age of 50. The need for an improved colonoscope that reduces the colonoscopy time and patient discomfort is apparent. The semi-autonomous device presented here could likely reduce the colonoscopy procedure time by allowing the physician to focus more on the diagnosis and less …

Biomarkers Used To Detect And Monitor Neurological Autoimmune Diseases, Robert Powers, Jay Reddy, Teklab Gebregiworgis, Chandirasegara Massilamany, Arunakumar Gangaplara, Zsolt Illes

Robert Powers Publications

Biomarkers of neurological autoimmune diseases are described, and methods of using such biomarkers also are described.

Autoimmune diseases arise from an inappropriate immune response by the body against Substances or tissues normally found in the body. Neurological autoimmune diseases are those autoimmune diseases that affect some aspect of the neurological system (e.g., the central nervous system or the peripheral nervous system). Biomarkers of one or more neu rological autoimmune diseases, especially those biomarkers that can be evaluated non-invasively, are useful in the art. Biomarkers of neurological autoimmune diseases are pro vided, and methods of using Such biomarkers also are pro …

Compressive Sensing Framework For Mass Spectrometry Data Analysis, Khalfalla Ahmad Kh. Awedat

Dissertations

Mass Spectrometry (MS) data is ideal for identifying unique bio-signatures of diseases. However, the high dimensionality of MS data hinders any promising MS-based proteomics development. The goal of this dissertation is to develop an accurate classification tool by employing compressive sensing (CS). Not only can CS significantly reduce MS data dimensionality, but it also will allow for full reconstruction of original data. The framework developed in this work is based on using L2 and a mixed L2-L1 norms, allowing an overdetermined system to be resolved. The results show that the L2- based algorithm with regularization terms has a better performance …

Micro- And Nanoparticulates For Dna Vaccine Delivery, Eric Farris, Deborah M. Brown, Amanda Ramer-Tait, Angela K. Pannier

Biological Systems Engineering: Papers and Publications

DNA vaccination has emerged as a promising alternative to traditional protein-based vaccines for the induction of protective immune responses. DNA vaccines offer several advantages over traditional vaccines, including increased stability, rapid and inexpensive production, and flexibility to produce vaccines for a wide variety of infectious diseases. However, the immunogenicity of DNA vaccines delivered as naked plasmid DNA is often weak due to degradation of the DNA by nucleases and inefficient delivery to immune cells. Therefore, biomaterial-based delivery systems based on micro- and nanoparticles that encapsulate plasmid DNA represent the most promising strategy for DNA vaccine delivery. Microparticulate delivery systems allow …

Human Igg1 Antibodies Suppress Angiogenesis In A Target-Independent Manner, Sasha Bogdanovich, Younghee Kim, Takeshi Mizutani, Reo Yasuma, Laura Tudisco, Valeria Cicatiello, Ana Bastos-Carvalho, Nagaraj Kerur, Yoshio Hirano, Judit Z. Baffi, Valeria Tarallo, Shengjian Li, Tetsuhiro Yasuma, Parthasarathy Arpitha, Benjamin James Fowler, Charles B. Wright, Ivana Apicella, Adelaide Greco, Arturo Brunetti, Menotti Ruvo, Annamaria Sandomenico, Miho Nozaki, Ryo Ijima, Hiroki Kaneko, Yuichiro Ogura, Hiroko Terasaki, Balamurali K. Ambati, Jeanette H. W. Leusen, Wallace Y. Langdon, Michael R. Clark, Bradley D. Gelfand, Jayakrishna Ambati

Ophthalmology and Visual Science Faculty Publications

Aberrant angiogenesis is implicated in diseases affecting nearly 10% of the world’s population. The most widely used anti-angiogenic drug is bevacizumab, a humanized IgG1 monoclonal antibody that targets human VEGFA. Although bevacizumab does not recognize mouse Vegfa, it inhibits angiogenesis in mice. Here we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI (CD64) and c-Cbl, impairing macrophage migration. Other approved humanized or human IgG1 antibodies without mouse targets (adalimumab, alemtuzumab, ofatumumab, omalizumab, palivizumab and tocilizumab), mouse IgG2a, and overexpression of human IgG1-Fc or mouse IgG2a-Fc, also inhibited angiogenesis in wild-type …

Ortoqueratología En Defectos Hipermetrópicos, Ana Milena Peña Peña, Leidy Julieth Galindo Marroquin, Sergio Mario Garcia

Ciencia y Tecnología para la Salud Visual y Ocular

La ortoqueratología es una subespecialidad de la contactología por la que se adaptan lentes de contacto gaspermeables, que tiene como objeto la reducción temporal de los defectos visuales se ha demostrado que es un tratamiento eficaz para miopías y bajos astigmatismos, así como para defectos hipermetrópicos. Este artículo es una revisión bibliográfica de bases de datos y libros que describen y analizan los avances del funcionamiento de los lentes de ortoqueratología en la superficie ocular de hipermétropes a través del tiempo, los diseños de ortoqueratología en hipermetropía, los parámetros para la eficacia de este procedimiento y sus contraindicaciones y riesgos …

Biventricular Finite Element Modeling And Quantification Of 3d Langragian Strains And Torsion Using Dense Mri, Zhanqiu Liu

Theses and Dissertations--Mechanical Engineering

Statistical data suggests that increased use of evidence-based medical therapies has largely contributed to the decrease in American death rate caused by heart disease. And my studies are about two applications of magnetic resonance imaging (MRI) as a non-invasive approach in evidence-based health care research. In my first study, the achievement of a pulmonary valve replacement surgery was assessed on a patient with tetralogy of Fallot (TOF). In order to evaluate the remodeling of right ventricle, two biventricular finite element models were built up for pre-surgical images and post-surgical images. In my second study, 3D Lagrangian strains and torsion in …

Teleoftalmología Y Teleoptometría: Estrategias De Atención En Salud En Constante Avance, Johanna Sareth Acuña Gómez, Ivonne Cristina Guachamin Rodríguez, Natalia Fernanda Varela Suárez, Wilson Giovanni Jiménez Barbosa

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo: revisar la literatura que presente adelantos y experiencias que se han realizado en el campo de la teleoftalmología y la teleoptometría. Metodología: investigación de tipo documental que recurre a fuentes de datos secundarias, a través de la búsqueda en bases de datos como Hinari, ScienceDirect, Medline, Pubmed y, en particular, en revistas indexadas como American Journal of Public Health y Revista Cubana de Oftalmología. Resultados: se han presentado avances en la investigación, el desarrollo y la implementación de servicios, especialmente, de teleoftalmología y, en menor grado, de teleoptometría sin embargo, todos los estudios se han adelantado como experiencias …

Genética Del Glaucoma Primario De Ángulo Abierto, Vivian Alexandra Gutiérrez Carranza, Marcelo Carrizosa Murcia

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo conocer la genética del glaucoma primario de ángulo abierto para la identificación de genes que permitan establecer una herramienta de diagnóstico temprano para un mejor manejo de la enfermedad. Materiales y métodos se realizó una búsqueda sistematizada de literatura primaria en bases de datos como PubMed, SciELO y Elsevier además, se utilizaron referentes de varios textos para algunas terminologías, cuadros y tablas de los diferentes glaucomas, para determinar las características, el diagnóstico diferencial y la identificación de los genes asociados con el desarrollo del glaucoma primario de ángulo abierto. La información seleccionada corresponde al periodo 2010-2015. Conclusiones el glaucoma …

Recognizing Pain Using Novel Simulation Technology, Justin C. Grace

Honors Undergraduate Theses

Effective pain management and time to treatment is essential in patient care. Despite scientific evidence supporting the need to treat pain and an emphasis on addressing pain as a priority, pain management continues to be an unresolved issue. As a member of the health care team, nurses are integral to optimal pain management. Currently, nursing schools have limited innovative or alternative methods for teaching pain assessment and management. Simulation in nursing education provides a unique opportunity to expose students to realistic patient situations and allow them to learn and make mistakes without causing harm. However, modern low- and high-fidelity simulation …

Formación Bioética En Ciencias De La Salud, Nancy Piedad Molina Montoya

Ciencia y Tecnología para la Salud Visual y Ocular

Este artículo surgió del interés en los procesos de formación bioética en ciencias de la salud. Objetivos: identificar a partir de los cursos analizados los aspectos que motivan la enseñanza, los temas, las estrategias de enseñanza-aprendizaje (EEA) y de evaluación, así como algunas recomendaciones para el mejoramiento de los procesos de enseñanza y aprendizaje en el área. Metodología: búsqueda y selección de artículos en bases de datos: SciELO, PubMed y EBSCO. Resultados: se incluyeron 37 artículos e información complementaria de otros documentos. Conclusiones: los cursos responden a problemas éticos suscitados por el avance de la ciencia y la tecnología, transformaciones …

Propuesta Metodológica Para Determinar El Costo Final De Un Medicamento Intrahospitalario, Aura María Mojica Martínez, Wilson Giovanni Jiménez Barbosa, Marisol Núñez Antolinez, Diana Carranza Mojica, Lucy Paola Pedraza Muñoz, Daniela Cano Botero

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo diseñar una metodología que permita evaluar el impacto de los procesos que hacen parte de la cadena de valor del costo, facturado a terceros pagadores, por concepto de los medicamentos que tienen mayor participación dentro del total de la facturación de una institución de salud. Metodología se desarrolló a partir de la teoría de cadena de valor, definida por Michael Porter. Para ello, se realizó una primera etapa documental, en la que se establecieron, con base en la información reportada por una institución prestadora de servicios (IPS), los medicamentos que tienen mayor participación dentro de la facturación, a través …

Concordancia Entre Los Valores De Astigmatismo Obtenidos Con La Ley De Javal Y La Refracción Subjetiva., Héctor Aníbal Sánchez Montaña, Lina María Rodríguez Cely, Yuli Carolina Delgado Solarte

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo estimar el grado de concordancia entre los valores de astigmatismo obtenidos con las leyes de Javal y la refracción subjetiva en la población estudiantil de Pereira, en 2012. Materiales y métodos estudio descriptivo, correlacional y transversal, en el que se determinó utilizar el coeficiente de correlación-concordancia (CCC) para establecer el grado de astigmatismo mediante las leyes de Javal y la refracción subjetiva así mismo, se evaluaron los pacientes a través de queratometría, refracción meridional, emborronamiento y dial astigmático, por grupos quinquenales entre los 5 y los 19 años. En total fueron 915 estudiantes de Pereira. Resultados se valoraron 915 …

The Influence Of A Crosshair Visual Aid On Observer Detection Of Simulated Fetal Heart Rate Signals, Rebecca A. Kennedy, Mark W. Scerbo, Brittany L. Anderson-Montoya, Lee A. Belfore Ii, Alfred Z. Abuhamad, Stephen S. Davis

Psychology Faculty Publications

Objective To determine whether a visual aid overlaid on fetal heart rate (FHR) tracings increases detection of critical signals relative to images with no visual aid.

Study Design In an experimental study, 21 undergraduate students viewed 240 images of simulated FHR tracings twice, once with the visual aids and once without aids. Performance was examined for images containing three different types of FHR signals (early deceleration, late deceleration, and acceleration) and four different FHR signal-to-noise ratios corresponding to FHR variability types (absent, minimal, moderate, and marked) identified by the National Institute of Child Health and Human Development (2008). Performance was …

A New Technique To Improve The Operation Of Prosthetic Limbs During Muscle Fatigue, H. Albunashee, G. Rasool, K. Iqbal, G. White

Journal of the Arkansas Academy of Science

Prosthetic limbs hold a promise to renew the quality of life for the amputee. Neural commands are decoded via a classifier to generate control signals for the prosthetic devices. In the literature, many challenges and limitations have been identified that affect the prosthesis operation. One such drawback is muscle fatigue which degrades the surface electromyogram (sEMG) signals, and consequently, the performance of the deployed classification algorithm declines from 90% to 50% of average accuracy. We used a new technique using the Linear Discrimination Analysis (LDA) algorithm and the muscle synergy-based task discrimination (MSD) algorithm to improve the classification accuracy. In …

Estudio Sobre La Formación Del Optometrista En La Universidad Nacional Autónoma De México: Expectativas De Los Estudiantes De Último Semestre, Myrna Miriam Valera Mota, Eugenia Lucas Valerio, Mariana Guzmán Noriega

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo identificar las expectativas profesionales y laborales de los estudiantes de la licenciatura en Optometría de la Facultad de Estudios Superiores Iztacala, México. Materiales y métodos el estudio se realizó a través de entrevistas que permitieron identificar las expectativas de los estudiantes de último semestre de la carrera de Optometría. Los alumnos participantes se seleccionaron por conveniencia, es decir, se invitó a los tres grupos de octavo semestre a participar en la investigación y su decisión fue libre y sin obligaciones. Resultados se observa que los estudiantes desconocen el campo laboral y, por lo tanto, sus expectativas son vagas aunado …

Factores Que Influyen En La Omisión Del Reporte De Incidentes Y Eventos Adversos En Una Institución Acreditada De Tercer Nivel En Bogotá, Paula Andrea Rodríguez, Sandra P. Beltrán, Yeily Katherine Peña, María José Mendoza, Gisella Dayani Julio, Luisa Fernanda Giraldo Bernal

Ciencia y Tecnología para la Salud Visual y Ocular

El objetivo de este estudio es determinar los factores que contribuyen a la omisión del reporte del incidente o evento adverso, por parte del personal de salud, y caracterizar por unidad funcional la omisión del reporte para orientar las estrategias de intervención y mejorar la cultura de seguridad. El estudio es descriptivo-analítico. Para lo anterior, se tomó como población objeto al personal de salud de una institución acreditada de tercer nivel en Bogotá. El número total de encuestas se determinó por medio de la metodología de muestreo estadístico, que permite la recolección de los datos a partir de la aplicación …

Ciclosporina A Al 1 % En El Tratamiento Del Síndrome De Ojo Seco Moderado Y Severo, Martha Fabiola Rodríguez Álvarez, Alejandra Mendivelso, Carlos Medina

Ciencia y Tecnología para la Salud Visual y Ocular

La ciclosporina A es un inmunomodulador de uso tópico para el tratamiento del ojo seco su uso tiene acción terapéutica antiinflamatoria y pocos efectos adversos. Objetivo determinar cambios significativos en la sintomatología, la cantidad y la calidad de la película lagrimal y en el estado de la superficie ocular, después de tres meses de tratamiento con ciclosporina A al 1 %, en pacientes con ojo seco moderado y severo. Materiales y métodos: se desarrolló un estudio de intervención, controlado, ciego y aleatorizado, en 34 pacientes diagnosticados con ojo seco moderado y severo se administró, de manera aleatorizada, ciclosporina A al …

La Calidad De Vida Y La Salud, Ingrid Jiménez Barbosa

Ciencia y Tecnología para la Salud Visual y Ocular

No abstract provided.