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Using Light To Kill Cancer: Development Of A Novel Photodynamic Therapy, Alicia Hamilton Moore
Using Light To Kill Cancer: Development Of A Novel Photodynamic Therapy, Alicia Hamilton Moore
Honors Theses
Photodynamic therapy (PDT) is a treatment that uses special drugs called photosensitizing agents along with light to kill cancer cells. The specialized drugs only work after they have been activated or "turned on" by light. Photodynamic therapy may also be called photoradiation therapy, phototherapy, or photochemotherapy. In this research, I focused on the addition of four separate hydroxyl-amines to the unsubstituted porphyrin core, H2TPPC. The hydroxyl-amines attached to the porphyrin core were 5- amino-1-pentanol, 2-amino-2-ethyl-1, 3-propanediol, 3-amino-propanediol, and 5-aminovaleric acid. The novel water soluble PDT agents, H2TPP-A50H, H2TPP-2ET, H2TPP-3NH, and H2 …