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China Medical University

Noraristolodione; Cell cycle arrest; Apoptosis

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Bioactivities And Action Mechanisms Of Active Compounds From Hottuynia Cordata Thunb On Human Lung Cancer Cells, Yuh-Fung Chen, Wen-Hsin Chang, Huei-Yann Tsai, Min-Min Lee, Tian-Shung Wu May 2021

Bioactivities And Action Mechanisms Of Active Compounds From Hottuynia Cordata Thunb On Human Lung Cancer Cells, Yuh-Fung Chen, Wen-Hsin Chang, Huei-Yann Tsai, Min-Min Lee, Tian-Shung Wu

BioMedicine

Background: Lung cancer is the leading cause of death in Taiwan for years. Besides the currently used chemotherapy, herbal medicine may play a role in the treatment of lung cancer. Hottuynia cordata Thunb (HC), one of the frequently used herbal medicine in Taiwan, has been widely used in various diseases. Review from literatures, HC has many effects, including anti-inflammatory, anti-viral, anti-bacterial, anti-SARS, and anti-tumor activities. However, there is no literatures describe its active compounds on lung cancer. This present study aims to evaluate the possible effect and action mechanism of active compounds from HC (aristolactam BII, aristolactam AII, and …