Medicine and Health Sciences Commons^™

Psychiatric Comorbidity In Transformed Migraine: Presentation, Treatment, Impact And Outcome, Muhammad A. Abbas M.D, Haseeba Ismaiel, M.D, William B. Young M.D., Mary Hopkins, Stephen D. Silberstein, M.D

Jefferson Journal of Psychiatry

Transformed migraine is one of the subtypes of chronic daily headache (CDH), and is similar to chronic migraine, described in the new International Headache Society (IHS) classification 2004. The term CDH refers to the Headache disorders experienced 15 or more days a month and includes headaches associated with medication overuse. CDH can be divided into primary and secondary varieties. Primary CDH is not related to a structural or systemic illness. It includes diseases such as Transformed migraine (TM). Chronic tension-type headache (CTTH), new daily persistent headache (NDPH), and hemicrania continua (HC). Secondary CDH has an identifiable underlying cause, including post-traumatic …

Evolving Role Of Vorinostat Combined With Radiation Therapy In The Treatment Of Brain Tumors, From The Lab To The Clinic, Y. R. Lawrence, P. Wachsberger, Y. Liu, B. Andersen, A. P. Dicker

Bodine Journal

Purpose/Objective(s): Radiation therapy (RT) is a critical element in the treatment of both brain metastases and glioblastoma (GBM). Temozolomide (TMZ) has an established role in the upfront treatment of GBM. Down-regulated mismatch repair (MMR) is a known mechanism of resistance to TMZ. Vorinostat (SAHA), an HDAC inhibitor, has successfully been combined with a number of cytotoxic agents, including ionizing radiation (IR). We performed a series of preclinical and clinical studies to examine the role of SAHA in the treatment of brain tumors.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Uncertainty And Margin Study For Imrt, Vmat, And Proton Beam Therapy For Treatment After Radical Prostatectomy, Y. Cui, A. S. Harrison, M T. Studenski, T. N. Showalter, J. O. Deasy, Y. Yu, J. M. Galvin, Y. Xiao

Bodine Journal

Purpose/Objective(s): To compare the uncertainties of 3D dose distributions, caused by the geometrical uncertainty of patient setup, in IMRT, VMAT, and proton plans for post-prostatectomy treatment. To test the effectiveness of a common margin recipe in these three types of treatment plans.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Combination Of Vorinostat With Whole-Brain Radiotherapy In The Treatment Of Brain Metastases, Y. R. Lawrence, R. M. Pfeffer, M. Werner-Wasik, H. Choy, A. Dicker

Bodine Journal

Background: A third of patients with solid malignancies develop brain metastases. Expected overall survival is 4-7 months depending on age, performance status, and extracranial disease. Standard treatment is controversial; however, the majority of patients receive wholebrain radiation therapy at some point. Vorinostat (suberoylanilide hydroxamic acid, SAHA), an FDA-approved HDAC inhibitor, has been demonstrated to radiosensitize tumor cells in vitro, as assessed by both radiation-induced DNA damage and clonogenic cell survival (Munshi et al. Molecular Cancer Therapeutics 5, 1967-1974, 2006). We have shown that vorinostat downregulates key genes involved in double-strand DNA repair (Rad50, Rad51, XRCC2, XRCC3, XRCC6), as assessed by …

The Parents' Role In Childhood Obesity, Heather M. Wintrup

Psychology and Child Development

This paper is an examination of the current childhood obesity crisis in the U.S. and how this epidemic is related to psychological issues. Specifically, the role of parental forces on children’s health attitudes and habits is addressed. The following chapters will define and explain the current situation of childhood obesity, investigate the role parents have in contributing to their children’s weight development, and cover methods of intervention for families dealing with this serious health issue.

Composition And Methods For Treating Yersinia Pestis Infection, Susan C. Straley, Brian S. Murphy, Stanislav Forman, Christine R. Wulff, Robert D. Perry, Tanya Myers-Morales

Microbiology, Immunology and Molecular Genetics Faculty Patents

Compositions and methods for treating a Yersinia pestis (Y. pestis) infection are provided. Compositions and methods of for inducing an immune response in a subject are provided. Composition can include a YadC polypeptide.

Agmatine And Agmatine Analogs In The Treatment Of Epilepsy, Seizure, And Electroconvulsive Disorders, Peter A. Crooks, Aimee K. Bence, David R. Worthen

Pharmaceutical Sciences Faculty Patents

Pharmaceutical preparations containing of agmatine, congeners, analogs or derivatives thereof for use in preventing or treating epilepsy, seizures and other electroconvulsive disorders are provided. Embodiments include administering an effective amount of agmatine, an agmatine analog or a pharmaceutically acceptable salt thereof to a human subject in need of treatment or prevention of epilepsy, seizure or other electroconvulsive disorder to treat, reduce, or prevent the disorder in the subject.

Insulin Degrading Enzyme Assays For Treatment Of Alzheimer's Disease, Louis B. Hersh

Molecular and Cellular Biochemistry Faculty Patents

Estrogen has been shown to increase the expression and activity of amyloid peptide inactivating enzymes in the brain. Peptides have been shown to increase the activity of an amyloid peptide inactivating enzyme. Methods of identifying compounds for, and methods of treating patients with, Alzheimer's Disease is disclosed.

Comparison Of The Efficacy Of Enrofloxacin Against Escherichia Coli Or Pasteurella Multocida Infection In Chickens, Visut Rawiwet, Piyarat Chansiripornchai, Niwat Chansiripornchai

The Thai Journal of Veterinary Medicine

This study compared the efficacy of enrofloxacin, given immediately or 6 hrs after infection against Escherichia coli or Pasteurella multocida. In the first experiment, thirty, 12-week-old male layer chickens were divided into 3 groups of 10 each. Chickens in group 1, 2 and 3 were infected with E. coli serotype O78 by left thoracic air sac injection. Group 1 was given enrofloxacin (10 mg/kg), dissolved in drinking water immediately receiving E. coli. Group 2 was given enrofloxacin 6 hrs after receiving E. coli. Group 3 served as a positive control. In the second experiment, twenty, 16-week-old male layer chickens were …

Treatment Of Intracranial Aneurysms Using Detachable Coils; Initial Results At A University Hospital In Pakistan, Rana Shoaib Hamid, Tanveer-Ul-Haq, Ishtiaq Chishti, Muhammad Azeemuddin, Zafar Sajjad, Basit Salam

Department of Radiology

OBJECTIVE: To evaluate the technical success, safety and outcome of endovascular coiling procedure in intracranial aneurysms.

METHODS: From April 2003 to April 2009, 43 patients (23 males and 20 females), age range 11 to 70 years, mean age 46.67 +/- 11.57 years were treated for intracranial aneurysms by detachable coil deployment at Radiology Department of Aga Khan University Hospital. Aneurysm rupture with subarachnoid haemorrhage was the cause of presentation in 39 patients while 4 patients were diagnosed with un-ruptured aneurysms. At time of presentation, grading of subarachnoid haemorrhage was done according to Hunt and Hess grading system. Eleven patients presented …

Overview Of The Essential Tremor, Theresa A. Zesiewicz, Abinaya Chari, Israt Jahan, Amber M. Miller, Kelly L. Sullivan

Kelly L. Sullivan

Essential tremor (ET) is one of the most common movement disorders in the world. Despite this, only one medication (propranolol) is approved by the Food and Drug Administration (FDA) to treat it. Fortunately, recent studies have identified some additional medications as treatment of ET. Surgical procedures, such as deep brain stimulation of the ventral intermediate nucleus of the thalamus, offer treatment for refractory tremor. The epidemiology, pathogenesis, and medical and surgical treatment of ET will be discussed in this paper.

Sore Throat, Chris Del Mar, Paul Glasziou

Paul Glasziou

Abstract: This article considers the effects of interventions to reduce symptoms and complications of acute infective sore throat. It defines the condition and looks in detail at the areas of treatment, incidence, risk factors, methods and prognosis.

Women's Compliance In Outpatient Substance Abuse Treatment: The Role Of Children And Mental Health, Cathy Gertrude Cooke

Psychology Theses & Dissertations

The purpose of this study was to examine the role of children and mental illness in women's compliance in a treatment program for substance abuse. Information was retrieved from medical records of female clients ( N=221) who took part in a community-based day treatment program for substance abuse in a large city in southeastern Virginia during a 32-month period. It was anticipated that, as compared to women who resided with minor children, women who did not reside with minor children would have greater treatment success defined as: (1) more days in the treatment program; (2) higher percentage of negative …

Use Of Miltefosine In The Treatment Of Visceral Leishmaniasis In Children At A Tertiary Care Hospital Of Karachi, Khadija Nuzhat Humayun, Taimur Saleem, Umair Khalid, Fyezah Jehan, Sajid Soofi

Department of Paediatrics and Child Health

Existing standard treatment options for visceral leishmaniasis are less than optimal. We report here the use of oral miltefosine in the treatment of two paediatric cases of visceral leishmaniasis at a tertiary care hospital in Karachi, Pakistan. One patient came from Balochistan while the second patient was from Northern Pakistan. Both presented with a prolonged history of fever, massive hepatosplenomegaly, anaemia and thrombocytopenia. Visceral leishmaniasis was diagnosed with bone marrow studies. Amphotericin B was first started in the first patient; however severe hypokalaemia and allergic reaction occurred. Oral miltefosine was then administered. The child showed clinical improvement with regards to …

Methodological Considerations For Treatment Trials For Persons With Borderline Personality Disorder, Mary C. Zanarini, Barbara Stanley, Donald W. Black, John C. Markowitz, Marianne Goodman, Paul Pilkonis, Thomas R. Lynch, Kenneth Levy, Peter Fonagy, Martin Bohus, Joan Farrell, Charles A. Sanislow

Charles A. Sanislow, Ph.D.

BACKGROUND: The National Institute of Mental Health convened an international group of experts to examine the conduct of treatment trials for persons with borderline personality disorder (BPD). The rapid growth of treatment research had led to the recognition that investigators face unique methodological issues with these challenging patients.

METHODS: Conference members reviewed critical aspects of psychotherapy and pharmacotherapy trial design for patients with BPD.

RESULTS: This article summarizes discussions held on March 17-18, 2005.

CONCLUSION: This paper addresses the most pressing issues in sample selection and trial design pertaining to BPD; issues that have bedeviled both investigators submitting applications and …

Compositions And Methods Useful For Treating Circulatory And Hypovolemic Shock, Peter R. Oeltgen, Meera Govindaswami

Pathology and Laboratory Medicine Faculty Patents

Polypeptides, compositions, and methods for treating shock are described. A isolated polypeptide, Deltorphin-E, can be administered without concomitant fluid resuscitation, before, concurrently with, or after the onset of shock or the occurrence of an event that creates a risk of shock. Deltorphin-E can be administered in accordance with the method as part of a preconditioning strategy, which reduces the extent of ischemic injury. Deltorphin-E can be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.

Pemanfaatan Tanaman Obat Keluarga Di Kelurahan Tanah 600, Medan, Ulina Karo-Karo

Kesmas

Pemanfaatan Tanaman Obat Keluarga (TOGA) tidak hanya sebagai bumbu masakan dan obat, tetapi jika ditekuni dengan sepenuh hati akan memberi nilai kepuasan, bahkan sebagai penopang kehidupan. Penelitian kualitatif dengan metode ‘Individual’s life history’ pada satu keluarga yang telah memanfaatkan tanaman obat sejak lama di Tanah 600 Kecamatan Medan Marelan. Tujuan penelitian untuk mengetahui pengalaman satu keluarga yang berhasil memanfaatkan tanaman obat keluarga sebagai sumber pendapatan keluarga. Pengumpulan data dilakukan dengan teknik pengamatan dan wawancara mendalam. Penelitian dilakukan pada periode Februari-April 2009. Informan adalah Mak Intan, dilengkapi dengan keterangan suami, anak, menantu dan orang lain yang mengenal Mak Intan. Analisis data …

South, Lillian Harreld, 1879-1966 (Sc 2180), Manuscripts & Folklife Archives

MSS Finding Aids

Finding aid only for Manuscripts Small Collection 2180. Application to secure historical highway marker for Bowling Green, Kentucky native Lillian H. South, a female physician with a distinguished career as State Bacteriologist with the Kentucky State Board of Health. Includes application and supporting material.

Ct And Mri Features Following Uterine Fibroid Embolization, Sachit Verma Md, Carin F. Gonsalves Md, Oksana H. Baltarowich Md, Donald G. Mitchell Md, Anna Lev-Toaff Md, Diane Bergin Md

Department of Radiology Faculty Papers

Uterine artery embolization (UAE) is an effective treatment for symptomaticuterine fibroids. Magnetic resonance (MR) imaging is typically employed to evaluate the uterus following UAE for fibroid infarction, size, location change, persistent enhancement, changes in adenomyosis and uterine necrosis. Variable pattern of calcification on computed tomography (CT) can differentiate embolic particles and fibroid involution. CT following UAE may be requested because of acute pelvic pain or chest discomfort or pyrexia and/or for complications that may require treatment in acute phase. Visualization of gas in uterus and uterine vessels following UAE is an expected finding that should not be misinterpreted as a …

Preattentive Visual Search (Pavs): A Clinical Tool For Glaucoma, James Loughman

Books/Book chapters

Glaucoma is known to cause peripheral field loss but its impact is often underestimated. The inability to detect a target in an isolated area of the visual field may not be perceived as a significant disability. The determination here however that glaucoma adversely affects an individual’s capacity to deploy attention is an important one. This can be applied to infer the potential impact of the condition on lifestyle, even in the absence of diffuse perimetric field loss. Everyday tasks such as searching for car keys may prove more tedious and require more serial inspection. The ability to guide attention is …

Role Of Fesoterodine In The Treatment Of Overactive Bladder, Kylie J. Mansfield

Graduate School of Medicine - Papers (Archive)

Abstract: Muscarinic receptors have long been the target receptors for treatment of patients with overactive bladder (OAB). These patients experience symptoms of urgency, urinary frequency and nocturia, with or without urge incontinence (the involuntary leakage of urine associated with urge). Fesoterodine, a pro-drug, structurally and functionally related to tolterodine, is the newest agent developed for the treatment of OAB. Fesoterodine is broken down to the active metabolite, 5-hydroxy-methyl-tolterodine (5-HMT) by non-specific esterases. This metabolism results in the complete breakdown of the parent compound and is responsible for dose related improvements in clinical efficacy and health related quality of life. Like …

Alcohol Withdrawal: Syndrome And Treatment, D. Lalitanantpong

Chulalongkorn Medical Journal

ปัญหาผู้ติดสุรา เป็นปัญหาสุขภาพที่พบบ่อยในประเทศไทย ผู้ติดสุราอาจจะหยุดดื่มสุราด้วยสาเหตุหลาย ๆ อย่าง อาจจะตั้งใจหยุดเอง หรือเกิดจากความจำเป็น เนื่องจากเจ็บป่วยด้วยอุบัติเหตุหรือ โรคทางอายุรกรรม เฉียบพลัน ซึ่งผลการหยุดสุราทันทีหลังทีจากดื่มมาเป็นเวลานาน ก็จะเกิดกลุ่มอาการถอนสุราขึ้นกลุ่มอาการถอนสุรา แบ่งเป็นระดับความรุนแรง เป็นแบบไม่มีโรคแทรกซ้อน กับมีโรคแทรกซ้อนซึ่งระดับรุนแรงไม่มาก มักจะไม่มีอันตรายและหายได้เอง ส่วนระดับรุนแรงมาก มักจะประกอบด้วยกลุ่มอาการ 3 ชนิด ได้แก่ โรคลมชักเนื่องจากการถอนสุรา โรคจิตที่เกิดจากการใช้สุรา และโรค Deliriumที่เกิดจากการถอนสุราเนื่องจากผู้ดื่มสุราเป็นเวลานาน มักจะมีโรคประจำตัวทางอายุรกรรมอื่นร่วมด้วย โดยเฉพาะอย่างยิ่งโรคตับเรื้อรัง นอกจากนี้ผู้ป่วยอาจจะป่วยด้วยโรคทางอายุรกรรมขณะที่มีอาการถอนสุราดังนั้น การประเมินผู้ป่วย การวางแผนรักษา การเฝ้าระวังติดตามอาการอย่างใกล้ชิดจึงมีความสำคัญมากบทความนี้ได้ทบทวน สาเหตุของการเกิด Alchol tolerance และการถอนสุรา อธิบายการดำเนินโรคของกลุ่มอาการถอนสุรา การวินิจฉัยและการวินิจฉัยแยกโรค การตรวจทางห้องปฏิบัติการแนวทางในการรักษาผู้ป่วยถอนพิษสุรา ข้อบ่งชี้ในการรับรักษาในโรงพยาบาล วิธีประเมินความรุนแรงของภาวะถอนสุรา ขั้นตอนการให้ยารักษา และการเฝ้าระวังความเสี่ยงต่าง ๆ.

Hydatid Cyst Disease Of The Thorax, Saulat H. Fatimi, Naima Waqar Butt, Taimur Saleem, Mohammad Asim Beg

Section of Cardiothoracic Surgery

Hydatid disease is a frequently encountered entity in endemic areas and constitutes a serious health problem. The lung is the second most commonly affected organ after the liver. In three of four cases of pulmonary hydatid cyst, the cyst is solitary. The early phase after primary infection is always asymptomatic. Primary symptoms in patients with pulmonary cystic echinococcosis include cough, fever, and chest pain. The clinical and radiological manifestations for the hydatid cyst in the lung depend on the integrity of the cyst. Bronchial fistulization is an important event in the evolution of the cyst. In cases of dubious orientation …

Examining The Impact Of California's Medical Marijuana Program On Public Health, John C. Lamb

CMC Senior Theses

The debate surrounding marijuana legalization has increased its popularity in recent years, as the state of California seriously considers the complete legalization of the substance for those ages 21 and over. This would make California the first government in recorded history to regulate the cultivation and sale of marijuana on a commercial level. Advocates back the economic positives concerning high tax revenues, but those opposed argue that the dangers associated with public health greatly outweigh any monetary gain. The present study attempts to reveal the possible public health concerns, even potential benefits, caused by marijuana use and its distribution. Specifically, …

Social Cognition And Interaction Training (Scit) For Individuals With Schizophrenia Spectrum Disorders In Outpatient Treatment Settings, Petra Kleinlein

Department of Psychology: Dissertations, Theses, and Student Research

The role of social cognition in severe mental illness (SMI) has gained much attention, especially over the last decade. The impact of deficits in socio-cognitive functioning has been found to have detrimental effects on key areas of day-to-day functioning in individuals with SMI, such as gaining and maintaining employment and overall experienced quality of life. Treatment of individuals with SMI is challenging, as the presentation of individual signs and symptoms is rather heterogeneous. There are several treatment approaches addressing deficits ranging from broader social and interpersonal functioning to neurocognitive and more intrapersonal functioning. As research in the domain of social …

Nasal Squamous Cell Carcinoma In A Cow, Ali Baniadam, Navid Moezzi, Babak Mohammadian

Turkish Journal of Veterinary & Animal Sciences

A patient with a turgid, hemorrhagic mass infected by myiasis in the left nostril and diagnosed as squamous cell carcinoma (SCC) is presented. Complete blood count (CBC) showed moderate neutrophilia and eosinophilia and vital signs were in normal range. After aseptic surgical preparations and local anesthesia, the mass removed en bloc and submitted to the Department of Veterinary Pathology for histopathological evaluation. SCC was recognized microscopically by identifying malignant epithelial cells demonstrating various degrees of differentiation towards keratinocytes.

Periodontal Disease And Adverse Pregnancy Outcomes: Treatment Recommendations For The Pregnant Patient, Tabitha Price

ETSU Faculty Works

No abstract provided.