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Konsep Diagnosis Dan Penatalaksanaan Fraktur Osteoporosis Terkini, I Gusti Ngurah Wien Aryana, Febyan Febyan

Jurnal Penyakit Dalam Indonesia

Osteoporosis is a metabolic bone disease that is caused by a decreased amount of bone mass, and microarchitectural damage to bone tissue that affects the bone to break easily. Osteoporosis can be divided into primary and secondary etiologies. Vertebral, hip, distal radius, and proximal humerus are the most common predilection of fracture complication due to osteoporosis. The diagnosis of osteoporotic fractures is established based on the identification of risk factors, general clinical manifestations, specific manifestation from each fracture predilection, and advanced examinations, including radiology imaging and dual-energy x-ray absorptiometry. The purpose of osteoporotic fractures management in elderly is a stable …

Oxidative Stress-Related Biomarkers As Forensic Biomarkers For Burned Skin Vitality In Rats, Ola A. Habotta, Ahmed Ateya, Ahmed Abdeen, Iman Ibrahim, Mohamed M. Badawy, Ahmed M. Zeina

Mansoura Veterinary Medical Journal

Objective: In forensic practice, the diagnosis of whether a skin injury is inflicted in life or not is a challenging research topic. Therefore, new reliable biomarkers of vitality are urgently required. In this study, biochemical, molecular and histopathological techniques were used to explore the role of oxidative stress biomarkers in differentiating antemortem from postmortem burn injury. Design, animals and procedures: Eighteen male rats were allocated to three groups: normal unburnt group, antemortem burn group and postmortem burn group. Results: The analysis of skin specimens revealed a notable increase in MDA levels together with a decrease in GSH and TAC in …

Innovations In Surgery Between The Past And Future: A Narrative Review Of Targeted Literature, Obada Hasan, Ahmed Ayaz, Laiba Masood, Abdul Mannan Baig, Naveed Baloch

Medical College Documents

Innovation is the introduction of a new method or technology designed to change the way things are done. History is full of remarkable innovations in surgery over the years as surgeons have always been innovating and pioneering latest techniques and equipment that can benefit the mankind. Though persistent, progress has been far from uniform. Despite all the bells and whistles that these innovations bring to the table, the little acknowledged fact is that they are only accessible to a very small proportion of the global population. Five billion people on this planet do not even have access to an operating …

Topical Formulations Based On Polyhexamethylene Hydrochloride Guanidine For Surgicalfield Antisepsis, Fernanda Gosuen Gonçalves Dias, Renato Luis Tame Parreira, Lucas De Freitas Pereira, Rodrigo Cássio Sola Veneziani, Maria Anita Lemos Vasconcelos Ambrósio, Vinícius Thomaz Da Silva Almeida, Renata Alves De Barros, Luis Gustavo Gosuen Gonçalves Dias, Sérgio Ricardo Ambrósio

Turkish Journal of Veterinary & Animal Sciences

As surgical site infection can prolong the patient's hospital stay, increase morbidity and mortality rates and medical and hospital expenses, justifying the search for new effective and low-cost antiseptic drugs is justifiable. Thus, the objective of the present study was to analyze, by direct clinical and microbiological examination, the topical antiseptic effect of a solution based on polyhexamethylene hydrochloride guanidine (PHMGH) at 0.5% on the intact skin surface of sheep and cats, aiming at its use in operative field (previous and definitive antisepsis), compared to 0.5% alcoholic chlorhexidine and association with this. The topical solutions did not cause any skin …

Cranial Cruciate Ligament Desmotomies In Sheep Resulting In Peroneus Tertius Injury, Peter J. Welsh, Crystal G. Collier, Holly M. Clement, Michael N. Vakula, Jeffrey B. Mason

Animal, Dairy, and Veterinary Science Student Research

Surgical destabilization of the stifle joint via cranial cruciate ligament desmotomy (CCLD) is a routine procedure for the study of osteoarthritis (OA). Traditionally performed in rats, rabbits, cats, and dogs, CCLD in sheep provides an opportunity to study the pathology and treatment of joint instability in a species whose stifle better represents the equivalent human femorotibial joint. The surgical approaches for CCLD in sheep are variable and can result in inconsistent outcomes. Eight sheep underwent CCLD for use in a gene therapy study. We report this case in which six of the eight sheep were clinically diagnosed by pathognomonic signs …

Comparison Of Estimated Glomerular Filtration Rate Using Five Equations To Predict Acute Kidney Injury Following Hip Fracture Surgery, Efstratios A. Papadelis, Kevin L. Mekkawy, Yash P. Chaudhry, Micheal Raad, Raj M. Amin, Harpal S. Khanuja

Research Day

Introduction: Hip fractures are a common injury and a source of disability and mortality in the aging population. Acute kidney injury (AKI) is a common and potentially serious complication following hip fracture surgery. Estimated glomerular filtration rate (eGFR) is used as an indicator of renal function. Several equations are commonly used to calculate eGFR. The purpose of this study was 1) to evaluate the agreement between five equations in calculating eGFR, and 2) to confirm which equation can best predict AKI in patients undergoing hip fracture surgery.

Methods: 146,702 cases of surgical stabilization of hip fracture were queried from the …

Special Considerations In Facial Transplantation: A Systematic Review, Melanie Shpigel, Sammy Othman, Jason Cohn, Christopher Hill, Paige Bundrick, Gabriel F. Santiago, Chad Gordon

Research Day

Background: Vascularized composite allotransplantation (VCA) of the face is an exceedingly complex procedure, requiring extensive planning and surgical precision in order to successfully manage patients with facial disfigurements. This review aims to present an overview of the salient anatomic considerations in facial transplantation, as well as give attention to unique patient populations and special considerations.

Methods: A literature review was performed in search of articles pertaining to considerations in facial transplantation using the databases PubMed, Web of Science, and Cochrane. Articles selected for further review included full-text articles with an emphasis on specific anatomic defects and how they were addressed …

Soft Tissue Chondroma Of The Thumb, Harsha Upadhya, Darshdeep Singh

Research Day

A chondroma is a slow-growing, benign cartilaginous tumor. When a chondroma occurs in soft tissue without any involvement of the surrounding bone, it is known as a soft tissue chondroma which is an especially rare type of malignancy that has a predilection for the hands and feet. A soft tissue chondroma originates from either the synovial sheath of long tendons, para-articular tissues, or paratendinous soft tissues. This type of tumor can often be misdiagnosed as several different pathologies, including but not limited to, a ganglion cyst, osteochondroma, synovial chondromatosis, or even malignant examples such as a chondrosarcoma or synovial sarcoma. …

Paula Ferrada, M.D. Facs Trauma And Acute Care Surgery (Interview), Joseph Mceachon

Osmosis Magazine

Interview by Joseph McEachon

Titles at VCU: Professor of Surgery at VCU.

Program Director for the Surgical Critical Care Fellowship.

Medical Director of the Surgical and Trauma Intensive Care Unit.

Dermatology Technique: Mohs Micrographic Surgery, Michelle J. Volis

Mako: NSU Undergraduate Student Journal

This paper aims to educate the readers about a novel surgery approach that is becoming popular among dermatologists. This technique, Mohs surgery, is implemented in order to treat malignant skin cancer types. This paper incorporates the history of Mohs micrographic surgery, the advantages and disadvantages of the procedure, and alternatives to this approach. The main advantage is healthy tissue preservation while disadvantages include holes in fragmented tissue margins and tissue orientation complications.

The Management Of Perioperative Immunosuppressant Medications For Rheumatoid Arthritis During Elective Hand Surgery, Kevin M. Klifto, Brian H. Cho, Scott D. Lifchez

Research Day

Purpose: Rheumatoid arthritis (RA) is a destructive inflammatory disease that commonly involves joints of the hand and wrist. Different recommendations exist for continuing or discontinuing immunosuppressant medications during the perioperative time period. The purpose of our study was to determine if continuing steroids, non-biologic DMARDs, and/or biologic DMARDs were associated with an increased risk of postoperative complications.

Methods: We performed a single-centered, retrospective review of a consecutive cohort of RA patients who had elective hand surgery by a single surgeon. Patients were included if they had a documented diagnosis of seropositive RA by a rheumatologist, and had elective …

Early Oral Feeding After Bowel Resection, Jennifer Strang

Theses & Dissertations

Research Focus: The primary purpose of this project was to determine if there was an association of factors with time to first solid meal in gastrointestinal (GI) surgery patients and the impact solid diet has on length of stay (LOS) in the hospital, GI symptoms, and incidence of post-operative ileus (POI). A secondary purpose was to observe and describe when an oral diet was started and the progression of diet after GI surgery.

Research Methods: This study was a cross-sectional, retrospective chart review of a convenience sample in a multi-centered hospital system conducted in 84 GI resection patients …

Infection Of A Ventricular Septal Defect Patch With Acremonium Species, Nosheen Nasir, Kauser Jabeen, Joveria Farooqi, Binish Arif Sultan, Afia Zafar, Aamir Hameed Khan, Muneer Amanullah, Farheen Ali

Section of Internal Medicine

A ventricular septal defect (VSD) patch infection with Acremonium species isolated from vegetation and blood culture is described. Antifungal treatment was discontinued after 3 months and patient developed relapse. Surgery with prolonged oral voriconazole was instituted with recovery. We emphasize importance of surgery and prolonged therapy to treat such infections.

A Comparison Of Angiography Versus Intravascular Ultrasound In The Treatment Of Peripheral Arterial Disease, Michael Pompliano

Senior Theses

Peripheral Arterial Disease is a growing epidemic throughout the United States. It is estimated that 8 to 12 million Americans currently suffer from PAD, a disease of the circulatory system that limits blood flow to your hands and feet. This limited blood flow is due to the narrowing of the arteries that supply blood throughout your body and can disrupt the balance of the nerves and tissues that make up your extremities. If left untreated, it can cause irreparable, life- threatening damage that may result in amputation of the diseased limb. Although the mechanism of PAD is known and well …

The Treatment Of Congenitally Developed Fused Vulva Labia In A Brown-Swiss Heifer, Oktay Yilmaz, Ebubeki̇r Yazici, Mehmet Uçar, Muhammed Kürşad Bi̇rdane

Turkish Journal of Veterinary & Animal Sciences

A case of congenitally developed fused labia in a 13-month-old Brown-Swiss heifer, an uncommon entity, is described. On gross appearance of vulva, it was observed that there were only 2 small openings in the dorsal and ventral vulvar commissures. Ultrasonography of the genital tract revealed the presence of left and right ovaries, uterine horns, and cervix uteri. The abnormality of the vulva was surgically corrected. The heifer was synchronized and artificially inseminated postsurgically. During delivery, no complication was observed and a healthy male calf was born. To the authors' knowledge, this is the first report describing both the surgical treatment …

Molecular Imaging To Target Transplanted Muscle Progenitor Cells, Kelly Gutpell, Rebecca Mcgirr, Lisa Hoffman

Anatomy and Cell Biology Publications

Duchenne muscular dystrophy (DMD) is a severe genetic neuromuscular disorder that affects 1 in 3,500 boys, and is characterized by progressive muscle degeneration(1, 2). In patients, the ability of resident muscle satellite cells (SCs) to regenerate damaged myofibers becomes increasingly inefficient(4). Therefore, transplantation of muscle progenitor cells (MPCs)/myoblasts from healthy subjects is a promising therapeutic approach to DMD. A major limitation to the use of stem cell therapy, however, is a lack of reliable imaging technologies for long-term monitoring of implanted cells, and for evaluating its effectiveness. Here, we describe a non-invasive, real-time approach to evaluate the success of myoblast …

A New Model For Partial Immobilization Of Rat Hind Limb After Achilles Tendon Excision/Reinterposition, Cansin Güngörmüş, Mehmet Alper Çeti̇nkaya, Alper Demi̇rutku

Turkish Journal of Veterinary & Animal Sciences

There have been several attempts to repair the Achilles tendon by surgery or replacement with graft materials. Because tissue repair is a complex process, tendon healing occurs slowly. In rats, immobilization of the limb is essential during recovery. There are immobilization methods such as plaster or fiber casting. According to prolonged recovery, most of the procedures cause skin ulceration, decrease in weight, restrictions in checking the surgery area, and slipping out of the cast. Our aim was to apply a suture around the defect for immobilization. Tendons of 30 male Wistar rats (250 ± 50 g and aged 8 ± …

Heterotopic Ossification: Cellular Basis, Symptoms, And Treatment, Brian Wolfe

Senior Honors Theses

Heterotopic ossification (HO) is the process by which calcified bone develops in soft tissues. Because of the abnormal calcification, complications such as bone deformation, loss of range of motion, and joint immobility adversely affect patients. There are many genetic types of heterotopic ossification, namely fibrodysplasia ossificans progressiva, progressive osseous heteroplasia, and Albright hereditary osteodystrophy. However, this condition can also arise from surgery, burns, or traumatic injuries, so it is seen as an important area for research in the future. There are various treatments available such as non-steroidal anti-inflammatory drugs and radiation therapy, as well as combinations of the two. The …

Amputation Of Vibrissae In Show Dogs, Thomas E. Mcgill

Veterinary Science and Medicine Collection

Dogs of many different breeds competing in the show-ring are routinely subjected to amputation of the vibrissae, organs that are commonly and incorrectly called "whiskers." This procedure is thought to give the animal's head a cleaner look, which in turn supposedly increases its chances of winning. There are several tricks involved in "whisker trimming" since the animals can retract each vibrissae at least one-quarter inch. Furthermore, they often object strenuously to the operation.