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Articles 1 - 16 of 16
Full-Text Articles in Medicine and Health Sciences
Inducible Nitric Oxide Synthase Embedded In Alginate/Polyethyleneimine Hydrogel As A New Platform To Explore No-Driven Modulation Of Biological Function, Shaimaa Maher, Lauren A. Smith, Celine A. El-Khoury, Haitham F. Kalil, Khalid Sossey-Alaoui, Mekki Bayachou
Inducible Nitric Oxide Synthase Embedded In Alginate/Polyethyleneimine Hydrogel As A New Platform To Explore No-Driven Modulation Of Biological Function, Shaimaa Maher, Lauren A. Smith, Celine A. El-Khoury, Haitham F. Kalil, Khalid Sossey-Alaoui, Mekki Bayachou
Chemistry Faculty Publications
Nitric oxide (NO), a small free radical molecule, turned out to be pervasive in biology and was shown to have a substantial influence on a range of biological activities, including cell growth and apoptosis. This molecule is involved in signaling and affects a number of physiologic functions. In recent decades, several processes related to cancer, such as angiogenesis, programmed cell death, infiltration, cell cycle progression, and metastasis, have been linked with nitric oxide. In addition, other parallel work showed that NO also has the potential to operate as an anti-cancer agent. As a result, it has gained attention in cancer-related …
Synthesis Of Alginate/Hydroxyapatite Beads For Acetaminophen Delivery, Anesylvia Angan, Nonni Soraya Sambudi
Synthesis Of Alginate/Hydroxyapatite Beads For Acetaminophen Delivery, Anesylvia Angan, Nonni Soraya Sambudi
Makara Journal of Science
Conventional drug delivery systems usually involve the intake of multiple drugs, which could amplify the risk of overdosing. Acetaminophen is a widely used pain relief substance that is prone to accidental overdosing. Hence, a controlled drug delivery system is needed to ensure its efficacy. A nanocomposite hydroxyapatite/alginate system that was used as a drug carrier for acetaminophen was synthesized through the sol-gel method, and the mechanism underlying its controlled drug delivery was investigated. Spherical nanocomposite bead samples were synthesized by incorporating 5 wt%, 10 wt%, and 15 wt% hydroxyapatite into mixtures containing alginate. The mixtures were then dropped into calcium …
Zein And Lignin-Based Nanoparticles As Delivery Systems: Pesticide Release And Nanoparticle Health Impact On Soybean Plants, Fallon Polette Salinas Gonzalez
Zein And Lignin-Based Nanoparticles As Delivery Systems: Pesticide Release And Nanoparticle Health Impact On Soybean Plants, Fallon Polette Salinas Gonzalez
LSU Doctoral Dissertations
This research examined the effect of biodegradable, polymeric, lignin-based nanoparticles (LNPs, 113.8±3.4, negatively charged) and zein nanoparticles (ZNP, 141.6±3.9, positively charged) on soybean plant health. The LNPs were synthesized from lignin, covalently linked to poly(lactic-co-glycolic) acid by emulsion evaporation. ZNPs were synthesized by nanoprecipitation. Soybeans grown hydroponically were treated with three concentrations (0.02, 0.2, and 2 mg/ml) of NPs at 28 days after germination. The effect of ZNPs and LNPs on plant health was determined through analysis of root and stem length, chlorophyll concentration, dry biomass of roots and stem, as well as carbon, nitrogen, and micronutrient absorption after 1, …
Organic Cation Transporter 3 And The Dopamine Transporter Differentially Regulate Catecholamine Uptake In The Basolateral Amygdala And Nucleus Accumbens, Katherine M. Holleran, Jamie H. Rose, Steven C. Fordahl, Kelsey C. Benton, Kayla E. Rohr, Paul J. Gasser, Sara R. Jones
Organic Cation Transporter 3 And The Dopamine Transporter Differentially Regulate Catecholamine Uptake In The Basolateral Amygdala And Nucleus Accumbens, Katherine M. Holleran, Jamie H. Rose, Steven C. Fordahl, Kelsey C. Benton, Kayla E. Rohr, Paul J. Gasser, Sara R. Jones
Biomedical Sciences Faculty Research and Publications
Regional alterations in kinetics of catecholamine uptake are due in part to variations in clearance mechanisms. The rate of clearance is a critical determinant of the strength of catecholamine signaling. Catecholamine transmission in the nucleus accumbens core (NAcc) and basolateral amygdala (BLA) is of particular interest due to involvement of these regions in cognition and motivation. Previous work has shown that catecholamine clearance in the NAcc is largely mediated by the dopamine transporter (DAT), but clearance in the BLA is less DAT‐dependent. A growing body of literature suggests that organic cation transporter 3 (OCT3) also contributes to catecholamine clearance in …
Bmp And Tgfß Use And Release In Bone Regeneration, Zeynep Bal, Junichi Kushioka, Joe Kodama, Takashi Kaito, Hideki Yoshikawa, Petek Korkusuz, Feza Korkusuz
Bmp And Tgfß Use And Release In Bone Regeneration, Zeynep Bal, Junichi Kushioka, Joe Kodama, Takashi Kaito, Hideki Yoshikawa, Petek Korkusuz, Feza Korkusuz
Turkish Journal of Medical Sciences
A fracture that does not unite in nine months is defined as nonunion. Nonunion is common in fragmented fractures and large bone defects where vascularization is impaired. The distal third of the tibia, the scaphoid bone or the talus fractures are furthermore prone to nonunion. Open fractures and spinal fusion cases also need special monitoring for healing. Bone tissue regeneration can be attained by autografts, allografts, xenografts and synthetic materials, however their limited availability and the increased surgical time as well as the donor site morbidity of autograft use, and lower probability of success, increased costs and disease transmission and …
Double Deletion Of Panx1 And Panx3 Affects Skin And Bone But Not Hearing, J M. Abitbol, B L. O'Donnell, C B. Wakefield, E Jewlal, J J. Kelly, K Barr, K E. Willmore, B. L. Allman, S Penuela
Double Deletion Of Panx1 And Panx3 Affects Skin And Bone But Not Hearing, J M. Abitbol, B L. O'Donnell, C B. Wakefield, E Jewlal, J J. Kelly, K Barr, K E. Willmore, B. L. Allman, S Penuela
Anatomy and Cell Biology Publications
Pannexins (Panxs), large-pore channel forming glycoproteins, are expressed in a wide variety of tissues including the skin, bone, and cochlea. To date, the use of single knock-out mouse models of both Panx1 and Panx3 have demonstrated their roles in skin development, bone formation, and auditory phenotypes. Due to sequence homology between Panx1 and Panx3, when one Panx is ablated from germline, the other may be upregulated in a compensatory mechanism to maintain tissue homeostasis and function. To evaluate the roles of Panx1 and Panx3 in the skin, bone, and cochlea, we created the first Panx1/Panx3 double knock-out mouse model (dKO). …
Extracellular Adenosine 5'-Triphosphate And Lipopolysaccharide Induce Interleukin-1Β Release In Canine Blood, Mari Spildrejorde, Stephen J. Curtis, Belinda L. Curtis, Ronald Sluyter
Extracellular Adenosine 5'-Triphosphate And Lipopolysaccharide Induce Interleukin-1Β Release In Canine Blood, Mari Spildrejorde, Stephen J. Curtis, Belinda L. Curtis, Ronald Sluyter
Faculty of Science, Medicine and Health - Papers: part A
Binding of extracellular adenosine 5′-triphosphate (ATP) or lipopolysaccharide (LPS) to the damage-associated molecular pattern receptor P2X7 or the pathogen-associated molecular pattern receptor Toll-like receptor (TLR)4, respectively, can induce the release of the pleiotropic cytokine interleukin (IL)-1β in humans and mice. However, the release of IL-1β in dogs remains poorly defined. Using a canine IL-1β enzyme-linked immunosorbent assay, this study investigated whether ATP or LPS could induce IL-1β release in a canine blood-based assay. Short-term incubations (30 min) with ATP induced IL-1β release in LPS-primed canine blood, and this process could be near-completely impaired by the P2X7 antagonist, A438079. In contrast, …
Selective Release Of Potent N-Alkylisatin Based Cytotoxins Via Hydrolysis Of Ph Sensitive Imine Linkers, D Skropeta, L Matesic, J Locke, K Vine, M Ranson, J Bremner
Selective Release Of Potent N-Alkylisatin Based Cytotoxins Via Hydrolysis Of Ph Sensitive Imine Linkers, D Skropeta, L Matesic, J Locke, K Vine, M Ranson, J Bremner
Danielle Skropeta
No abstract provided.
Effect Of Nrf2 Activators On Release Of Glutathione, Cysteinylglycine And Homocysteine By Human U373 Astroglial Cells, Megan L. Steele, Stacey Fuller, Mili Patel, Cindy Kersaitis, Lezanne Ooi, Gerald Munch
Effect Of Nrf2 Activators On Release Of Glutathione, Cysteinylglycine And Homocysteine By Human U373 Astroglial Cells, Megan L. Steele, Stacey Fuller, Mili Patel, Cindy Kersaitis, Lezanne Ooi, Gerald Munch
Faculty of Science, Medicine and Health - Papers: part A
Neurons rely on the release and subsequent cleavage of GSH to cysteinylglycine (CysGly) by astrocytes in order to maintain optimal intracellular GSH levels. In neurodegenerative diseases characterised by oxidative stress, neurons need an optimal GSH supply to defend themselves against free radicals released from activated microglia and astroglia. The rate of GSH synthesis is controlled largely by the activity of γ-glutamyl cysteine ligase. Expression of γ-glutamyl cysteine ligase and of the Xc- system, which facilitates cystine uptake, is regulated by the redox-sensitive transcription factor, nuclear factor erythroid-2-related factor 2 (Nrf2). Compounds that can activate the Nrf2-ARE pathway, referred to as …
Prolonged Clinical Effects In Modified-Release Amitriptyline Poisoning, Niall O'Connor, S Greene, Paul Dargan, Duncan Wyncoll, Alison Jones
Prolonged Clinical Effects In Modified-Release Amitriptyline Poisoning, Niall O'Connor, S Greene, Paul Dargan, Duncan Wyncoll, Alison Jones
Alison L Jones
Background. Tricyclic antidepressant poisoning is often associated with significant cardiovascular and central nervous system toxicity. Effective treatment includes the use of appropriate gastric decontamination techniques, the administration of sodium bicarbonate, and meticulous supportive care. Tricylcic antidepressant toxicity typically lasts 24–48 hours following a significant overdose. Case Report. We describe a case of tricyclic antidepressant poisoning where significant clinical toxicity (QRS prolongation, metabolic acidosis) was observed for up to 4 days following ingestion of a modified-release preparation of amitriptyline. Successful patient recovery was associated with the use of multidose activated charcoal and repeated administration of intravenous sodium bicarbonate. Conclusions. Clinicians should …
Porcine Bladder Urothelial, Myofibroblast And Detrusor Muscle Cells: Characterisation And Atp Release, Ying Cheng, Kylie J. Mansfield, Shaun L. Sandow, Prajni Sadananda, Elizabeth Burcher, Kate H. Moore
Porcine Bladder Urothelial, Myofibroblast And Detrusor Muscle Cells: Characterisation And Atp Release, Ying Cheng, Kylie J. Mansfield, Shaun L. Sandow, Prajni Sadananda, Elizabeth Burcher, Kate H. Moore
Graduate School of Medicine - Papers (Archive)
ATP is released from the bladder mucosa in response to stretch, but the cell types responsible are unclear. Our aim was to isolate and characterize individual populations of urothelial, myofibroblast, and detrusor muscle cells in culture, and to examine agonist-stimulated ATP release. Using female pig bladders, urothelial cells were isolated from bladder mucosa following trypsin-digestion of the luminal surface. The underlying myofibroblast layer was dissected, minced, digested, and cultured until confluent (10–14 days). A similar protocol was used for muscle cells. Cultures were used for immunocytochemical staining and/or ATP release investigations. In urothelial cultures, immunoreactivity was present for the cytokeratin …
Hormone Induction Of Gamete Release And In-Vitro Fertilization In The Critically Endangered Corroboree Frog, Phillip G. Byrne, A J Silla
Hormone Induction Of Gamete Release And In-Vitro Fertilization In The Critically Endangered Corroboree Frog, Phillip G. Byrne, A J Silla
Illawarra Health and Medical Research Institute
Background: Conservation Breeding Programs (CBP's) are playing an important role in the protection of critically endangered anuran amphibians, but for many species recruitment is not successful enough to maintain captive populations, or provide individuals for release. In response, there has been an increasing focus on the use of Assisted Reproductive Technologies (ART), including the administration of reproductive hormones to induce gamete release followed by in vitro fertilisation. The objective of this study was to test the efficacy of two exogenous hormones to induce gamete release, for the purpose of conducting in vitro fertilisation (IVF), in one of Australia's most critically …
Atp Release During Cystometry In Women With Detrusor Overactivity And Painful Bladder Syndrome: Contribution To 'Urgency'?, Elizabeth Burcher, Kylie J. Mansfield, W Allan, C Walsh, Kate H. Moore, Ying Cheng
Atp Release During Cystometry In Women With Detrusor Overactivity And Painful Bladder Syndrome: Contribution To 'Urgency'?, Elizabeth Burcher, Kylie J. Mansfield, W Allan, C Walsh, Kate H. Moore, Ying Cheng
Graduate School of Medicine - Papers (Archive)
ATP is an important signalling molecule whose release from the bladder urothelium in response to stretch is thought to stimulate afferent nerves and thus convey information about bladder fullness (and the sensation of urgency). Our aim was to measure the release of ATP during urodynamic filling of bladders of women with idiopathic detrusor overactivity (DO), painful bladder syndrome (PBS) and stress incontinence (controls), in order to test the hypothesis that ATP release might play a role in bladder function and/or dysfunction.
Acid, But Not Capsaicin, Is An Effective Stimulus For Atp Release In The Porcine Bladder Mucosa, Prajni Sandananda, Kylie J. Mansfield, Elizabeth Burcher
Acid, But Not Capsaicin, Is An Effective Stimulus For Atp Release In The Porcine Bladder Mucosa, Prajni Sandananda, Kylie J. Mansfield, Elizabeth Burcher
Graduate School of Medicine - Papers (Archive)
Hypothesis / aims of study: Urothelial ATP release is thought to play an important role in bladder afferent signaling via activation of purinergic receptors on suburothelial afferent nerves. Stretch of the bladder mucosa is a well documented stimulus for ATP release in several species, including the pig [1]. In addition, in mouse bladder, capsaicin is also an effective stimulus for ATP release, acting via stimulation of vanilloid (TRPV1) receptors [2]. While acid is an agonist at the TRPV1 receptor, specialized acid sensing ion channels (ASICs) are also present in several organ systems [3]. Our aim was to characterize the ATP …
Fatality After Deliberate Ingestion Of Sustained-Release Ibuprofen: A Case Report, David Wood, Jane Monaghan, Peter Streete, Alison L. Jones, Paul Dargan
Fatality After Deliberate Ingestion Of Sustained-Release Ibuprofen: A Case Report, David Wood, Jane Monaghan, Peter Streete, Alison L. Jones, Paul Dargan
Faculty of Science, Medicine and Health - Papers: part A
Introduction Ibuprofen is a nonsteroidal anti-inflammatory drug available over the counter and on prescription for the management of pain and inflammation. Severe toxicity is rare following deliberate self-poisoning with ibuprofen, and patients are usually either asymptomatic or develop only mild gastrointestinal toxicity. Although there have been nine other reported fatalities, co-existent factors have probably contributed to all of these deaths. We report here a fatality from isolated toxicity following self-poisoning with sustained-release ibuprofen. Case report A 26-year-old female presented after deliberate ingestion of up to 105 g sustained-release ibuprofen, with a reduced level of consciousness, severe metabolic acidosis and haemodynamic …
Effect Of Escherichia Coli And Lactobacillus Rhamnosus On Macrophage Inflammatory Protein 3Α, Tumor Necrosis Factor Alpha, And Transforming Growth Factor Β Release By Polarized Rat Uterine Epithelial Cells In Culture, M. A. Crane-Godreau, C. R. Wira
Effect Of Escherichia Coli And Lactobacillus Rhamnosus On Macrophage Inflammatory Protein 3Α, Tumor Necrosis Factor Alpha, And Transforming Growth Factor Β Release By Polarized Rat Uterine Epithelial Cells In Culture, M. A. Crane-Godreau, C. R. Wira
Dartmouth Scholarship
Entry of bacteria from the vagina into the uterus raises the question of uterine epithelial cell (UEC) signaling in response to the presence of bacteria. Our model system helps to define microbially elicited UEC basolateral cytokine release, important in regulating underlying stromal immune cell protection. UECs from adult rats were grown in cell culture inserts to establish a confluent polarized monolayer as was determined by transepithelial resistance (TER). Polarized epithelial cell cultures were treated apically with live or heat-killed Escherichia coli or Lactobacillus rhamnosus prior to collection of basolateral media after 24 h of incubation. Coculture of polarized UECs with …