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Full-Text Articles in Medicine and Health Sciences

Precision Medicine & Public Health: How The All Of Us Program Can Make Us All Healthier, Benjamin Barber May 2022

Precision Medicine & Public Health: How The All Of Us Program Can Make Us All Healthier, Benjamin Barber

Virginia Journal of Public Health

No abstract provided.


Exploring Extension Agent Capacity And Readiness To Adopt Policy, Systems And Environmental Change Approaches, Lisa T. Washburn, Heather Norman-Burgdolf, Natalie Jones, Lauren E. Kennedy, Soghra Jarvandi May 2022

Exploring Extension Agent Capacity And Readiness To Adopt Policy, Systems And Environmental Change Approaches, Lisa T. Washburn, Heather Norman-Burgdolf, Natalie Jones, Lauren E. Kennedy, Soghra Jarvandi

Dietetics and Human Nutrition Faculty Publications

Introduction: Enhanced Extension outreach strategies combine traditional direct education programs with public health approaches like policy, systems, and environmental (PSE) change. However, the Cooperative Extension system and county-based Family and Consumer Sciences (FCS) Extension agents have historically prioritized direct education programming and diffusion of enhanced outreach strategies has varied. Extension personnel may lack capacity and readiness for successful PSE change implementation. This study explored perceived acceptability, capacity, and readiness for PSE change work among FCS Extension agents in two states.

Method: A survey was developed framed by selected domains from the Consolidated Framework for Implementation Research: Intervention Characteristics, Inner Setting, …


Effect Of Bovine Lactoferrin On Seroconversion Following Polio Vaccine Administration In Children: Protocol For A Double-Blinded Randomised Controlled Trial, Atif Habib, Sidrah Nausheen, Shanila Nooruddin, Tooba Javed, Tariq Samejo, Amjad Hussain, Suneeta Namdave, Sehrish Amirali, Muhammad Umer, Lumaan Sheikh May 2022

Effect Of Bovine Lactoferrin On Seroconversion Following Polio Vaccine Administration In Children: Protocol For A Double-Blinded Randomised Controlled Trial, Atif Habib, Sidrah Nausheen, Shanila Nooruddin, Tooba Javed, Tariq Samejo, Amjad Hussain, Suneeta Namdave, Sehrish Amirali, Muhammad Umer, Lumaan Sheikh

Department of Paediatrics and Child Health

Introduction: The oral polio vaccine (OPV) has substantial results in eliminating wild poliovirus and the vaccine of choice in polio eradication. However, the mucosal immunity induced by the OPV is still uncertain. Literature has shown that bovine lactoferrin (BLF) is a safe and useful protein found in cow's milk with extraordinary antimicrobial, antiviral, antiinflammatory and immune-modulatory functions that help children's gut to fight against micro-organisms like poliovirus. However, limited data exist regarding the effect of BLF on polio vaccine immune response. The primary objective is to evaluate the effect of BLF in enhancing mucosal and humoral immunity in children following …


Experiences Of Older Immigrants Living With Dementia And Their Carers: A Systematic Review And Meta-Synthesis, Pelden Chejor, Bridget Laging, Lisa Whitehead, Davina Porock May 2022

Experiences Of Older Immigrants Living With Dementia And Their Carers: A Systematic Review And Meta-Synthesis, Pelden Chejor, Bridget Laging, Lisa Whitehead, Davina Porock

Research outputs 2022 to 2026

Objective To systematically review and synthesise evidence on the experiences of older immigrants living with dementia and their carers. Design A systematic review and meta-synthesis of qualitative studies. Methods Studies exploring the experiences of older immigrants living with dementia and their carers were eligible. Databases were searched including CINAHL, MEDLINE, PsycINFO, PubMed, Embase, Web of Science and Cochrane Library from January 2000 to April 2021. Quality assessment was undertaken using the Critical Appraisal Skills Programme checklist for qualitative studies. Data were then synthesised using the thematic synthesis approach. Results The results of this meta-synthesis were reported according to the Preferred …


Determinants Of Domestic Violence Among Women Of Reproductive Age (15-49 Years) In Quetta, Balochistan-A Mixed-Method Protocol, Salman Muhammad Soomar, Sarmad Muhammad Soomar May 2022

Determinants Of Domestic Violence Among Women Of Reproductive Age (15-49 Years) In Quetta, Balochistan-A Mixed-Method Protocol, Salman Muhammad Soomar, Sarmad Muhammad Soomar

Department of Emergency Medicine

Background: Worldwide, domestic violence (DV) is a cause of death and disability among women aged 15-49 years. In Pakistan, DV appears in different forms, and only 3.2% of women report any DV. There are various factors associated with DV against women. The data are sparse for the Balochistan province due to the under-reporting and scattered population. This research study aims to determine the factors associated with DV and the types of violence among women of reproductive age. Also, to understand the perspective of community leaders and healthcare workers (HCWs) for developing interventions for DV prevention against women of reproductive age …


Systematic Review Protocol Of The Effectiveness Of Hiv Prevention Interventions For Reducing Risky Sexual Behaviour Among Youth Globally, Fungai Mbengo, Maggie Zgambo, Ebenezer Afrifa-Yamoah, Fatch Welcome Kalembo, Takanori Honda, Yoko Shimpuku, Sanmei Chen May 2022

Systematic Review Protocol Of The Effectiveness Of Hiv Prevention Interventions For Reducing Risky Sexual Behaviour Among Youth Globally, Fungai Mbengo, Maggie Zgambo, Ebenezer Afrifa-Yamoah, Fatch Welcome Kalembo, Takanori Honda, Yoko Shimpuku, Sanmei Chen

Research outputs 2022 to 2026

INTRODUCTION:

Human immunodeficiency virus (HIV) prevention interventions focused at reducing risky sexual behaviours are an important strategy for preventing HIV infection among youth (15-24 years) who continue to be vulnerable to the disease. This systematic review aims to synthesise current global evidence on the effectiveness of HIV prevention interventions for reducing risky sexual behaviour among youth in the last decade.

METHODS AND ANALYSIS:

MEDLINE/PubMed, EMBASE, PsychINFO, ProQuest Central, CINAHL and Web of Science databases, ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform and reference lists of included studies and systematic reviews on effectiveness of HIV prevention interventions for reducing …


Hepatitis C Treatment For Substance Users In North Dakota, Janae Arnold May 2022

Hepatitis C Treatment For Substance Users In North Dakota, Janae Arnold

Physician Assistant Scholarly Project Papers

In the 1960’s, the hepatitis C virus (HCV) epidemic began mainly through the transmission of blood transfusions. By the time screening was implemented, millions had already become infected worldwide. After a decade of declining infection rates, a second wave started in the midst of the opioid epidemic in 2010. Prior to 2014 and the application of curative direct-acting antivirals, treatment was expensive, had low efficacy, many side effects, and long treatment durations. Advances in medicine have allowed for HCV elimination with shorter treatment durations, less side effects, and higher treatment rates. Unfortunately, treatment is not offered to all HCV patients …


Institute Of Public Health Newsletter- Volume3, Issue2, Institute Of Public Health (Iph) May 2022

Institute Of Public Health Newsletter- Volume3, Issue2, Institute Of Public Health (Iph)

Institute of Public Health Newsletter (IPHNL) and Other Publications

Volume 3, Issue 2 (May August 2022)


Taking A User-Centered Design Approach To Develop A Data Dashboard For New York State Department Of Health And Implications For Improving The Usability Of Public Data Dashboards / Narrative Competence And Cognitive Mapping As A Culturally Sustaining Pedagogy In The Education Of Emergent Bilinguals, Bahareh Ansari May 2022

Taking A User-Centered Design Approach To Develop A Data Dashboard For New York State Department Of Health And Implications For Improving The Usability Of Public Data Dashboards / Narrative Competence And Cognitive Mapping As A Culturally Sustaining Pedagogy In The Education Of Emergent Bilinguals, Bahareh Ansari

Legacy Theses & Dissertations (2009 - 2024)

In recent years, the increased availability of public data dashboards provided opportunities to democratize data access by summarizing large amounts of data into accessible snapshots to facilitate educational efforts and encourage evidence-based decision-making. However, many current practices have not reached their full potential because the dashboard design has not accounted for users’ needs and preferences. This dissertation employed the user-centered design framework with three studies. Study 1 investigated the usability problems of existing public health data dashboards through an expert review of existing dashboards on government websites. Study 2 established the requirements of a usable design for public health data …


The Communicative Capacities Of The Medical Discourse In Authoritarian Societies : The Case Of Aids In Iran, Elham Pourtaher May 2022

The Communicative Capacities Of The Medical Discourse In Authoritarian Societies : The Case Of Aids In Iran, Elham Pourtaher

Legacy Theses & Dissertations (2009 - 2024)

This study explores the role of medical discourse in the Iranian formal public sphere. It examines how an epidemiological wave of HIV/AIDS—known as "the third wave"—highlighted nontraditional sexual behaviors in public and enabled a shift in policy and discourse by the Islamic Republic State. Through analyzing published content on HIV/AIDS from five major Iranian newspapers between 2009 and 2013, this study identified four competing narratives of the third wave which coexist and have a dynamic relationship with one another. First, the medical narrative warns of an unfolding public health crisis and provides a technical perspective to make sense of the …


Agility And Focus Save The Day, Eddy Kusnadi Sariaatmadja, Chin Tiong Tan May 2022

Agility And Focus Save The Day, Eddy Kusnadi Sariaatmadja, Chin Tiong Tan

Asian Management Insights

Eddy Kusnadi Sariaatmadja, Founder and President Commissioner of Indonesia’s PT Elang Mahkota Teknologi (Emtek), tells Tan Chin Tiong how the company not only survived, but thrived during the COVID-19 pandemic.


Beyond The Covid-19 Pandemic, Havovi Joshi May 2022

Beyond The Covid-19 Pandemic, Havovi Joshi

Asian Management Insights

As COVID-19 infection rates stabilise throughout the world, countries have already begun to prepare for life beyond the pandemic. In this issue, leading academics and seasoned practitioners walk us through the challenges that lay before us, giving us insights into issues from public health and regulations revolving around Artificial Intelligence (AI) and automation, to challenges faced in implementing digital transformation and their implications for lives, livelihood, and society as we tread gingerly into the post-COVID-19 world.


Factors Associated With Telemedicine Usage And Acceptance Pre- And Since Covid-19, Shivangi Sinha May 2022

Factors Associated With Telemedicine Usage And Acceptance Pre- And Since Covid-19, Shivangi Sinha

Calvert Undergraduate Research Awards

The COVID-19 pandemic has acted as a catalyst for telemedicine uptake among healthcare providers and patients. Prior research rarely has examined the lack of patient uptake of telemedicine. Known systemic barriers to accessing telemedicine in the U.S. before the COVID-19 pandemic may play a large role in its uptake. The purpose of this study is to assess the factors associated with the usage and acceptance of telemedicine pre- and since the COVID-19 pandemic. In this cross-sectional study, data was collected from persons residing within the U.S. who are 18 years of age or older using an online survey. Using an …


Exploring Higher Weight Women's Experiences Of Provider Weight Stigma, Meredith W. Moore May 2022

Exploring Higher Weight Women's Experiences Of Provider Weight Stigma, Meredith W. Moore

Graduate Theses and Dissertations

The purpose of this phenomenological study is to explore the phenomena of weight stigma as experienced by higher weight women in mental health treatment who also engage in restrictive eating behaviors. Women in larger bodies who are emotionally or behaviorally restrictive in their eating behaviors face a unique set of challenges and barriers. These include challenges due the disordered eating behaviors themselves, along with barriers related to weight stigma perpetuated by the mental health providers treating them (Harrop, 2019). Distinct hurdles to proper treatment including delay of diagnosis, longer duration of symptoms, and increased distress related to eating and body …


Six Feet Apart: Relational Turbulence Theory And Coping With Covid-19 Within Long-Distance Relationships, Mia Waymack May 2022

Six Feet Apart: Relational Turbulence Theory And Coping With Covid-19 Within Long-Distance Relationships, Mia Waymack

Graduate Theses and Dissertations

Among research that currently exists, no studies thus far combine elements of COVID-19, long-distance relationships, and Relational Turbulence Theory to explain how each of these elements impacts the others, if at all. Previous research does exist on each of these elements individually, although research regarding the long-term effects of COVID-19 on relationships is minimal considering the pandemic is ongoing. Long-distance relationships have been studied using Relational Turbulence Theory in previous studies within military relationships but have not been studied in connection with either COVID-19 or among college students. This study was conducted by way of qualitative, one-on-one interviews to determine …


Exploring The Relationship Between Healthcare Access And Cancer Diagnosis, Kara Mccurdy Apr 2022

Exploring The Relationship Between Healthcare Access And Cancer Diagnosis, Kara Mccurdy

Health Sciences Student Scholarship

Kara McCurdy ’22
Major: Health Policy and Management
Minors: Mathematics and French
Faculty Mentor: Dr. Candidus Nwakasi, Health Policy and Management

Cancer affects millions of Americans each year and is one of the leading causes of death; social determinants of health play an important role in not only the prevention of cancer, but the prevalence of cancer among certain groups in our population. As one of the most prominent public health concerns, examining why cancer affects some more than others is an important part of prevention. Many people in the US lack access to healthcare due to costs and other …


Review Of Diabetes Among Aboriginal And Torres Strait Islander People, Katherine Ride, Samantha Burrow Apr 2022

Review Of Diabetes Among Aboriginal And Torres Strait Islander People, Katherine Ride, Samantha Burrow

Journal of the Australian Indigenous HealthInfoNet

Diabetes is the fastest growing chronic disease condition globally. Type 2 diabetes in particular, has reached epidemic proportions, with the greatest burden falling on socially disadvantaged groups and Indigenous peoples.

This review focuses primarily on type 2 diabetes among Aboriginal and Torres Strait Islander people, which is responsible for the majority of cases of diabetes in this population. It provides general information on the social and cultural context of diabetes, and the behavioural and biomedical factors that contribute to diabetes among Aboriginal and Torres Strait Islander people.

This review provides detailed information on:

  • the extent of diabetes among Aboriginal and …


The Impact Of Afghan Opium Cultivation On The U.S. Opioid Epidemic, Zachary Wahab Cheek Apr 2022

The Impact Of Afghan Opium Cultivation On The U.S. Opioid Epidemic, Zachary Wahab Cheek

UNL Student Research Days Posters, Undergraduate

I argue here that increases in Afghan opium cultivation, the most prolific in the world, has depressed American prescription opioid and heroin prices, thereby increasing abuse risk in U.S. addict populations and increasing death rates. Utilizing a two-stage regression model with a sparse dataset from several national and international sources, I find evidence that a one percent increase in Afghan opium production is associated with a 0.122 percent increase in prescription opioid overdose deaths, and a 0.367 percent increase in heroin overdose deaths. Assessing the 2001-2002 Taliban opium ban with an identification strategy, I find that in this timeframe prescription …


Sleep Health Of Australian Community Tennis Players During The Covid-19 Lockdown, Philipp Beranek, Travis Cruickshank, Olivier Girard, Kazunori Nosaka, Danielle Bartlett, Mitchell Turner Apr 2022

Sleep Health Of Australian Community Tennis Players During The Covid-19 Lockdown, Philipp Beranek, Travis Cruickshank, Olivier Girard, Kazunori Nosaka, Danielle Bartlett, Mitchell Turner

Research outputs 2022 to 2026

Background: Poorer sleep health outcomes have been documented in the general population during the COVID-19 outbreak. However, the impact of the COVID-19 outbreak on sleep health outcomes in specific population groups, including the sporting community, has not been extensively investigated. This study evaluated sleep health outcomes and their relationship with lifestyle behaviours during the initial COVID-19 lockdown period in Australian community tennis players. Methods: This cross-sectional study evaluated sleep health outcomes and lifestyle behaviours using an online survey. The survey was disseminated online between the 24th of April and the 6th of June 2020 and comprised the Sleep Health Index, …


Building First‑Year Medical Students’ Skills In Finding, Evaluating, And Visualizing Health Information Through A “Debunking Medical Myths” Curricular Module, Katherine Akers, Ella Hu, Narmeen Rehman, Ho Jun Yun, Jacob Hoofman, Rachel Monconduit, Jennifer Mendez Apr 2022

Building First‑Year Medical Students’ Skills In Finding, Evaluating, And Visualizing Health Information Through A “Debunking Medical Myths” Curricular Module, Katherine Akers, Ella Hu, Narmeen Rehman, Ho Jun Yun, Jacob Hoofman, Rachel Monconduit, Jennifer Mendez

Internal Medicine Faculty Publications

To provide an online service learning opportunity for medical students during the COVID-19 pandemic, medical faculty and librarians developed and implemented a “Debunking Medical Myths” module in which students learned to search for emerging medical literature, evaluate evidence, and use that evidence to create an infographics debunking a COVID-19-related myth for a non-medical audience. The resultant infographics are visually appealing and designed to make complex health information easy to understand. The module was well-received by students, who demonstrated a nuanced understanding of the use of infographics to convey health information, and students’ work was evaluated highly by community members.


Maximising Access To Timely Trauma Care Across Population Of Karachi And Its Districts: A Geospatial Approach To Develop A Trauma Care Network, Muhammad Nabeel Ashraf, Mohammad Salman Khalil, Ahwaz Akhtar, Lubna Samad, Asad Latif Apr 2022

Maximising Access To Timely Trauma Care Across Population Of Karachi And Its Districts: A Geospatial Approach To Develop A Trauma Care Network, Muhammad Nabeel Ashraf, Mohammad Salman Khalil, Ahwaz Akhtar, Lubna Samad, Asad Latif

Department of Anaesthesia

Objectives: To develop and propose a cost-effective trauma care network for Karachi, Pakistan, by calculating maximum timely trauma care (TTC) coverage achieved with the addition of potential designated private and public level 1 and level 2 trauma centres (TCs).
Setting: A lower middle-income country metropolis, Karachi is Pakistan's largest city with a population of 16 million and a total of 56 hospitals as per government registry data.
Participants: 41 potential TCs selected using a two-level, contextually-relevant TC designation criteria adapted from various international guidelines.
Primary and secondary outcome measures: Maximum TTC coverage achievable with the addition of potential TCs. Proposed …


Institute Of Public Health Newsletter- Volume3, Issue1, Institute Of Public Health (Iph) Apr 2022

Institute Of Public Health Newsletter- Volume3, Issue1, Institute Of Public Health (Iph)

Institute of Public Health Newsletter (IPHNL) and Other Publications

No abstract provided.


Healthcare Safety-Net In The United States: Patient Satisfaction Across Rural And Urban Hospitals, Vivian Ho Apr 2022

Healthcare Safety-Net In The United States: Patient Satisfaction Across Rural And Urban Hospitals, Vivian Ho

Senior Theses

Objective. To examine rurality and other hospital characteristics associated with patient satisfaction across hospitals in the United States.

Data. Nationwide hospital data from the 2019 Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey and the 2020 Centers for Medicare & Medicaid Services (CMS) Provider of Services (POS) file.

Study Design. Hospital ZIP-codes were categorized into urban, rural micropolitan, or small/isolated rural based on Rural-Urban Commuting Area (RUCA) codes. Patient satisfaction measures from the HCAHPS survey were linked to the CMS POS data for hospital characteristics, yielding 2,357 urban, 749 rural micropolitan, and 1,343 small/isolated rural hospitals. ANOVA and …


Examining The Impacts Of Flooding On Public Health, Lauren Gibson Apr 2022

Examining The Impacts Of Flooding On Public Health, Lauren Gibson

Honors Theses

Over the past 10 years, South Carolina has experienced over five major weather events that have led to extreme flooding along the coast. These types of repeated major events have the potential to significantly impact people’s lives and livelihoods. When looking at the issue from a public health perspective, it is known that natural disasters such as flooding can negatively affect community health. However, little research has been done to analyze the impacts on individual health from flooding. This issue inspired a more in-depth research analysis to examine those health impacts from local Horry County residents. This research aims to …


“Pandemias Políticas: The Effects Of Political And Social Instability On Infectious Disease Epidemiology In Latin America"”, Sarah H. Noonan Apr 2022

“Pandemias Políticas: The Effects Of Political And Social Instability On Infectious Disease Epidemiology In Latin America"”, Sarah H. Noonan

Senior Theses

This paper seeks to analyze the relationship between political and social unrest and conflict and infectious disease epidemiology in Latin America. An analysis of published literature regarding epidemiological, biomedical, political, and historical content was conducted to highlight potential connections between infectious disease epidemics and sociopolitical conflict in the region. Specific analyses of Smallpox, Venezuelan Equine Encephalitis, Chagas disease, Cholera, Dengue, and COVID-19 were conducted, in an effort to uncover potential causations and context of epidemics of these conditions. Results of this analysis depict a necessity for further research into public health and disease control mechanisms during times of conflict and …


Evaluation Of Nitrite Concentration In Edible Bird’S Nest (White, Yellow, Orange, And Red Blood), Siti Gusti Ningrum, Bagus Uda Palgunad, Rochiman Sasmita Mar 2022

Evaluation Of Nitrite Concentration In Edible Bird’S Nest (White, Yellow, Orange, And Red Blood), Siti Gusti Ningrum, Bagus Uda Palgunad, Rochiman Sasmita

Makara Journal of Science

The color of edible bird’s nest is associated with its nitrite concentration, but this relationship remains inconclusive. This investigation aimed to evaluate the nitrite content in edible bird’s nest of four different colors: white, yellow, orange, and red blood. Fifty-eight edible bird’s nest samples were obtained from five swiftlet farmhouses in Borneo Island, Indonesia and analyzed for nitrite content using Genesys 30 visible spectrophotometer. Results showed that the dark-colored edible bird’s nests (yellow, orange, and red blood) had higher nitrite concentrations of 304, 317, and 309 ppm, respectively, compared with the white-colored one (15 ppm). Therefore, the color of edible …


Vaccine Hesitancy And The Apocalypse, David M. Claborn Mar 2022

Vaccine Hesitancy And The Apocalypse, David M. Claborn

eJournal of Public Affairs

Some forms of vaccine hesitancy may have roots in religious beliefs about future apocalyptic events. Such beliefs engender fear of centralized governmental authority as manifest in public health mandates involving vaccines or masks. The author’s upbringing as a religious survivalist provides perspective on why some people display vaccine hesitancy. Several ways to address these fears are discussed.


The Place Of Bodily Asceticism In A Nation’S Social Structure, Andrzej Pawlucki Mar 2022

The Place Of Bodily Asceticism In A Nation’S Social Structure, Andrzej Pawlucki

Baltic Journal of Health and Physical Activity

The hypothesis to be verified explains why bodily asceticism is excluded, owing to the influence of the ideologist, from the system of public health in the structure of a liberal cratocracy, in which reason is the good of the authority for its own sake. In the structure of national society, the system of bodily asceticism is raised to the status of community good. Despite the blocking of the connectivity of the system of bodily asceticism to the social structure, academic gymnasions survived the collapse of the state. Each of them independently excused itself with the idealess reason of the market …


Physical Activity Patterns And Dietary Habits Of Undergraduate Students, Ebenezer Essaw, Monday Omoniyi Moses, Daniel Afrifa, Isaac Kwaku Acheampong, Winifred Mensah, Lemuel Owusu Mar 2022

Physical Activity Patterns And Dietary Habits Of Undergraduate Students, Ebenezer Essaw, Monday Omoniyi Moses, Daniel Afrifa, Isaac Kwaku Acheampong, Winifred Mensah, Lemuel Owusu

Baltic Journal of Health and Physical Activity

Background: ‪Data about physical activity report card for Ghanaian children and youth are available but reports on physical activity patterns and dietary habits of undergraduates are scarce. Material and methods: ‪This cross-sectional study sampled 278 participants (161 males, 117 females, mean age = 20.73 ± 1.72 years). Blood pressure, heart rate, physical activity patterns and dietary habits were measured. Results: ‪Most (83.1%) of the sample predominantly engaged in household activities. Time spent on treadmill/ cycling activities is significantly higher in females than males (P = 0.018). Day/week for high intensity sports was higher in males (P = 0.005), while household …


American Heart Association's Life's Simple 7: Lifestyle Recommendations, Polygenic Risk, And Lifetime Risk Of Coronary Heart Disease, Natalie R Hasbani, Symen Ligthart, Michael R Brown, Adam S Heath, Allison Bebo, Kellan E Ashley, Eric Boerwinkle, Alanna C Morrison, Aaron R Folsom, David Aguilar, Paul S De Vries Mar 2022

American Heart Association's Life's Simple 7: Lifestyle Recommendations, Polygenic Risk, And Lifetime Risk Of Coronary Heart Disease, Natalie R Hasbani, Symen Ligthart, Michael R Brown, Adam S Heath, Allison Bebo, Kellan E Ashley, Eric Boerwinkle, Alanna C Morrison, Aaron R Folsom, David Aguilar, Paul S De Vries

Faculty, Staff and Students Publications

BACKGROUND: Understanding the effect of lifestyle and genetic risk on the lifetime risk of coronary heart disease (CHD) is important to improving public health initiatives. Our objective was to quantify remaining lifetime risk and years free of CHD according to polygenic risk and the American Heart Association's Life's Simple 7 (LS7) guidelines in a population-based cohort study.

METHODS: Our analysis included data from participants of the ARIC (Atherosclerosis Risk in Communities) study: 8372 White and 2314 Black participants; 45 years of age and older; and free of CHD at baseline examination. A polygenic risk score (PRS) comprised more than 6 …