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Hif-1 Activation And Inflammatory Responses To Hypoxia, Shazreen Shaharuddin, Nik Mohd Afizan Nik Abd Rahman, Mas Jaffri Masarudin, Mohammedarfat N Alamassi

International Journal of Aviation, Aeronautics, and Aerospace

Acute hypoxia is a significant physiological danger during high-altitude flying and military aircraft missions. The human brain requires a constant supply of oxygen to function properly, and is susceptible to settings with low availability of air oxygen. Hypoxia can influence inflammatory signalling, and both central and systemic responses can activate HIF pathway genes. HIFs are critical molecules that regulate inflammation andhypoxia, ensuring appropriate cell function and survival. Hypoxia is the condition in which insufficient oxygen reaches the body's tissues. It can be caused by a decrease in partial oxygen pressure (PO2) in the environment, problems with breathing and/or oxygen transport, …

The Impact Of 32 Days’ Exposure To Hypobaric Hypoxia On Physiological Cost Of Sub-Maximal Work Performed At The Sea Level, Sylwester Kujach, Tomasz Grzywacz, Ewa Ziemann, Robert Szymczak, Marcin Luszczyk, Radoslaw Laskowski

Baltic Journal of Health and Physical Activity

Background: Many papers showed that long-lasting exposure to hypobaric hypoxia changed the metabolic cost of work and substrate contribution, elevating exercise energy expenditure and carbohydrates utilization. Only few of them have shown how long this adaptive changes are maintained. The aim of the study was to assess the impact of prolonged sojourn at high altitude on the physiological cost of sub-maximal work performed at the sea level. Materials and methods: Eight members of two high altitude expeditions (Lenin Peak 7,134 m a.s.l. and Somoni Peak 7,495 m a.s.l.), 7 males and 1 female, mean age 26 (±4.1) years, volunteered for …

Incidence, Etiology, Sociodemographic And Clinical Characterization Of Acute Respiratory Failure In Pediatric Patients At A High-Altitude City: A Multicenter Cohort Study, Sarha M Vargas Muñoz, Sara De Vivero Haddad, Aldo M Beltran, Carolina Bonilla Gonzalez, Melisa Naranjo Vanegas, Sergio Moreno-Lopez, Paola Rueda-Guevara, Pedro Barrera, Juan Gabriel Piñeros, Luz Marina Mejía, María Lucia Mesa, Sonia Restrepo-Gualteros, Olga Lucía Baquero Castañeda, Andrea Ramírez Varela

Journal Articles

BACKGROUND: Acute respiratory failure is a life-threatening medical condition, associated with a variety of conditions and risk factors, including acute respiratory diseases which are a frequent cause of pediatric morbidity and mortality worldwide. In Colombia, the literature related to ARF is scarce.

OBJECTIVE: To determine the incidence, causes, and sociodemographic and clinical characteristics of ARF in three hospitals in Bogota, a high-altitude city located in Colombia, during the COVID-19 pandemic.

METHODS: A multicenter prospective cohort study called the FARA cohort was developed between April 2020 - December 2021. Patients older than one month and younger than 18 years with respiratory …

Findings Of Cognitive Impairment At High Altitude: Relationships To Acetazolamide Use And Acute Mountain Sickness., Lara Phillips, Buddha Basnyat, Yuchiao Chang, Erik R. Swenson, N. Stuart Harris

Department of Emergency Medicine Faculty Papers

Phillips, Lara, Buddha Basnyat, Yuchiao Chang, Erik R. Swenson, and N. Stuart Harris. Findings of cognitive impairment at high altitude: relationships to acetazolamide use and acute mountain sickness. High Alt Med Biol. 18:121-127, 2017.

OBJECTIVE: Acute mountain sickness (AMS) is defined by patient-reported symptoms using the Lake Louise Score (LLS), which provides limited insight into any possible underlying central nervous system (CNS) dysfunction. Some evidence suggests AMS might coexist with altered neural functioning. Cognitive impairment (CI) may go undetected unless a sensitive test is applied. Our hypothesis was that a standardized test for mild CI would provide an objective measure …

The Role Of Adenosine Signaling In Mature Erythrocytes And Erythroid Progenitors, Hong Liu

Dissertations & Theses (Open Access)

Adenosine is a ubiquitous nucleoside in almost all the cells throughout our bodies. It is highly induced particularly under hypoxia or energy depletion conditions. Adenosine functions as a critical ligand, after binding to membrane-associated adenosine receptors, adenosine initiates a downstream signaling cascade and subsequently contributes to functions of nervous system, immune response, vascular function and even metabolism.

Hypoxia is a condition with limited O₂ availability in the whole body or a region of the body. It is a major consequence of many respiratory and cardiovascular diseases, as well as for people living and working at high altitudes or other …

Effects Of Pre-Acclimatization Applying The ‘‘Climb High And Sleep Low’’ Maxim: An Example Of Rapid But Safe Ascent To Extreme Altitude, Martin Burtscher, Robert Koch

Journal of Human Performance in Extreme Environments

Pre-acclimatization at a convenient high-altitude location may represent an appropriate method before climbing a more hostile target mountain. The aim of the present field report was to demonstrate the effectiveness of such pre-acclimatizing applying the ‘‘climb high sleep low’’ maxim for a subsequent rapid ascent to almost 7000 m. After some pre-acclimatization in the Alps the authors flew to Chile for further pre-acclimatization in the Aymara village of Putre (3650 m). From there they undertook sojourns up to altitudes of 5700 m within 3 days. Subsequently they went back to Arica (sea level) and climbed Ojos del Salado (6893 m) …