Medicine and Health Sciences Commons^™

Spatiotemporally Dynamic Electric Fields For Brain Cancer Treatment: An In Vitro Investigation, Erin Iredale, Abdulla Elsaleh, Hu Xu, Paul Christiaans, Andrew Deweyert, John Ronald, Susanne Schmid, Matthew O Hebb, Terry M Peters, Eugene Wong

Anatomy and Cell Biology Publications

Objective. The treatment of glioblastoma (GBM) using low intensity electric fields (∼1 V cm^-1) is being investigated using multiple implanted bioelectrodes, which was termed intratumoral modulation therapy (IMT). Previous IMT studies theoretically optimized treatment parameters to maximize coverage with rotating fields, which required experimental investigation. In this study, we employed computer simulations to generate spatiotemporally dynamic electric fields, designed and purpose-built an IMT device for in vitro experiments, and evaluated the human GBM cellular responses to these fields. Approach. After measuring the electrical conductivity of the in vitro culturing medium, we designed experiments to evaluate the …

Perspectives Of Individuals With Chronic Spinal Cord Injury Following Novel Balance Training Involving Functional Electrical Stimulation With Visual Feedback: A Qualitative Exploratory Study, David J Houston, Janelle Unger, Jae W Lee, Kei Masani, Kristin E Musselman

Physical Therapy Publications

BACKGROUND: Individuals with an incomplete spinal cord injury (iSCI) are highly susceptible to falls during periods of walking or standing. We recently reported the findings of a novel intervention combining functional electrical stimulation with visual feedback balance training (FES + VFBT) on standing balance abilities among five individuals with motor iSCI. However, the previous publication did not report the perceived impact of the intervention on the participants' lives. In this report, the experiences of these five individuals with incomplete spinal cord injury (iSCI) who had recently completed the four-week balance training program are described.

METHODS: Five individuals with a motor …

Results Of The Adhere Upper Airway Stimulation Registry And Predictors Of Therapy Efficacy., Erica Thaler, Richard Schwab, Joachim Maurer, Ryan Soose, Christopher Larsen, Suzanne Stevens, Damien Stevens, Maurits Boon, Colin Huntley, Karl Doghramji, Tina Waters, Alan Kominsky, Armin Steffen, Eric Kezirian, Benedikt Hofauer, Ulrich Sommer, Kirk Withrow, Kingman Strohl, Clemens Heiser

Department of Psychiatry and Human Behavior Faculty Papers

OBJECTIVE/HYPOTHESIS: The ADHERE Registry is a multicenter prospective observational study following outcomes of upper airway stimulation (UAS) therapy in patients who have failed continuous positive airway pressure therapy for obstructive sleep apnea (OSA). The aim of this registry and purpose of this article were to examine the outcomes of patients receiving UAS for treatment of OSA.

STUDY DESIGN: Cohort Study.

METHODS: Demographic and sleep study data collection occurred at baseline, implantation visit, post-titration (6 months), and final visit (12 months). Patient and physician reported outcomes were also collected. Post hoc univariate and multivariate analysis was used to identify predictors of …

How To Implant A Phrenic Nerve Stimulator For Treatment Of Central Sleep Apnea?, Ralph S Augostini, Timothy W Smith, Et Al.

2010-2019 OA Pubs

BACKGROUND: Central sleep apnea (CSA) is a breathing disorder caused by the intermittent absence of central respiratory drive. Transvenous phrenic nerve stimulation is a new therapeutic option, recently approved by the FDA , for the treatment of CSA.

OBJECTIVE: To describe the technique used to implant the transvenous phrenic nerve stimulation system (the remedē System, Respicardia, Inc).

METHODS: The remedē System is placed in the pectoral region, typically on the right side. A single stimulation lead is placed in either the left pericardiophrenic vein (PPV) or the right brachiocephalic vein (RBC). A sensing lead is placed into the azygous vein …

White Matter Biomarkers Associated With Motor Change In Individuals With Stroke: A Continuous Theta Burst Stimulation Study, K P Wadden, Sue Peters, M R Borich, J L Neva, K S Hayward, C S Mang, N J Snow, K E Brown, T S Woodward, S K Meehan, L A Boyd

Physical Therapy Publications

Continuous theta burst stimulation (cTBS) is a form of noninvasive repetitive brain stimulation that, when delivered over the contralesional hemisphere, can influence the excitability of the ipsilesional hemisphere in individuals with stroke. cTBS applied prior to skilled motor practice interventions may augment motor learning; however, there is a high degree of variability in individual response to this intervention. The main objective of the present study was to assess white matter biomarkers of response to cTBS paired with skilled motor practice in individuals with chronic stroke. We tested the effects of stimulation of the contralesional hemisphere at the site of the …

The Use Of Neuromuscular Electrical Simulation In Glenohumeral Unidirectional Instability When An Exercise-Based Approach Has Failed: A Case Study, Kunal Bhanot, Navpreet Kaur, J Butler

Physical Therapy Collection

Purpose of this case study was to report the role of neuromuscular electrical stimulation (NMES) to restore strength and normal motion in a patient with unidirectional shoulder instability or glenohumeral internal rotation deficit (GIRD).

Fsm Restores Activity To Trapezius For 67 Y.O. Male, Marilyn Miller, Carolyn R. Mcmakin

San Marcos, Fall 2018

One session of frequency specific microcurrent (FSM) restored voluntary function and muscle definition for a 67 y. o. male DIY enthusiast after 18 mos of disuse.

Tumor-Treating Fields Plus Chemotherapy Versus Chemotherapy Alone For Glioblastoma At First Recurrence: A Post Hoc Analysis Of The Ef-14 Trial., Santosh Kesari, Zvi Ram

Articles, Abstracts, and Reports

BACKGROUND: This post hoc analysis of the EF-14 trial (NCT00916409) of tumor-treating fields (TTFields) plus temozolomide versus temozolomide alone in newly diagnosed glioblastoma compared the efficacy of TTFields plus chemotherapy (physician's choice) versus chemotherapy alone after first recurrence.

METHODS: Patients on TTFields plus temozolomide continued TTFields plus second-line chemotherapy after first recurrence. Some patients on temozolomide alone crossed over after approval of TTFields for recurrent GBM. The primary efficacy outcome was overall survival (OS).

RESULTS: After disease progression, 131 patients received TTFields plus chemotherapy and 73 chemotherapy alone. Thirteen patients in the original temozolomide-alone group crossed over to receive TTFields …

Low Back Pain: A Case Study, Samir Maleki

Physical Therapy Scholarly Projects

Background and Purpose: Low back pain (LBP) is a common complaint in the U.S., and has many possible causes. Multiple physical therapy interventions, including electrotherapy, traction, and lumbar stabilization exercises such as bridging and planking variations, have been shown to be very effective in reducing LBP. The purpose of this case study is to examine the effects of lumbar stabilization exercise and electrotherapy on LBP.

Case Description: The patient was a 43 year-old male, who had been experiencing LBP for the past year. He reported falling off of a truck and landing with his hand tucked into the …

Physical Modalities In Chronic Pain Management, Barbara Rakel, J. Barr

Barbara A. Rakel

The following conclusions can be made based on review of the evidence: There is limited but positive evidence that select physical modalities are effective in managing chronic pain associated with specific conditions experienced by adults and older individuals. Overall, studies have provided the most support for the modality of therapeutic exercise. Different physical modalities have similar magnitudes of effects on chronic pain. Therefore, selection of the most appropriate physical modality may depend on the desired functional outcome for the patient, the underlying impairment, and the patient's preference or prior experience with the modality. Certain patient characteristics may decrease the effectiveness …

Electrical Stimulation For Post-Cva Individuals, Jennifer Carlson

Occupational Therapy Capstones

No abstract provided.

The Use Of Functional Electrical Stimulation (Fes) To Produce Functional Movement In Individuals With Paraplegia, Melissa Jendro

Physical Therapy Scholarly Projects

Spinal cord injury (SCI) affects approximately 7600 to 11000 people per year, and alters every aspect of the individuals' lives. SCI primarily affects young Caucasian adults. The majority are between 16 to 30 years old, with the average age being 19. Motor vehicle accidents account for 35% to 40% of SCI cases reported, with violence in close second at 25%. Currently, the highest neurological category is of complete paraplegia followed by incomplete quadriplegia. SCIs often cause many complications due to decreased physical activity and changes in bodily functions.

Among treatment options, functional electrical stimulation (FES) is used to restore a …

Functional Electrical Stimulation As A Treatment For Spinal Cord Injuries, Gail Garrett

Physical Therapy Scholarly Projects

Injury of the spinal cord resulting in quadriplegia or paraplegia IS one of the most devastating conditions a person can experience. The majority of these individuals that suffer from a spinal cord injury are young males. The inability to ambulate is generally a major concern for these patients, but there are also degenerative and deconditioning effects of the spinal cord injury which may lead to devastating secondary complications that must be addressed.

Functional electrical stimulation (FES) has been the subject of much research concerning the rehabilitation for patients with spinal cord injury. Functional electrical stimulation is a way to activate …

The Use Of Lower Extremity Functional Electrical Stimulation In Spinal Cord Injured Patients, Michelle Mccrory

Physical Therapy Scholarly Projects

Spinal cord injury (SCI) is a devastating, life-altering injury that presents a variety of rehabilitative and long-term medical management challenges. Not only must the inability to ambulate, which is generally of primary concern to the patient, be addressed, but also the inherent degenerative and deconditioning effects of SCI which may ultimately lead to various secondary complications.

Recently, functional electrical stimulation (FES) has been the subject of a variety of research concerning the rehabilitation of individuals with SCI. FES is a means of activating alpha motor neurons to stimulate muscular contraction and elicit a therapeutic or functional effect.

The purpose of …

Electrical Stimulation As An Adjunct To Healing, Mary J. Lee

Physical Therapy Scholarly Projects

The purpose of this overview is to offer a possible avenue for advancing wound or ulcer healing when working with a population who experience complications of skin healing. In respect to their normal functional activities, these persons will experience limitations, and will also require more utilization of medical resources to assist in their progress. Dermal ulcers may predispose them to even further complications. There are many factors which influence the healing rate. Low voltage current and, more recently, the use of high voltage pulsed current, has been researched to serve as an additional treatment possibility for improved skin status.