Medicine and Health Sciences Commons^™

Improving Value In Colorectal Cancer Care: An Economic Analysis Of Enhanced Recovery Protocols At A Community Hospital, Lexi Frankel, Amalia D. Ardeljan, Ali Rashid, Abhishek Nair, Kazuaki Takabe, Omar M. Rashid

HPD Articles

Background: Enhanced recovery protocols (ERPs) have been shown to improve the outcomes of gastrointestinal cancer care, leading to reduced morbidity of gastrointestinal treatment and reduced delays in systemic therapy. ERP implementation has also previously shown a reduction in length of stay (LOS) without changing the readmission rate; however, the economic cost associated with these measures has not yet been quantified. The aim of this study was to evaluate the economic costs of ERP implementation for colorectal cancer at a community hospital. Methods: The Diagnostic Related Group (DRG) codes were used to assess costs associated with the hospitalizations of cases in …

The Effect Of Social Exclusion On Trust Among Youth Orphaned By Hiv/Aids: Evidence From An Event-Related Potentials Study, Jiaojiao Wan, Qi Zhao, Yafei Zhang, Lili Ji, Junfeng Zhao, Shan Qiao Ph.D., Xiaoming Li Ph.D.

Faculty Publications

Grounded in a follow-up study among children who lost one or both parents to HIV in central China in the early 2000s, we conducted an event-related potentials (ERPs) experiment to explore the effect of social exclusion on trust and the corresponding neurophysiological mechanism among youth orphaned by HIV/AIDS (“AIDS orphans”). A sample of 31 AIDS orphans (26.16 ± 3.34 years old; 15 female) and 32 age and development status matched controls (25.02 ± 3.45 years old; 14 female) participated in the study. They were all assigned to play Cyberball, a virtual ball-tossing game that reliably induced social exclusion (15 orphans, …

Attentional Influences On Neural Processing Of Biological Motion In Typically Developing Children And Those On The Autism Spectrum, Emily J. Knight, Aaron I. Krakowski, Edward G. Freedman, John Butler, Sophie Molholm, John J. Foxe

Articles

Biological motion imparts rich information related to the movement, actions, intentions and affective state of others, which can provide foundational support for various aspects of social cognition and behavior. Given that atypical social communication and cognition are hallmark symptoms of autism spectrum disorder (ASD), many have theorized that a potential source of this deficit may lie in dysfunctional neural mechanisms of biological motion processing. Synthesis of existing literature provides some support for biological motion processing deficits in autism spectrum disorder, although high study heterogeneity and inconsistent findings complicate interpretation. Here, we attempted to reconcile some of this residual controversy by …

Different Pathways To Cognition: An Erp Investigation Of Enhanced Perceptual Functioning And Autistic Traits In School-Aged Children, Elizabeth Anne Kaplan-Kahn

Dissertations - ALL

Autistic individuals show enhanced perceptual functioning on a range of behavioral tasks. Neurophysiological evidence, from both fMRI and event related potential (ERP) studies, also supports the conclusion that autistic individuals utilize perceptual processes to a greater extent than neurotypical comparisons to support problem solving and reasoning. Despite substantial evidence supporting differential information processing streams in autism, the relationship between these processing streams and autistic traits is not well understood. One study has investigated the relationships between autistic traits, early perceptual ERPs, and subsequent cognitive ERPs in neurotypical adults; however, these relationships have yet to be explored in autistic and neurotypical …

Neural Correlates Of The Dunning-Kruger Effect, Alana Muller, Lindsey A. Sirianni, Richard Addante

Psychology Faculty Publications

The Dunning-Kruger effect (DKE) is a metacognitive phenomenon of illusory superiority in which individuals who perform poorly on a task believe they performed better than others, yet individuals who performed very well believe they under-performed compared to others. This phenomenon has yet to be directly explored in episodic memory, nor explored for physiological correlates or reaction times. We designed a novel method to elicit the DKE via a test of item recognition while electroencephalography (EEG) was recorded. Throughout the task, participants were asked to estimate the percentile in which they performed compared to others. Results revealed participants in the bottom …

Nudging The N170 Forward With Prior Stimulation—Bridging The Gap Between N170 And Recognition Potential, Canhuang Luo, Wei Chen, Rufin Vanrullen, Ye Zhang, Carl Michael Gaspar

All Works

Evoked response potentials are often divided up into numerous components, each with their own body of literature. But is there less variety than we might suppose? In this study, we nudge one component into looking like another. Both the N170 and recognition potential (RP) are N1 components in response to familiar objects. However, the RP is often measured with a forward mask that ends at stimulus onset whereas the N170 is often measured with no masking at all. This study investigates how inter-stimulus interval (ISI) may delay and distort the N170 into an RP by manipulating the temporal gap (ISI) …

Network-Level Mechanisms Underlying Effects Of Transcranial Direct Current Stimulation (Tdcs) On Visuomotor Learning, Pejman Sehatpour, Clément Dondé, Matthew J. Hoptman, Johanna Kreither, Devin Adair, Elisa Dias, Blair Vail, Stephanie Rohrig, Gail Silipo, Javier Lopez-Calderon, Antigona Martinez, Daniel C. Javitt

Publications and Research

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation approach in which low level currents are administered over the scalp to influence underlying brain function. Prevailing theories of tDCS focus on modulation of excitation-inhibition balance at the local stimulation location. However, network level effects are reported as well, and appear to depend upon differential underlying mechanisms. Here, we evaluated potential network-level effects of tDCS during the Serial Reaction Time Task (SRTT) using convergent EEG- and fMRI-based connectivity approaches. Motor learning manifested as a significant (p <.0001) shift from slow to fast responses and corresponded to a significant increase in beta-coherence (p <.0001) and fMRI connectivity (p <.01) particularly within the visual-motor pathway. Differential patterns of tDCS effect were observed within different parametric task versions, consistent with network models. Overall, these findings demonstrate objective physiological effects of tDCS at the network level that result in effective behavioral modulation when tDCS parameters are matched to network-level requirements of the underlying task.

Multimodal Computational Modeling Of Visual Object Recognition Deficits But Intact Repetition Priming In Schizophrenia, Pejman Sehatpour, Anahita Bassir Nia, Devin Adair, Zhishun Wang, Heloise M. Debaun, Gail Silipo, Antigona Martinez, Daniel C. Javitt

Publications and Research

The term perceptual closure refers to the neural processes responsible for “filling-in” missing information in the visual image under highly adverse viewing conditions such as fog or camouflage. Here we used a closure task that required the participants to identify barely recognizable fragmented line-drawings of common objects. Patients with schizophrenia have been shown to perform poorly on this task. Following priming, controls and importantly patients can complete the line-drawings at greater levels of fragmentation behaviorally, suggesting an improvement in their ability to performthe task. Closure phenomena have been shown to involve a distributed network of cortical regions, notably the lateral …

Digital Technologies As Antecedents To Process Integration And Dynamic Capabilities In Healthcare: An Empirical Investigation, Tulika Chakravorty, Karunakar Jha, Sunil Barthwal, Samyadip Chakraborty

Journal of International Technology and Information Management

Healthcare has been in focus over the past decade due to its criticality and continuous revolution. In this digital era, with the advent of various technologies, healthcare is undergoing a massive transformation. This study attempts to analyze the impacts of three major digital technologies which are being adopted in the healthcare sector which are electronic medical records (EMR), enterprise resource planning (ERP) and internet-of-things (IoT) enabled medical wearables in the hospital context. Focusing towards analyzing the impact of these technologies towards process-integration and further towards dynamic capabilities like quality, agility and responsiveness; the study framework is well-grounded by two theoretical-underpinnings …

What Makes An Image Memorable? Effects Of Encoding On The Mechanism Of Recognition, Asiya Gul

Theses and Dissertations (Comprehensive)

Memory is undoubtedly one of the most important processes of human cognition. A long line of research suggests that recognition relies on the assessment of two explicit memory phenomena: familiarity and recollection. Researchers who support the Dual Process Signal Detection (DPSD) model of recognition memory link the FN400 component (a negative ERP deflection peaking around 400 ms at frontal electrodes) with familiarity; however, it is currently unclear whether the FN400 reflects familiarity or implicit memory. Three event-related potentials (ERP) studies were conducted to determine whether implicit memory plays a role in setting up encoding strategies, and how these encoding strategies …

Neuro-Correlates Of Word Processing Among Four-And-Five-Year-Old Children From Homes Varying In Socio-Economic Status, Wendy Olsen

USF Tampa Graduate Theses and Dissertations

A large body of research relates families’ socioeconomic status (SES) to child language development (Hoff & Tian, 2005). Results from these studies indicate preschoolers from low SES backgrounds may have underdeveloped linguistic foundations required for future academic success (Sirin, 2005; Lacouri & Tissington, 2011). These differences have been said to create a 30 million word-gap between the language experiences of low and middle to high SES children by the age of 3 years. Thus, children who come from lower SES backgrounds often lack the vocabulary knowledge used in school and in textbooks (Hart & Risley, 1995). One index of SES …

Implementing An Enhanced Recovery After Surgery Protocol In A Critical Access Hospital, Joseph Grazaitis

Doctor of Nursing Practice Projects

Enhanced recovery after surgery (ERAS) protocols provide numerous benefits for patients undergoing colorectal surgery. The goal of the protocol is to decrease surgical complications, patient’s length of hospital stay, recovery time, and increase patient satisfaction. The purpose of this doctoral project was to create and implement an ERAS protocol for a 25-bed critical access hospital. The findings obtained from the literature review were presented to the multi-disciplinary team. The specific needs of the surgical team were identified, and the ERAS protocol was created. Lastly, the ERAS protocol was finalized and implemented in the institution. The outcome measures examined were the …

Working Memory And Falls Risk In Older Adults: An Event-Related Potential Study, Yee (Michelle) S. Wong

Electronic Thesis and Dissertation Repository

BACKGROUND: The aging population is rapidly increasing, where currently in North America, the population of older adults (ages 60+) outnumbers the population of children. Falls are a major concern for older adults and their quality of life. Cognitive impairment has been shown to be declined in older adults at-risk for falls, but working memory has not been thoroughly investigated within this population. PURPOSE: To examine differences in Non-Fallers, Moderate Risk for Falls, and Fallers in a working memory task using electroencephalography (EEG). METHODS: Older adults (n=44, female=27) aged 60 – 80 years (m=68.8, SD=4.7) completed two sessions. The first session …

The Influence Of Induced Anxiety On The P3 Event Related Brain Potentials Of Athletes And Novices In A Go/Nogo Task, Conley Waters, Keri Weed

Journal of the South Carolina Academy of Science

An elite athlete employs complex skills during competition that have been learned and perfected over long periods of training. Skills that include kicking, throwing, and hitting are complicated and require heightened motor control, focus, and attention. Attention allocation and motor control may be evaluated by the P3 wave, a neurophysiological measure of cognitive control. The Go/NoGo task is often used to elicit a P3 wave by averaging electroencephalogram readings from frequent stimuli that require a response (Go) and infrequent stimuli that require response inhibition (NoGo). Anxiety may also affect performance, both on the athletic field and in the research laboratory. …

Neural And Behavioral Mechanisms Of Clear Speech, Jenna Silver Luque

USF Tampa Graduate Theses and Dissertations

Clear speech is a speaking style that has been shown to improve intelligibility in adverse listening conditions, for various listener and talker populations. Clear-speech phonetic enhancements include a slowed speech rate, expanded vowel space, and expanded pitch range. Although clear-speech phonetic enhancements have been demonstrated across a variety of talkers, only a subset of these changes may be required for listeners to benefit perceptually from clear speech. Furthermore, while current literature has provided some understanding of the phonetic enhancements that are typical of clear speech and the improvements in intelligibility resulting from its use, less is understood regarding how listeners …

Is Allocation Of Attention Impaired In Fallers Compared To Non-Fallers? An Event-Related Potential Study, Phil Parrot-Migas

Electronic Thesis and Dissertation Repository

Approximately 30% of older adults experience one or more falls annually. The ability to properly allocate attention may be a risk factor falls. Our study examined whether older adults (aged 58-79) with a history of falls, allocated attention differently to auditory distractor stimuli compared to those without a history of falls, and whether such differences subsequently altered cognitive processing of visual target stimuli. We examined allocation of attention using event-related potentials (ERPs) as participants responded to visual targets while ignoring task-irrelevant auditory distractors. A posterior to anterior shift in electrical brain activity was exaggerated in the faller group compared to …

Tuning Up The Old Brain With New Tricks: Attention Training Via Neurofeedback, Yang Jiang, Reza Abiri, Xiaopeng Zhao

Sanders-Brown Center on Aging Faculty Publications

Neurofeedback (NF) is a form of biofeedback that uses real-time (RT) modulation of brain activity to enhance brain function and behavioral performance. Recent advances in Brain-Computer Interfaces (BCI) and cognitive training (CT) have provided new tools and evidence that NF improves cognitive functions, such as attention and working memory (WM), beyond what is provided by traditional CT. More published studies have demonstrated the efficacy of NF, particularly for treating attention deficit hyperactivity disorder (ADHD) in children. In contrast, there have been fewer studies done in older adults with or without cognitive impairment, with some notable exceptions. The focus of this …

Auditory Erp Differences Across A Continuum Of Psychotic Symptoms In Non-Clinical Population, Anaya Rehman

Theses and Dissertations (Comprehensive)

Psychosis is a term given to a mental state described as a loss of contact with the real world. The aim of this thesis was to examine early non-specific psychotic experiences in a healthy population by means of two self-report screening tools: Prime Screen and Youth Psychosis At-Risk Questionnaire-Brief, and place individuals on a psychosis continuum. Across this psychosis continuum, three event related potential (ERP) components were assessed: P300, Mismatch Negativity and N100. There is evidence that P300 and mismatch negativity amplitudes diminish in individuals with psychosis. Similarly, impaired N100 amplitude suppression (increased N100 amplitudes) during vocalization has been observed …

Event Related Potentials In A Two Stimuli Auditory Oddball Task In Concussed College Athletes: A Linguistic Component Replication Study, Christopher Anthony Roosmalen

Open Access Theses & Dissertations

Concussions affect an estimated 1.6 to 3.8 million individuals annually and can result in persistent symptoms and cognitive impairments in attention and memory. Concussions are a rising health concern especially in concussion management. Event Related Potentials (ERP) may more accurately assess cognitive recovery making better return to play decisions. In 2013, Sanchez found no significant difference between concussed athletes and non-concussed individuals in the in amplitude of the P300 ERP component using an auditory oddball task consisting of 2 different consonant, vowel (CV) syllables. Because participants were instructed to maintain a mental and verbal count of the target stimuli, a …

Processing Of Language Switches In Bilingual Individuals With Aphasia: An Event-Related Potential Comparison, Lizette Rodarte

Open Access Theses & Dissertations

Switching between languages, or code-switching, is a common phenomenon in bilingual individuals. In proficient bilinguals, these switches are done with ease and are used for many purposes. Contrary to popular belief, these switches are rule-governed and follow grammatical structure. Bilingual individuals diagnosed with aphasia present with difficulty processing languages and these language switches. With the increase in bilingual individuals, it is likely that the speech-language pathology community will see an increase of bilingual individuals with aphasia on their caseload. For this reason, the purpose of this study is to increase our understanding of the neural processes involved in processing of …

Comparing Electrophysiologic Differences In Linguistic And Tonal Auditory Oddball Tasks In A Normal Population, Luisa Alejandra Esquivel

Open Access Theses & Dissertations

Limited studies using Event Related Potentials (ERP) comparing attentional differences between individuals with and without brain damage have been conducted. In addition, the literature review showed limited studies examining electrophysiologic performances that compare linguistic and tonal auditory oddball tasks. The purpose of this study is to examine the electrophysicologic differences between a linguistic and tonal oddball task in a group of participants with no brain damage. Event related potentials (ERP) were used to examine the neural processes of attention by measuring peak latency and amplitude of the P300 ERP component. Traditional auditory oddball tasks involve participants discriminating between two tones, …

Empirical Models Of Scalp-Eeg Responses Using Non-Concurrent Intracranial Responses, Komalpreet Kaur, Jerry J. Shih, Dean J. Krusienski

Electrical & Computer Engineering Faculty Publications

Objective- This study presents inter-subject models of scalp-recorded electroencephalographic (sEEG) event-related potentials (ERPs) using intracranially recorded ERPs from electrocorticography and stereotactic depth electrodes in the hippocampus, generally termed as intracranial EEG (iEEG).

Approach- The participants were six patients with medically-intractable epilepsy that underwent temporary placement of intracranial electrode arrays to localize seizure foci. Participants performed one experimental session using a brain-computer interface matrix spelling paradigm controlled by sEEG prior to the iEEG electrode implantation, and one or more identical sessions controlled by iEEG after implantation. All participants were able to achieve excellent spelling accuracy using sEEG, four of the participants …

Combined Erp/Fmri Evidence For Early Word Recognition Effects In The Posterior Inferior Temporal Gyrus, Joseph Dien, Eric S. Brian, Dennis L. Molfese, Brian T. Gold

Center for Brain, Biology, and Behavior: Faculty and Staff Publications

Two brain regions with established roles in reading are the posterior middle temporal gyrus and the posterior fusiform gyrus. Lesion studies have also suggested that the region located between them, the posterior inferior temporal gyrus (pITG), plays a central role in word recognition. However, these lesion results could reflect disconnection effects since neuroimaging studies have not reported consistent lexicality effects in pITG. Here we tested whether these reported pITG lesion effects are due to disconnection effects or not using parallel ERP/fMRI studies. We predicted that the Recognition Potential (RP), a left-lateralized ERP negativity that peaks at about 200–250 ms, might …

Event Related Potential Changes In A Two-Stimulus Auditory Oddball Task In Concussed College Athletes: A Linguistic Component, Paola G. Sanchez

Open Access Theses & Dissertations

"Return to Play" decisions are done based on cognitive-communicative testing and clinical assessments; concussed athletes may benefit from electrophysiological testing for a more accurate representation of their recovery. The purpose of this study is to investigate the electrophysiological performance post-concussion analyzing the attentional differences using the traditional "oddball" paradigm with a CV linguistic component. Participants for this study were 6 male college athletes with a history of concussion and 10 participants with no history of concussion (controls). Athletes were evaluated using event-related potentials (ERPs) that were recorded during a consonant-vowel (CV) auditory oddball task. Both the P300a and P300b components …

P900: A Putative Novel Erp Component That Indexes Counter-Measure Use In The P300-Based Concealed Information Test, John B. Meixner Jr., Elena Labkovsky, J. Peter Rosenfeld, Michael R. Winograd, Michael Winograd, Alexander Sokolovsky, Jeff Weishaar, Tim Ullmann

Scholarly Works

Countermeasures pose a serious threat to the effectiveness of the Concealed Information Test (CIT). In a CIT experiment, Rosenfeld and Labkovsky in Psychophysiology 47(6):1002–1010, (2010) observed a previously unknown positive ERP component at about 900 ms poststimulus at Fz and Cz that could potentially serve as an index of countermeasure use. Here, we explored the hypothesis that this component, termed P900, occurs in response to a signal that no further specific response is required in a trial, and could thus appear in countermeasure users that respond differentially depending on the stimulus that appears. In the present experiments, subjects viewed four …

A One-Hour Sleep Restriction Impacts Brain Processing In Young Children Across Tasks: Evidence From Event-Related Potentials, Dennis Molfese, Anna Ivanenko, Alexandra P.F. Key, Adrienne Roman, Victoria J. Molfese, Louise M. O'Brien, David Gozal, Srinivas Kota, Caitlin M. Hudac

Center for Brain, Biology, and Behavior: Faculty and Staff Publications

The effect of mild sleep restriction on cognitive functioning in young children is unclear, yet sleep loss may impact children's abilities to attend to tasks with high processing demands. In a preliminary investigation, six children (6.6 - 8.3 years of age) with normal sleep patterns performed three tasks: attention (“Oddball”), speech perception (conconant-vowel syllables) and executive function (Directional Stroop). Event-related potentials (ERP) responses were recorded before (Control) and following one-week of 1-hour per day of sleep restriction. Brain activity across all tasks following Sleep Restriction differed from activity during Control Sleep, indicating that minor sleep restriction impacts children's neurocognitive functioning.

Gradients And Ranges Of Visually Selective Attention Based On Location, Objects, Color, And Size: Gradients Are Universal, But Range Is Uniquely Spatial, William S. Bush

Open Access Dissertations

Two interesting properties of the distribution of spatially selective attention have been noted in the behavioral and electrophysiological literature. First, there is a graded field of attention that expands from the center of the attended area. Second, the size of the attended area can be adjusted to be either larger or smaller in order to match the demands of the current task. Five event-related potential (ERP) studies are presented that extend these findings in several important ways; 1) The time frame of these two distribution properties is different. Results are consistent with a two stage model of spatial attention in …

Assessing Cortical Electrophysiologic And Behavioral Activity In Individuals With Aphasia And Participants With No Brain Damage Responding To Spoken Sentence Length Messages, Patricia Lara

Open Access Theses & Dissertations

In this study, six individuals with aphasia and twelve participants with no brain damage responded to spoken sentence length messages using a modified version of the Revised Token Test (McNeil & Prescott, 1978) while cortical activation was recorded using event related potentials (ERP). ERP is a non-invasive imaging procedure that measures cortical activation reflected in the electrical activity that is produced at the level of the cortex in response to internal or external stimulus.

Participants were presented with a visual display that provided eight different token arrangements per trial that were displayed on the computer screen. Spoken messages that increased …

Changing The Rules At The Drop Of A Hat: An Erp Study Of Preschoolers' Set-Shifting Ability, Sandra A. Wiebe, Daniel J. Carroll, Megan Herrington, Sari Raber, Kimberly A. Espy

Developmental Cognitive Neuroscience Laboratory: Faculty and Staff Publications

We examined the neural correlates of set-shifting in 5-year-old children and examined whether the ease of switching was affected by varying the number of non-switch trials preceding a switch.

Smoking During Pregnancy Affects Speech-Processing Ability In Newborn Infants, Alexandra P.F. Key, Melissa Ferguson, Dennis L. Molfese, Kelley Peach, Victoria J. Molfese

Center for Brain, Biology, and Behavior: Faculty and Staff Publications

BACKGROUND: Tobacco smoking during pregnancy is known to adversely affect development of the central nervous system in babies of smoking mothers by restricting utero–placental blood flow and the amount of oxygen available to the fetus. Behavioral data associate maternal smoking with lower verbal scores and poorer performance on specific language/auditory tests.

OBJECTIVES: In the current study we examined the effects of maternal smoking during pregnancy on newborns’ speech processing ability as measured by event-related potentials (ERPs).

METHOD: High-density ERPs were recorded within 48 hr of birth in healthy newborn infants of smoking (n = 8) and nonsmoking …