Medicine and Health Sciences Commons^™

Air Pollution & The Brain: Subchronic Diesel Exhaust Exposure Causes Neuroinflammation And Elevates Early Markers Of Neurodegenerative Disease, Shannon Levesque, Michael J. Surace, Jacob Mcdonald, Michelle L. Block

Anatomy and Neurobiology Publications

Background

Increasing evidence links diverse forms of air pollution to neuroinflammation and neuropathology in both human and animal models, but the effects of long-term exposures are poorly understood.

Objective

We explored the central nervous system consequences of subchronic exposure to diesel exhaust (DE) and addressed the minimum levels necessary to elicit neuroinflammation and markers of early neuropathology.

Methods

Male Fischer 344 rats were exposed to DE (992, 311, 100, 35 and 0 μg PM/m³) by inhalation over 6 months.

Results

DE exposure resulted in elevated levels of TNFα at high concentrations in all regions tested, with the exception …

Integration Of Analysis And Deliberation To Evaluate Biodiesel Occupational And Environmental Exposures, Nora M. Traviss

Antioch University Full-Text Dissertations & Theses

Many U.S. organizations interested in a renewable and domestic source of energy are considering switching from petroleum diesel to biodiesel blends for transportation and heavy-duty equipment use. Biodiesel is a fuel made from vegetable oils or waste grease. While there is a considerable body of evidence on the negative health effects of petroleum diesel exhaust exposures in occupational and urban settings, there has been little research examining the impact of biodiesel fuel on occupational and environmental exposures. This dissertation combined a collaborative exposure assessment of B20 (20% soy-based biodiesel/80% diesel) at a rural recycling center with a policy intervention to …

How Exposure To Environmental Tobacco Smoke, Outdoor Air Pollutants, And Increased Pollen Burdens Influence The Incidence Of Asthma, M I. Gilmour, M S. Jaakola, S J. London, A Nel, Christine A. Rogers

Christine A. Rogers

Asthma is a multifactorial airway disease that arises from a relatively common genetic background interphased with exposures to allergens and airborne irritants. The rapid rise in asthma over the past three decades in Western societies has been attributed to numerous diverse factors, including increased awareness of the disease, altered lifestyle and activity patterns, and ill-defined changes in environmental exposures. It is well accepted that persons with asthma are more sensitive than persons without asthma to air pollutants such as cigarette smoke, traffic emissions, and photochemical smog components. It has also been demonstrated that exposure to a mix of allergens and …