Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 24 of 24
Full-Text Articles in Medicine and Health Sciences
Low Handgrip Strength Is Associated With Diabetic Foot Disease In Geriatric Patients With Type 2 Diabetes, Eren İmre, Neşe Koçakgöl, Erdi̇ İmre
Low Handgrip Strength Is Associated With Diabetic Foot Disease In Geriatric Patients With Type 2 Diabetes, Eren İmre, Neşe Koçakgöl, Erdi̇ İmre
Turkish Journal of Medical Sciences
Background/aim: This study aims to reveal the prevalence of low handgrip strength in older patients with type 2 diabetes who have diabetic foot disease and to assess the association of handgrip strength with diabetic foot disease in older patients with type 2 diabetes. Materials and methods: Eighty-nine geriatric patients with diabetic foot ulcers and 69 patients without diabetic foot ulcers who presented to the endocrinology outpatient clinic between August 2020 and November 2021 were included in the study. The exclusion criteria were the usage of steroids, stroke-induced quadriplegia, myopathy, disability, hemodialysis treatment, type 1 diabetes, patients under 65 years of …
Risk Factors Predicting The Development Of Diabetes Mellitus And Metabolic Syndromefollowing Gestational Diabetes Mellitus, Bülent Can, Sema Çi̇ftçi̇, Gülşah Yeni̇dünya Yalin, Nevi̇n Di̇nççağ
Risk Factors Predicting The Development Of Diabetes Mellitus And Metabolic Syndromefollowing Gestational Diabetes Mellitus, Bülent Can, Sema Çi̇ftçi̇, Gülşah Yeni̇dünya Yalin, Nevi̇n Di̇nççağ
Turkish Journal of Medical Sciences
Background/aim: To determine risk factors associated with the development of insulin resistance, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MetS) in gestational diabetes mellitus (GDM) patients 10 years after giving birth. Materials and methods: Medical records of patients with former GDM were screened. Eligible patients were invited to the hospital to obtain information about their present health status. Patients with pregestational diabetes and patients with multiple pregnancies were excluded. A total of 67 women formed the study group. American Diabetes Association (ADA) and International Diabetes Federation (IDF) criteria were used to define T2DM and MetS, respectively. Results: A total …
The Effect Of Caffeic Acid Phenethyl Ester And Ankaferd Blood Stopper On The Diabetic Andnondiabetic Gingival Wound Healing: An Experimental Study, Mehmet Gül, Serkan Dündar, Gökhan Artaş, Akin Yi̇ği̇n, Abdulsamet Tanik, Mehmet Emrah Polat, Erhan Cahi̇t Özcan
The Effect Of Caffeic Acid Phenethyl Ester And Ankaferd Blood Stopper On The Diabetic Andnondiabetic Gingival Wound Healing: An Experimental Study, Mehmet Gül, Serkan Dündar, Gökhan Artaş, Akin Yi̇ği̇n, Abdulsamet Tanik, Mehmet Emrah Polat, Erhan Cahi̇t Özcan
Turkish Journal of Medical Sciences
Background/aim: Healthy wound healing is very important for patient comfort. Diabetes is one of the factors that negatively affect wound healing. Ankaferd Blood Stopper (ABS) and caffeic acid phenethyl ester (CAPE) are antiinflammatory and antimicrobial agents and may have positive effects on wound healing. Materials and methods: In this study, 72 male Wistar albino rats were used. Rats; control, CAPE, ABS, diabetes + control, diabetes + ABS and diabetes + CAPE groups were divided into 6 groups. A healthy 36 rats created diabetes using streptozotocin (STZ). A gingival wound was created using a 4-mm punch biopsy in the gingival tissue …
An Immunohistochemical Examination Of Cinnamon Extract Administration Ondistribution Of Ngf (Nerve Growth Factor) And Trk-A (Tyrosine Kinase-A) Receptor Fordiabetic Rats With Pancreatic Tissue, Şükran Yedi̇el Aras, Ebru Karadağ Sari
An Immunohistochemical Examination Of Cinnamon Extract Administration Ondistribution Of Ngf (Nerve Growth Factor) And Trk-A (Tyrosine Kinase-A) Receptor Fordiabetic Rats With Pancreatic Tissue, Şükran Yedi̇el Aras, Ebru Karadağ Sari
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the administration of cinnamon extract that is known to be effective in decreasing the high blood glucose and the distribution of NGF and Trk-A receptor in pancreas with immunohistochemistry way. Materials and methods: The experimental groups were defined as control, sham, cinnamon, diabetes, and diabetes-cinnamon. At the end of the experiment, the pancreatic tissue samples were obtained for the rats. The hematoxylin-eosin and triple staining were used to examine histology. The immunohistochemical methods were performed on the sections of pancreatic tissue. In all groups, the body weight and fasting blood glucose …
Potential Antidiabetic Activity Of Benzimidazole Derivative Albendazole And Lansoprazoledrugs In Different Doses In Experimental Type 2 Diabetic Rats, Burak Di̇k, Devran Coşkun, Emre Bahçi̇van, Kami̇l Üney
Potential Antidiabetic Activity Of Benzimidazole Derivative Albendazole And Lansoprazoledrugs In Different Doses In Experimental Type 2 Diabetic Rats, Burak Di̇k, Devran Coşkun, Emre Bahçi̇van, Kami̇l Üney
Turkish Journal of Medical Sciences
Aim: The aim of this study is to determine the effects of different concentrations of albendazole and lansoprazole, which were benzimidazole derivatives, on endocrinologic and biochemical parameters in experimental type 2 diabetic (T2D) rats. Materials and methods: In this study, 46 male Wistar Albino rats were used. Animals were divided as healthy control (0.1 mL/rat/day saline, s.c, n = 6), diabetes control (0.1 mL/rat/day saline, s.c, n = 8), diabetes+low-dose albendazole (5 mg/kg, oral, n = 8), diabetes+highdose albendazole (10 mg/kg, oral n = 8), diabetes+low-dose lansoprazole (15 mg/kg, subcutaneous, n = 8), and diabetes+high-dose lansoprazole (30 mg/kg, subcutaneous, n …
Hand Infection In Patients With Diabetes: A Series Of 17 Cases And A Pooled Analysis Of The Literature, Anil Murat Öztürk, Serhat Uysal, Ilgin Yildirim Şi̇mşi̇r, Hi̇lmi̇ Güngör, Meltem Taşbakan
Hand Infection In Patients With Diabetes: A Series Of 17 Cases And A Pooled Analysis Of The Literature, Anil Murat Öztürk, Serhat Uysal, Ilgin Yildirim Şi̇mşi̇r, Hi̇lmi̇ Güngör, Meltem Taşbakan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to report the clinical characteristics and the treatment outcomes of hand infections in diabetic patients and to review the literature. Materials and methods: The medical records of 17 patients with diabetic hand infections admitted to the Diabetic Foot Care Center of two di erent clinics from January 2012 to October 2017 were reviewed. To perform the pooled analysis, published series (32 studies) were searched in two international databases (www.scopus.com and www.pubmed.com). Results: Of the 17 patients (mean age 61.7 ± 8.5 years), 8 (47.1%) were female. All cases were type 2 diabetes mellitus. …
Exploring The Role Of Mirnas In The Diagnosis Of Mody3, Oğuzhan Fati̇h Baltaci, Şeyma Çolakoğlu, Gökçe Güllü Amuran, Nesli̇han Aydin, Mehmet Sarğin, Arzu Karabay Korkmaz, Mehmet Temel Yilmaz, Ergül Berber
Exploring The Role Of Mirnas In The Diagnosis Of Mody3, Oğuzhan Fati̇h Baltaci, Şeyma Çolakoğlu, Gökçe Güllü Amuran, Nesli̇han Aydin, Mehmet Sarğin, Arzu Karabay Korkmaz, Mehmet Temel Yilmaz, Ergül Berber
Turkish Journal of Medical Sciences
Background/aim: MODY3 associated with HNF1A is the most common form of MODY and is clinically misdiagnosed as type 1 diabetes due to similar clinical symptoms. This study aimed to analyze the role of HNF1A-regulated miRNAs as a biomarker in the diagnosis of MODY3. Materials and methods: MIN6 cells were transfected with the HNF1A cDNA expression vector for overexpression or with siRNA specific to HNF1A to silence its expression. The HNF1A-regulated miRNAs were determined by RNA-Seq of the total RNA extract. Expressions of the candidate miRNAs in blood samples of MODY3, type 1 diabetes, and type 2 diabetes patients and in …
Impact Of Type 2 Diabetes Mellitus On Quality Of Life In People With Diabetespresenting To A Specialist Diabetes Clinic, Bilal Bin Younis, Rozina Arshad, Haroon Yousuf, Fatima Salman, Junaid Masood, Saima Khurshid
Impact Of Type 2 Diabetes Mellitus On Quality Of Life In People With Diabetespresenting To A Specialist Diabetes Clinic, Bilal Bin Younis, Rozina Arshad, Haroon Yousuf, Fatima Salman, Junaid Masood, Saima Khurshid
Turkish Journal of Medical Sciences
Background/aim: Quality of life is an important health-related factor that has an impact on all health interventions. The aim of the study was to assess psychosocial outcomes in people with diabetes Materials and methods: A total of 142 people with type 2 diabetes were recruited from a specialist diabetes center. The validated Urdu version of the WHO-5 Well-Being Index was administered for easy understanding of the quality of life of the regional population. Results: The 142 adult participants with diabetes were recruited from a specialist diabetes clinic. The rate of likely depression (WHO-5 score of <28) was 16.9%. Neuropathy was found to have a negative impact on the quality of life in people with diabetes (P 6lt; 0.001). Conclusion: People with complications of diabetes like neuropathy may experience worsening quality of life. It is advised to incorporate the WHO-5 into annual patient reviews as a measure of emotional well-being to drive changes that improve outcomes for people with diabetes.
Relation Of Unsupported And Unsupervised Exercise With Anthropometric And Biochemical Indices Among Type 2 Diabetic Patients, Prince Chikwere, Kwabena Nsiah, Marina Tandoh
Relation Of Unsupported And Unsupervised Exercise With Anthropometric And Biochemical Indices Among Type 2 Diabetic Patients, Prince Chikwere, Kwabena Nsiah, Marina Tandoh
Turkish Journal of Medical Sciences
Background/aim: Type 2 diabetes is a lifestyle-related condition. Lifestyle modification in the management of type 2 diabetes incorporates exercise. The aim of this study was to find out how unsupported and unsupervised exercise relates to anthropometric indices and biochemical indices in type 2 diabetes patients. Materials and methods: In the cross-sectional study, a structured questionnaire was used to access data on the exercise history of patients. Subjects were classified according to exercise intensity. The dietary intake of patients was obtained by 24-h recall. Standard measurements were taken of waist circumference and blood pressure. Blood samples were also collected to measure …
Effects Of A Self-Management Educational Program On Metabolic Control In Type 2 Diabetes, Hosein Ali Sadeghian, Sri Venkata Madu, Kamal Agrawal, Aanjor Tupil Kannan, Kireet Agrawal
Effects Of A Self-Management Educational Program On Metabolic Control In Type 2 Diabetes, Hosein Ali Sadeghian, Sri Venkata Madu, Kamal Agrawal, Aanjor Tupil Kannan, Kireet Agrawal
Turkish Journal of Medical Sciences
Background/aim: India has 63 million diabetic people and the overall prevalence of diabetes in this country is 8.37%. Lifestyle modification by education is the most cost-effective strategy to have better metabolic control. The aim of this study was to investigate the effects of a self-management educational program on control of type 2 diabetes Materials and methods: It was a randomized controlled interventional study conducted among 306 patients with type 2 diabetes mellitus attending the Diabetic Clinic at G.T.B. Hospital, Delhi, from March 2010 to May 2013. The intervention was in the form of group education based on a self-management program, …
Effects Of Crocin On Experimental Obesity And Type-2 Diabetes, Ömer Hazman, Laçi̇ne Aksoy, Ahmet Büyükben
Effects Of Crocin On Experimental Obesity And Type-2 Diabetes, Ömer Hazman, Laçi̇ne Aksoy, Ahmet Büyükben
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to scrutinize the effects of crocin on obesity and type-2 diabetes, with an approach that takes oxidative stress and inflammatory parameters into account. Materials and methods: The experimental obesity model was created by utilizing a 10-week-long high-fat diet (HFD). An experimental type-2 diabetes model was created by injecting multiple low-dose streptozocin (STZ) injections into rats that were fed with the HFD. The treatment groups were administered a daily crocin dose of 150 mg/kg for 6 weeks via gavage. Results: Findings of the study demonstrated that crocin could be effective in relieving the symptoms …
Analysis Of Diabetes-Related Cerebellar Changes In Streptozotocin-Induced Diabetic Rats, Nuri̇ye Güzi̇n Özdemi̇r, Feray Akbaş, Tuğba Koti̇l, Adem Yilmaz
Analysis Of Diabetes-Related Cerebellar Changes In Streptozotocin-Induced Diabetic Rats, Nuri̇ye Güzi̇n Özdemi̇r, Feray Akbaş, Tuğba Koti̇l, Adem Yilmaz
Turkish Journal of Medical Sciences
Background/aim: Diabetic peripheral neuropathy has been extensively studied and reported, but the number of studies that have investigated diabetes-related changes in the central nervous system are limited, with even fewer studies on the cerebellum. The aim of this experimental study was to perform a histologic analysis of the diabetes-related changes in the cerebellums of diabetic rats. Materials and methods: Twenty Sprague Dawley rats weighing between 200 and 220 g were included in the study. Diabetes was induced in 14 of these rats by a single intraperitoneal injection of 65 mg/kg streptozotocin dissolved in saline, while 6 animals constituted the control …
Protective Effects Of Royal Jelly Against Testicular Damage In Streptozotocin-Induced Diabetic Rats, Turan Karaca, Seli̇m Demi̇rtaş, İhsan Karaboğa, Süleyman Ayvaz
Protective Effects Of Royal Jelly Against Testicular Damage In Streptozotocin-Induced Diabetic Rats, Turan Karaca, Seli̇m Demi̇rtaş, İhsan Karaboğa, Süleyman Ayvaz
Turkish Journal of Medical Sciences
To examine the effects of royal jelly (RJ) on testicular damage in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Eighteen adult Wistar albino rats were used, 6 in each of the 3 treatment groups: Group A: control, Group B: STZ-induced diabetes (untreated), Group C: STZ-induced diabetes plus RJ (400 mg/kg daily for 4 weeks). Diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg). Four weeks after the onset of diabetes, testicular apoptotic cell death was examined using immunohistochemical staining for caspase-3 and Ki67 staining for localization of proliferative cells. Results: Compared with the control, the body and …
Herbal Self-Medication Use In Patients With Diabetes Mellitus Type 2, Ivana Damnjanovic, Dusanka Kitic, Nikola Stefanovic, Snezana Zlatkovic-Guberinic, Aleksandra Catic-Djordjevic, Radmila Velickovic-Radovanovic
Herbal Self-Medication Use In Patients With Diabetes Mellitus Type 2, Ivana Damnjanovic, Dusanka Kitic, Nikola Stefanovic, Snezana Zlatkovic-Guberinic, Aleksandra Catic-Djordjevic, Radmila Velickovic-Radovanovic
Turkish Journal of Medical Sciences
Background/aim: A considerable number of patients suffering from diabetes mellitus (DM) turn to self-medication using medicinal plants, preparations, and medicine. The aim of this study was to investigate self-medication using medicinal plants and the potential influence of health care professionals' advice or media information regarding the use of herbal dietary supplements with hypoglycemic effect in a population of patients with type 2 DM. Materials and methods: This research, in the form of an analytic cross-sectional study, was conducted in 6 pharmacies in the territory of Nis, Serbia, during October 2013. The criterion set for the study was to include patients …
Diabetes Prevalence And Awareness In Adults In The Balçova District In Turkey, Kevser Tari Selçuk, Meli̇h Kaan Sözmen, Belgi̇n Ünal Toğrul
Diabetes Prevalence And Awareness In Adults In The Balçova District In Turkey, Kevser Tari Selçuk, Meli̇h Kaan Sözmen, Belgi̇n Ünal Toğrul
Turkish Journal of Medical Sciences
Background/aim: To determine the prevalence and awareness of diabetes and to evaluate associated factors in a population aged 30 and over in the Balçova district of İzmir, Turkey. Materials and methods: In this cross-sectional study data from 12,915 people who participated in Balçova's Heart Project were evaluated. Diabetes was defined using fasting blood glucose levels according to ADA criteria. Results: Diabetes prevalence was 13.0% and 87.7% of the patients were aware of the condition. Diabetes prevalence was 1.32 times higher in males, 1.31 times higher in individuals with primary school or lower level of education, 1.37 times higher in individuals …
Effects Of Lycopene On Plasma Glucose, Insulin Levels, Oxidative Stress, And Body Weights Of Streptozotocin-Induced Diabetic Rats, Muhsi̇n Aydin, Sefa Çeli̇k
Effects Of Lycopene On Plasma Glucose, Insulin Levels, Oxidative Stress, And Body Weights Of Streptozotocin-Induced Diabetic Rats, Muhsi̇n Aydin, Sefa Çeli̇k
Turkish Journal of Medical Sciences
To determine possible therapeutic effects of oral lycopene supplementation on plasma insulin levels, lipid peroxidation, blood glucose levels, and the antioxidant defense system of streptozotocin-induced diabetic rats. Materials and methods: Classical biochemical methods were used to determine plasma malondialdehyde (MDA), nitric oxide (NO), glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels. Enzyme-linked immunosorbent assay was used to determine plasma insulin levels and reverse transcriptase-polymerase chain reaction was used to determine the levels of brain antioxidant enzymes (SOD, CAT, and GSH-Px). Results: It was found that the diabetes-related increase in blood glucose levels was reduced by supplementation …
Does Central Corneal Thickness Correlate With Haemoglobin A1c Level And Disease Severity In Diabetes Type Ii?, Mehmet Özgür Zengi̇n, Zeynep Özbek, Gül Arikan, İsmet Durak, Ali̇ Osman Saatci̇
Does Central Corneal Thickness Correlate With Haemoglobin A1c Level And Disease Severity In Diabetes Type Ii?, Mehmet Özgür Zengi̇n, Zeynep Özbek, Gül Arikan, İsmet Durak, Ali̇ Osman Saatci̇
Turkish Journal of Medical Sciences
To compare central corneal thickness (CCT) values of patients with type II diabetes mellitus with those of healthy subjects, and evaluate the effect of disease duration, retinopathy severity, and HbA1c level on CCT. Materials and methods: One hundred and twenty-six consecutive type II diabetic patients and 36 non-diabetic healthy subjects were included in the study. CCT was measured using the Orbscan II corneal topography system. The effect of disease duration, retinopathy severity, and HbA1c level on CCT was evaluated using analysis of variance (ANOVA) and the independent sample t test. Results: CCT was significantly higher in diabetic patients than in …
Digito-Palmar Complex In Non-Insulin Dependent Diabetes Mellitus, Vadgaonkar Rajanigandha, Pai Mangala, Prabhu Latha, Saralaya Vasudha
Digito-Palmar Complex In Non-Insulin Dependent Diabetes Mellitus, Vadgaonkar Rajanigandha, Pai Mangala, Prabhu Latha, Saralaya Vasudha
Turkish Journal of Medical Sciences
Background: It is only recently that the knowledge of dermatoglyphics has been applied to the field of medical and genetic diagnosis. Aim: The aim of the present study was to compare and evaluate the dermatoglyphic pattern in individuals with non-insulin dependent diabetes mellitus (NIDDM) with a normal adult population. Materials and Methods: Both quantitative as well as qualitative parameters were analyzed in 112 (63 male and 49 female) subjects and compared with the data from 142 (65 male and 77 female) healthy controls. Modified Purvis-Smith ink method was used for obtaining the prints, and statistical analyses were done using Student's …
Effects Of Ramadan Fasting On Stroke, Selçuk Çomoğlu, Ahmet Temi̇zhan, Emel Peşi̇nci̇, İzzet Tandoğan, Şenay Özbakir
Effects Of Ramadan Fasting On Stroke, Selçuk Çomoğlu, Ahmet Temi̇zhan, Emel Peşi̇nci̇, İzzet Tandoğan, Şenay Özbakir
Turkish Journal of Medical Sciences
The effects of fasting on humans have not been adequately investigated. Ramadan fasting is a great opportunity for scientific research due to its peculiar nature. With this in mind, we conducted research on the effects of Ramadan on stroke, which is one of the most common causes of death in adults. Patients hospitalized solely for ischemic stroke and intracerebral hemorrhage were evaluated retrospectively. The ratio of these cases to other patients hospitalized in the neurology department was determined. The in-hospital clinical course and mortality rates of the patients with stroke were evaluated. Within the entire cohort, the most frequently encountered …
A Cell Protective Mechanism In A Murine Model Of Parkinson's Disease, Emi̇n Öztaş, Turgut Topal
A Cell Protective Mechanism In A Murine Model Of Parkinson's Disease, Emi̇n Öztaş, Turgut Topal
Turkish Journal of Medical Sciences
Parkinson's disease is characterized by progressive degeneration of the dopaminergic (DA) neurons in the substantia nigra (SN). However, the mechanism underlying DA cell death remains unclear. While apoptotic cell death has been implicated in DA cell death in Parkinson's disease, autophagy - a regulated cellular process for degrading intracellular proteins and organelles under stress - in Parkinson's disease is not known. Here, we report evidence of autophagy in DA neurons of the SN in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease. Mice were treated with saline or MPTP (40 mg/kg) and sacrificed after 7 days, and brain tissue samples were …
Lecithin:Cholesterol Acyltransferase Activity And Cholesteryl Ester Transfer Rate In Patients With Diabetes Mellitus, Melahat Di̇ri̇can, Zehra Serdar, Emre Sarandöl, Esma Sürmen Gür
Lecithin:Cholesterol Acyltransferase Activity And Cholesteryl Ester Transfer Rate In Patients With Diabetes Mellitus, Melahat Di̇ri̇can, Zehra Serdar, Emre Sarandöl, Esma Sürmen Gür
Turkish Journal of Medical Sciences
Several factors may be responsible for the high prevalence of atherosclerosis in diabetes mellitus, including alterations in reverse cholesterol transport. In the present study, the activity of plasma lecithin:cholesterol acyltransferase (LCAT) and the cholesteryl ester transfer rate, and concentrations of lipids and lipoproteins were measured in 11 patients with insulin-dependent diabetes mellitus (type 1), 42 patients with noninsulin-dependent diabetes mellitus (type 2) and compared with those in age-matched control groups (Control I, n = 14; and Control II, n = 29, respectively). No statistically significant differences were observed in plasma total cholesterol, triglyceride, ester cholesterol or very low density lipoprotein …
Determination Of Alkaline Phosphatase Activity In Patients With Different Zinc Metabolic Disorders, Zine Kechrid, Rabah Kenouz
Determination Of Alkaline Phosphatase Activity In Patients With Different Zinc Metabolic Disorders, Zine Kechrid, Rabah Kenouz
Turkish Journal of Medical Sciences
Our purpose was to investigate the effect of different zinc metabolic disorders on alkaline phosphatase activity. Serum zinc, glucose and alkaline phosphatase activity were studied in 32 patients with liver cirrhosis, 30 with chronic renal failure and 42 with insulin-dependent diabetes mellitus (IDDM) compared to 42 healthy volunteers. Serum glucose concentration was significantly higher (P < 0.001) in IDDM and liver cirrhosis patients (P < 0.05) compared to the controls. Serum zinc concentrations tended to be lower in all different diseases but did not reach statistical significance. Alkaline phosphatase activity was higher in IDDM (P < 0.05) and liver cirrhosis patients (P < 0.01) compared with the controls. No positive correlation between serum zinc and alkaline phosphatase activity was recorded in any disease. In conclusion, the investigated diseases did not affect the level of serum zinc; however, there was an alteration in alkaline phosphatase activity in patients suffering from diabetes and liver cirrhosis. Consequently, this may be attributed to the functional disturbance that occurred in these patients. Finally, zinc concentration did not follow alkaline phosphatase activity as indicated by the weak correlation obtained.
Effects Of Dietary Salt On Blood Pressure, Heartrate, Extracellular Fluid Volume And Glomerularfiltration Rate In Diabetic Rats, Besi̇m Özaykan, Ayşe Doğan
Effects Of Dietary Salt On Blood Pressure, Heartrate, Extracellular Fluid Volume And Glomerularfiltration Rate In Diabetic Rats, Besi̇m Özaykan, Ayşe Doğan
Turkish Journal of Medical Sciences
In the present study, we aimed to investigate the effects of dietary salt restriction and loading on extracellular fluid volume (ECFV), blood pressure (BP), heart rate (HR), glomerular filtration rate (GFR) and renal hypertrophy in diabetic rats. Diabetes was induced by injection of streptozotocin (STZ, 65 mg/kg, iv) into male Wistar rats. Four groups were formed: a) the diabetic rats given a standard rat diet (DC), b) the diabetic rats given a high-salt diet (DHS), c) the diabetic rats given a low-salt diet (DLS), d) the nondiabetic rats given a standard rat diet (C). Salt loading and salt restriction were …
Diabetic Complications In Experimental Models, Yusuf Öztürk, V. Melih Altan, Nuray Ari
Diabetic Complications In Experimental Models, Yusuf Öztürk, V. Melih Altan, Nuray Ari
Turkish Journal of Medical Sciences
In this review, the aim is to focus on diabetic complications in experimental models of diabetis. For this purpose, com-plications, chiefly seen in log-term periods in various systems of animals, such as cardio vascular and nervous systems, gastrointestinal, urogenital and respiratory tracts, etc., have been stated. Furthermore, novel and conventional therapeutic approaches in their management have also been briefly discussed.