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Full-Text Articles in Medicine and Health Sciences
Redox Signaling In The Zebrafish Embryo And Implications For Endocrine Pancreas Morphogenesis, Archit Rastogi
Redox Signaling In The Zebrafish Embryo And Implications For Endocrine Pancreas Morphogenesis, Archit Rastogi
Doctoral Dissertations
The glutathione (GSH) system evolved to combat oxygen toxicity in nearly all living organisms, and serves as the predominant cellular redox buffer in vertebrates. This dissertation explores the roles of GSH during embryogenesis using the zebrafish (Danio rerio). The first agnostic in vivo characterization of GSH utilization in the embryo revealed strict spatiotemporal GSH profiles in developing organ systems. Interruption of these GSH profiles by exogenous xenobiotics led to organ specific adverse developmental outcomes; pancreatic β-cells were found to be especially susceptible and developed atypical morphologies following redox active xenobiotic exposures. Pancreatic β-cells lacked expression of Nrf2a (Nuclear …
Improving Insomnia With Digital Cognitive Behavioral Therapy In Patients With Diabetes, Patricia Lunardi
Improving Insomnia With Digital Cognitive Behavioral Therapy In Patients With Diabetes, Patricia Lunardi
Doctor of Nursing Practice (DNP) Projects
Background: Managing and treating insomnia in patients with diabetes mellitus requires the examination of current literature of evidence-based research implementing pharmacological and non-pharmacological interventions. This QI project focused on the implementation of Cognitive Behavioral Therapy for Insomnia (CBT-I). Purpose: The purpose of this project was to implement CBT-I in adult patients with diabetes mellitus (DM) and examined whether it alleviated their insomnia symptoms using the Pittsburg Sleep Quality Index (PSQI) tool. Methods: The study used a one-group pre-test and post-test intervention design; the intervention is a free application, “CBT-i Coach”. 20 participants were invited to participate from an Endocrinology …