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Articles 1 - 8 of 8
Full-Text Articles in Medicine and Health Sciences
Redox Signaling In The Zebrafish Embryo And Implications For Endocrine Pancreas Morphogenesis, Archit Rastogi
Redox Signaling In The Zebrafish Embryo And Implications For Endocrine Pancreas Morphogenesis, Archit Rastogi
Doctoral Dissertations
The glutathione (GSH) system evolved to combat oxygen toxicity in nearly all living organisms, and serves as the predominant cellular redox buffer in vertebrates. This dissertation explores the roles of GSH during embryogenesis using the zebrafish (Danio rerio). The first agnostic in vivo characterization of GSH utilization in the embryo revealed strict spatiotemporal GSH profiles in developing organ systems. Interruption of these GSH profiles by exogenous xenobiotics led to organ specific adverse developmental outcomes; pancreatic β-cells were found to be especially susceptible and developed atypical morphologies following redox active xenobiotic exposures. Pancreatic β-cells lacked expression of Nrf2a (Nuclear …
Improving Insomnia With Digital Cognitive Behavioral Therapy In Patients With Diabetes, Patricia Lunardi
Improving Insomnia With Digital Cognitive Behavioral Therapy In Patients With Diabetes, Patricia Lunardi
Doctor of Nursing Practice (DNP) Projects
Background: Managing and treating insomnia in patients with diabetes mellitus requires the examination of current literature of evidence-based research implementing pharmacological and non-pharmacological interventions. This QI project focused on the implementation of Cognitive Behavioral Therapy for Insomnia (CBT-I). Purpose: The purpose of this project was to implement CBT-I in adult patients with diabetes mellitus (DM) and examined whether it alleviated their insomnia symptoms using the Pittsburg Sleep Quality Index (PSQI) tool. Methods: The study used a one-group pre-test and post-test intervention design; the intervention is a free application, “CBT-i Coach”. 20 participants were invited to participate from an Endocrinology …
Cultural And Family Challenges In Type Two Diabetes Self-Care For Puerto Rican Identified Hispanic Adults, Jalil Johnson
Cultural And Family Challenges In Type Two Diabetes Self-Care For Puerto Rican Identified Hispanic Adults, Jalil Johnson
Doctoral Dissertations
ABSTRACT CULTURAL CHALLENGES IN TYPE TWO DIABETES SELF-CARE FOR PUERTO RICAN IDENTIFIED HISPANIC ADULTS FEBRUARY 2019 JALIL A. JOHNSON, B.S.N., MIDDLE TENNESSEE STATE UNIVERSITY M.S., UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL, WORCESTER Ph.D., UNIVERSITY OF MASSACHUSETTS AMHERST Directed by: Dean Stephen Cavanagh Background: Puerto Rican identified Hispanics are disproportionately affected by type 2 diabetes and co-morbid conditions compared to their white counterparts. Culturally tailored interventions improve self-care for Hispanic populations. Interventions should be tailored to the targeted Hispanic subgroup. The intersection of Familism in Puerto Rican culture as it influences type 2 diabetes self-care is not well understood. Research Aims: The …
Improving Latino Diabetes Patients' Physiologic Measurements Utilizing Culturally Competent Interventions, Christine Hoogasian
Improving Latino Diabetes Patients' Physiologic Measurements Utilizing Culturally Competent Interventions, Christine Hoogasian
Doctor of Nursing Practice (DNP) Projects
Latinos have a high risk of developing poorly controlled type 2 diabetes, which may be at least partly due to their cultural beliefs. Many health care clinics lack consistent use of culturally competent educational interventions when providing diabetes education to Latinos. The literature demonstrates that clinics using culturally competent interventions tend to accomplish significant clinical improvements in outcomes such as lower glycosylated hemoglobin (A1C) levels, weight loss, increase in daily steps walked, and improved diabetes knowledge. The purpose of this Doctorate of Nursing Practice (DNP) project was to use Latino-tailored culturally competent diabetes education to achieve a reduction in weight, …
Increasing Exercise For Patients With Diabetes Using A Mobile App – A Quality Improvement Project, Jill Jolin
Increasing Exercise For Patients With Diabetes Using A Mobile App – A Quality Improvement Project, Jill Jolin
Doctor of Nursing Practice (DNP) Projects
Background: A literature review on Type 2 Diabetes Mellitus (T2DM) indicates that a combination of aerobic and resistance exercise leads to overall beneficial physical and psychological health benefits for people that have a diagnosis of Diabetes. Behavior change and social support are identified as essential factors that facilitate and help maintain a productive and committed exercise program for people with Diabetes. Patient self-management is an important indicator in maintaining good control of diabetes, and mobile phone interventions have been shown to improve such self-management. Exercise is an important component of treatment, and prevention of T2DM although people struggle with incorporating …
Higher Fat Low Carbohydrate Diet To Improve Health Related Quality Of Life For Overweight Or Obese Diabetics In A Primary Care Clinic, Breck Baker
Doctor of Nursing Practice (DNP) Projects
Diabetes and obesity are chronic diseases that affect individuals worldwide. The American Diabetes Association (ADA) and the American Heart Association (AHA) have developed guidelines for management of diabetes and obesity. The DNP student examined the use of the Higher Fat Low Carbohydrate (HFLC) diet, which conflicts with these frequently used guidelines. The literature on a HFLC diet suggests positive effects for type 2 diabetics, including weight loss, improved HA1c, lower BMI and no detrimental impact on metabolic markers such as cholesterol, triglycerides, or low and high density lipoproteins. The purpose of this project was to provide type 2 diabetics who …
Improvement Of Functional Bioactivity In Pear:Blackberry Synergies With Lactic Acid Fermentation For Type 2 Diabetes And Hypertension Management, Nicholas W. Pucel
Improvement Of Functional Bioactivity In Pear:Blackberry Synergies With Lactic Acid Fermentation For Type 2 Diabetes And Hypertension Management, Nicholas W. Pucel
Masters Theses 1911 - February 2014
Type II diabetes mellitus (T2DM) is a chronic disease that has a worldwide prevalence which is expected to rise dramatically over the course of the next thirty years. The disease has reached pandemic stages of development in many cultures, most notably in developing countries, followed somewhat closely by developed countries with access to an overabundance of refined carbohydrates and fat (refined oils). T2DM is a condition that can be prevented or managed, but not cured; therefore a method of stymieing the development of this disease is paramount to halting its progressively increasing morbidity. In this study, bartlett pear and kiowa …
Vitamin D Levels And Risk Of Dyslipidemia Among Us Children With Diabetes And Obesity, Elsina E. Hagan
Vitamin D Levels And Risk Of Dyslipidemia Among Us Children With Diabetes And Obesity, Elsina E. Hagan
Masters Theses 1911 - February 2014
Dyslipidemia is increasing among U.S. children, and the prevalence is highest among children with diabetes and obesity. Recently, vitamin D deficiency has been suggested as a possible dietary risk factor for dyslipidemia. Despite the high prevalence of vitamin D deficiency amongst children, virtually no studies have evaluated the association between vitamin D and dyslipidemia among children. We evaluated the vitamin D and dyslipidemia relationship among 240 children and adolescents aged 2 through 21 years who were outpatients of a pediatric endocrinology unit at a large tertiary care facility in Western Massachusetts from April 2008 to April 2010. Eligible children were …