Medicine and Health Sciences Commons^™

Ibuprofen Ameliorates Fatigue- And Depressive-Like Behavior In Tumor-Bearing Mice, Diana M. Norden, Donna O. Mccarthy, Sabahattin Bicer, Raymond Devine, Peter J. Reiser, Jonathan P. Godbout, Loren E. Wold

College of Nursing Faculty Research and Publications

Aims: Cancer-related fatigue (CRF) is often accompanied by depressed mood, both of which reduce functional status and quality of life. Research suggests that increased expression of pro-inflammatory cytokines is associated with skeletal muscle wasting and depressive- and fatigue-like behaviors in rodents and cancer patients. We have previously shown that treatment with ibuprofen, a nonsteroidal anti-inflammatory drug, preserved muscle mass in tumor-bearing mice. Therefore, the purpose of the present study was to determine the behavioral effects of ibuprofen in a mouse model of CRF.

Main methods: Mice were injected with colon-26 adenocarcinoma cells and treated with ibuprofen (10 mg/kg) in the …

Depressive Symptoms And Walking In African‐Americans, Elisa R. Torres, Carolyn M. Sampselle, Harold W. Neighbors, David L. Ronis, Kimberlee A. Gretebeck

College of Nursing Faculty Research and Publications

Objective

Although increased frequency of physical activity is associated with fewer depressive symptoms in African‐Americans, most studies do not focus on a specific type of activity. Identifying the activity can provide helpful information for designing interventions that focus on depressive symptoms. The objective of this study was to examine the odds of depressive symptoms in relation to walking in African‐Americans.

Design and Sample

A secondary analysis was performed on the National Survey of American Life. The sample was made up of community‐dwelling African‐American women (n = 1,903) and men (n = 1,075) who did not meet the DSM‐IV‐TR …

Fluoxetine Prevents The Development Of Depressive-Like Behavior In A Mouse Model Of Cancer Related Fatigue, Diana M. Norden, Raymond Devine, Sabahattin Bicer, Runfeng Jing, Peter J. Reiser, Loren E. Wold, Jonathan P. Godbout, Donna O. Mccarthy

College of Nursing Faculty Research and Publications

Cancer patients frequently suffer from fatigue, a complex syndrome associated with tiredness and depressed mood. Cancer-related fatigue (CRF) can be present at the time of diagnosis, escalates during treatment, and can persist for years after treatment. CRF negatively influences quality of life, limits functional independence, and is associated with decreased survival in patients with incurable disease. We have previously shown that increased pro-inflammatory cytokine expression in the brain contributes to depressive- and fatigue-like behaviors in a mouse model of CRF. Inflammatory cytokines increase the activity of indoleamine 2,3-dioxygenase (IDO) and kynurenine 3-monooxygenase (KMO), which competitively reduce serotonin synthesis. Reduced serotonin …

Tumor Growth Increases Neuroinflammation, Fatigue And Depressive-Like Behavior Prior To Alterations In Muscle Function, Diana M. Norden, Sabahattin Bicer, Yvonne Clark, Runfeng Jing, Christopher J. Henry, Loren E. Wold, Peter J. Reiser, Jonathan P. Godbout, Donna O. Mccarthy

College of Nursing Faculty Research and Publications

Cancer patients frequently suffer from fatigue, a complex syndrome associated with loss of muscle mass, weakness, and depressed mood. Cancer-related fatigue (CRF) can be present at the time of diagnosis, during treatment, and persists for years after treatment. CRF negatively influences quality of life, limits functional independence, and is associated with decreased survival in patients with incurable disease. Currently there are no effective treatments to reduce CRF. The aim of this study was to use a mouse model of tumor growth and discriminate between two main components of fatigue: loss of muscle mass/function and altered mood/motivation. Here we show that …