Medicine and Health Sciences Commons^™

Ibuprofen Ameliorates Fatigue- And Depressive-Like Behavior In Tumor-Bearing Mice, Diana M. Norden, Donna O. Mccarthy, Sabahattin Bicer, Raymond Devine, Peter J. Reiser, Jonathan P. Godbout, Loren E. Wold

College of Nursing Faculty Research and Publications

Aims: Cancer-related fatigue (CRF) is often accompanied by depressed mood, both of which reduce functional status and quality of life. Research suggests that increased expression of pro-inflammatory cytokines is associated with skeletal muscle wasting and depressive- and fatigue-like behaviors in rodents and cancer patients. We have previously shown that treatment with ibuprofen, a nonsteroidal anti-inflammatory drug, preserved muscle mass in tumor-bearing mice. Therefore, the purpose of the present study was to determine the behavioral effects of ibuprofen in a mouse model of CRF.

Main methods: Mice were injected with colon-26 adenocarcinoma cells and treated with ibuprofen (10 mg/kg) in the …

A Model For Hospital Discharge Preparation: From Case Management To Care Transition, Marianne E. Weiss, Kathleen Bobay, Sarah J. Bahr, Linda L. Costa, Ronda G. Hughes, Diane E. Holland

College of Nursing Faculty Research and Publications

There has been a proliferation of initiatives to improve discharge processes and outcomes for the transition from hospital to home and community-based care. Operationalization of these processes has varied widely as hospitals have customized discharge care into innovative roles and functions. This article presents a model for conceptualizing the components of hospital discharge preparation to ensure attention to the full range of processes needed for a comprehensive strategy for hospital discharge.

Increasing Autism Awareness In Inner-City Churches: A Brief Report, Norah L. Johnson, Amy V. Van Hecke

College of Nursing Faculty Research and Publications

Autism diagnosis rates trail significantly in the African American community. This pre-test post-test pilot study evaluated an African American inner-city church health ambassadors (HAs) autism spectrum disorder (ASD) awareness training session. The participants included 12 HAs who attended the 1 hour training session organized by the National Baptist Convention, USA, Inc. Results of surveys showed higher mean scores post training for (1) HA attitudes about the potential for children to improve with applied behavior analysis therapy; (2) HA self-efficacy for having information about ASD screening materials; (3) strategies HAs could use to help parents/caregivers of children with developmental delays and …

The Relationship Of Anti-Mullerian Hormone Levels And Urine Cortisol In Women With Chronic Abdominal Pain, Theresa Hardy, Donna O. Mccarthy, Nicolaas Fourie, Wendy Henderson

College of Nursing Faculty Research and Publications

Context: Persistent and intense stress leads to chronic activation of the hypothalamic-pituitary-adrenal (HPA) axis, placing an individual at increased risk for the development of disease. HPA activity inhibits ovarian functioning, and may contribute to female infertility.

Objective: The objective of the study was to explore the association of HPA activity with ovarian functioning in female participants with and without chronic abdominal pain (CAP).

Design/setting/and subjects: A secondary data analysis was performed using data from female participants in a natural history protocol at the National Institutes of Health. A total of 36 females (19–39 years, mean 27.11) were included in the …

Readiness For Hospital Discharge Scale For Older People: Psychometric Testing And Short Form Development With A Three Country Sample, Cédric Mabire, Alice Coffey, Marianne E. Weiss

College of Nursing Faculty Research and Publications

Aim

To develop and psychometrically test Readiness for Hospital Discharge Scale for older people and to reduce the scale to a more practical short form.

Background

The Readiness for Hospital Discharge Scale is the only available and validated scale measuring patients' perceived readiness just prior to discharge.

Design

Secondary analysis of hospital studies data from three countries.

Method

Data were collected between 2008–2012. The study sample comprised 998 medical-surgical older patients. Factor analysis was undertaken to identify the factor structure of the Readiness for Hospital Discharge Scale. Group comparisons for construct validity and predictive validity for readmission were also conducted. …

Conducting Research With Community Groups, Mary Molewyk Doornbos, Adejoke Ayoola, Gail Landheer Zandee, Robert V. Topp

College of Nursing Faculty Research and Publications

Nurse scientists are increasingly recognizing the necessity of conducting research with community groups to effectively address complex health problems and successfully translate scientific advancements into the community. While several barriers to conducting research with community groups exist, community based participatory research (CBPR) has the potential to mitigate these barriers. CBPR has been employed in programs of research that respond in culturally sensitive ways to identify community needs and thereby address current health disparities. This manuscript presents case studies that demonstrate how CBPR principles guided the development of: (a) a healthy body weight program for urban, underserved African-American women, (b) a …

Bidirectional Psychoneuroimmune Interactions In The Early Postpartum Period Influence Risk Of Postpartum Depression, Elizabeth J. Corwin, Kathleen Pajer, Sudeshna Paul, Nancy Lowe, Mary Weber, Donna O. Mccarthy

College of Nursing Faculty Research and Publications

More than 500,000 U.S. women develop postpartum depression (PPD) annually. Although psychosocial risks are known, the underlying biology remains unclear. Dysregulation of the immune inflammatory response and the hypothalamic–pituitary–adrenal (HPA) axis are associated with depression in other populations. While significant research on the contribution of these systems to the development of PPD has been conducted, results have been inconclusive. This is partly because few studies have focused on whether disruption in the bidirectional and dynamic interaction between the inflammatory response and the HPA axis together influence PPD. In this study, we tested the hypothesis that disruption in the inflammatory-HPA axis …

Models Of Discharge Care In Magnet® Hospitals, Kathleen Bobay, Sarah J. Bahr, Marianne Weiss, Ronda G. Hughes, Linda L. Costa

College of Nursing Faculty Research and Publications

Objective: The aim of this article is to describe how the discharge preparation process is operationalized in Magnet® hospitals.

Background: Nationally, there are intensive efforts toward improving discharge transitions and reducing readmissions. Discharge preparation is a core hospital function, yet there are few reports of operational models.

Methods: This was a descriptive, Web-based survey of 32 Magnet hospitals (64 units) participating in the Readiness Evaluation and Discharge Interventions study.

Results: Most hospitals have adopted 1 or more national readmission reduction initiatives. Most unit models include several discharge preparation roles; RN case managers, and discharging RNs lead …

Resourcefulness In African American And Caucasian American Caregivers Of Persons With Dementia: Associations With Perceived Burden, Depression, Anxiety, Positive Cognitions, And Psychological Well-Being, Abir K. Bekhet

College of Nursing Faculty Research and Publications

Purpose

Providing care to persons with dementia can have negative effects on caregivers' physical and psychological well-being. This secondary analysis explored relationships among perceived burden, depression, anxiety, resourcefulness, and psychological well-being in 28 African American (AA) and 45 Caucasian American (CA) caregivers of persons with dementia.

Design and Methods

Descriptive, cross-sectional design was used to examine the hypothesized relationships in a sample of 73 caregivers.

Findings

CAs reported greater burden (t = −3.68, p < .001), more anxiety (t = −2.66, p < .01), depression (t = −2.21, p < .05), and hostility (t = −2.30, p < .05) than AAs. AAs reported higher scores than CAs on resourcefulness, positive cognitions, and psychological well-being.

Practice Implications

The study findings provided directions for the development of resourcefulness interventions …

Collaborating With Businesses To Support And Sustain Research, Susan Diemert Moch, Debra A. Jansen, Rosemary A. Jadack, Phil Page, Richard Topp

College of Nursing Faculty Research and Publications

Financial assistance is necessary for sustaining research at universities. Business collaborations are a potential means for obtaining these funds. To secure funding, understanding the process for obtaining these business funds is important for nursing faculty members. Although faculty rarely request funding from businesses, they are often in a position to solicit financial support due to existing relationships with clinical agency administrators, staff, and community leaders. The economic support received from businesses provides outcomes in nursing research, research education, academic–service partnerships, and client health care. This article describes the steps and processes involved in successfully obtaining research funding from businesses. In …

Managing Delirium In Hospitalized Older Adults, Margaret J. Bull

College of Nursing Faculty Research and Publications

Consequences of delirium for older adults may include increased mortality, functional decline, nursing home placement, and decreased quality of life. Longer duration of delirium is linked to poorer health outcomes among older adults, underscoring the need for early detection and intervention.

Delirium also exacts a high economic price. Estimated annual U.S. healthcare expenditures range from $143 to $152 billion, with increased hospital stays contributing heavily. Delirium can be frightening for both patients and for family members who observe it in their loved ones. As a nurse, you can play a key role in identifying risk factors, detecting symptoms early, implementing …

Bridges And Barriers: Patients' Perceptions Of The Discharge Process Including Multidisciplinary Rounds On A Trauma Unit, Dawn Zakzesky, Katie Klink, Natalie S. Mcandrew, Kathryn Schroeter, Grace Johnson

College of Nursing Faculty Research and Publications

Discharge planning is a complex process and ideally begins early in the patient stay. Despite evidence about the importance of discharge readiness, there is limited literature about the patient's view during this transition. The goal of this study was to explore patient perspectives about the discharge process, including multidisciplinary rounds. Multidisciplinary rounding is a process where care providers from various specialties meet to communicate, coordinate patient care, make decisions, and manage responsibilities. The theme found was “bridges and barriers to discharge.” Participants identified timelines and tasks, communication, social support, and motivation as helpful and medical setbacks, insurance limitations, and infrequent …

Depressive Symptoms And Walking In African‐Americans, Elisa R. Torres, Carolyn M. Sampselle, Harold W. Neighbors, David L. Ronis, Kimberlee A. Gretebeck

College of Nursing Faculty Research and Publications

Objective

Although increased frequency of physical activity is associated with fewer depressive symptoms in African‐Americans, most studies do not focus on a specific type of activity. Identifying the activity can provide helpful information for designing interventions that focus on depressive symptoms. The objective of this study was to examine the odds of depressive symptoms in relation to walking in African‐Americans.

Design and Sample

A secondary analysis was performed on the National Survey of American Life. The sample was made up of community‐dwelling African‐American women (n = 1,903) and men (n = 1,075) who did not meet the DSM‐IV‐TR …

Depressive Symptoms Affect Working Memory In Healthy Older Adult Hispanics, Mauricio Garnier-Villarreal, Monica Salazar-Villanea, Edward Liebmann, Esteban Montenegro-Montenegro, David K. Johnson

College of Nursing Faculty Research and Publications

Objectives: Low and middle income nations will experience an unprecedented growth of the elderly population and subsequent increase in age-related neurological disorders. Worldwide prevalence and incidence of all-types of neurological disorders with serious mental health complications will increase with life expectancy across the globe. One in ten individuals over 75 has at least moderate cognitive impairment. Prevalence of cognitive impairment doubles every 5 years thereafter. Latin America’s population of older adult’s 65 years and older is growing rapidly, yet little is known about cognitive aging among healthy older Latinos. Clinically significant depressive symptomatology is common among community-dwelling older adults and …

The Influence Of Contraception, Abortion, And Natural Family Planning On Divorce Rates As Found In The 2006–2010 National Survey Of Family Growth, Richard Jerome Fehring

College of Nursing Faculty Research and Publications

The purpose of this study was to determine the influence of contraception, abortion, and natural family planning (NFP) on divorce rates of US women of reproductive age. The variables of importance of religion and frequency of church attendance were also included in the analysis. The study involved 5,530 reproductive age women in the (2006–2010) National Survey of Family Growth who indicate that they were ever married. Among the women who ever used NFP only 9.6 percent were currently divorced compared with the 14.4 percent who were currently divorced among the women who never used NFP (x² = 5.34, …

Predictors Of Engagement In Postpartum Weight Self-Management Behaviours In The First 12 Weeks After Birth, Jennifer Ohlendorf, Marianne E. Weiss, Debra Oswald

College of Nursing Faculty Research and Publications

Aim

To explore factors that influence postpartum weight self-management behaviours. Transitions Theory and the Integrated Theory of Health Behaviour Change guided selection of variables. Transition conditions, level of patient activation and social facilitation were examined for association with postpartum weight self-management behaviours.

Background

Retention of pregnancy weight increases risk of overweight and obesity later in life. Little is known about what women do to self-manage return to pre-pregnant weight and how providers can influence their behaviours.

Design

Prospective, longitudinal, correlational.

Methods

Data collection occurred from March through October, 2013. One hundred and twenty-four women completed surveys during postpartum hospitalization; telephone …

Undergraduate Nursing Students’ Attitudes Toward Mental Health Nursing, Vipavee Thongpriwan, Susan E. Leuck, Rhonda L. Powell, Staci Young, Suzanne Schuler, Ronda G. Hughes

College of Nursing Faculty Research and Publications

Objectives: The purpose of this study was to describe undergraduate nursing students’ attitudes toward mental health nursing and how these attitudes influenced their professional career choices in mental health nursing.

Design: A descriptive, online survey was utilized to examine students’ perceptions of mental health nursing. A total of 229 junior and senior nursing students were recruited from eight nursing colleges in Midwestern United States to participate in this survey.

Results: Students of different ages, genders, ethnicities, and nursing programs did not report significantly different perceptions of: (a) knowledge of mental illness; (b) negative stereotypes; (c) interest in mental health nursing …

Current Medical Research: Summer/Fall 2014, Richard Fehring

College of Nursing Faculty Research and Publications

No abstract provided.

Losartan Treatment Attenuates Tumor-Induced Myocardial Dysfunction, Sarah C.W. Stevens, Markus Velten, Dane J. Youtz, Yvonne Clark, Runfeng Jing, Peter J. Reiser, Sabahattin Bicer, Raymond D. Devine, Donna O. Mccarthy, Loren E. Wold

College of Nursing Faculty Research and Publications

Fatigue and muscle wasting are common symptoms experienced by cancer patients. Data from animal models demonstrate that angiotensin is involved in tumor-induced muscle wasting, and that tumor growth can independently affect myocardial function, which could contribute to fatigue in cancer patients. In clinical studies, inhibitors of angiotensin converting enzyme (ACE) can prevent the development of chemotherapy-induced cardiovascular dysfunction, suggesting a mechanistic role for the renin–angiotensin–aldosterone system (RAAS). In the present study, we investigated whether an angiotensin (AT) 1-receptor antagonist could prevent the development of tumor-associated myocardial dysfunction. Methods and results: Colon26 adenocarcinoma (c26) cells were implanted into female CD2F1 mice …

Psychometric Properties Of The Family Caregiver Delirium Knowledge Questionnaire, Margaret J. Bull, Jennifer M. Sjostedt, Lesley Boaz, Debra Oswald

College of Nursing Faculty Research and Publications

A valid, reliable measure of family caregivers’ knowledge about delirium was not located in the literature; such an instrument is essential to assess learning needs and outcomes of education provided. The purpose of the current study was to (a) develop a family Caregiver Delirium Knowledge Questionnaire (CDKQ) based on the Symptom Interpretation Model; and (b) establish validity and reliability of the measure. The 19-item CDKQ was developed and administered to 164 family caregivers for community-dwelling older adults. Descriptive statistics were examined for all variables. Psychometric testing included confirmatory factor analysis, item-to-total correlations, and internal consistency reliability. A three-factor model provided …

Emerging Areas Of Nursing Science And Phd Education For The 21St Century: Response To Commentaries, Susan J. Henly, Donna O. Mccarthy, Jean F. Wyman, Anna C. Alt-White, Patricia W. Stone, Ann Marie Mccarthy, Nancy S. Redeker, Jacqueline Dunbar-Jacob, Marita Titler, Marita G. Titler, Yvette P. Conley, Margaret M. Heitkemper, Shirley M. Moore

College of Nursing Faculty Research and Publications

We respond to commentaries from the American Academy of Nursing, the American Association of Colleges of Nursing, and the National Institute of Nursing Research on our thoughts about integrating emerging areas of science into nursing PhD programs. We identify areas of agreement and focus our response on cross-cutting issues arising from cautions about the unique focus of nursing science and how best to proceed with incorporation of emerging areas of science into nursing PhD programs.

Integrating Emerging Areas Of Nursing Science Into Phd Programs, Susan J. Henly, Donna O. Mccarthy, Jean F. Wyman, Patricia W. Stone, Nancy S. Redeker, Ann Marie Mccarthy, Jacqueline Dunbar-Jacob, Marita Titler, Shirley M. Moore, Margaret M. Heitkemper, Yvette P. Conley

College of Nursing Faculty Research and Publications

The Council for the Advancement of Nursing Science aims to “facilitate and recognize life-long nursing science career development” as an important part of its mission. In light of fast-paced advances in science and technology that are inspiring new questions and methods of investigation in the health sciences, the Council for the Advancement of Nursing Science convened the Idea Festival for Nursing Science Education and appointed the Idea Festival Advisory Committee to stimulate dialogue about linking PhD education with a renewed vision for preparation of the next generation of nursing scientists. Building on the 2010 American Association of Colleges of Nursing …

Emerging Areas Of Science: Recommendations For Nursing Science Education From The Council For The Advancement Of Nursing Science Idea Festival, Susan J. Henly, Donna O. Mccarthy, Jean F. Wyman, Margaret M. Heitkemper, Nancy S. Redeker, Marita Titler, Ann Marie Mccarthy, Patricia W. Stone, Shirley M. Moore, Anna C. Alt-White, Yvette P. Conley

College of Nursing Faculty Research and Publications

The Council for the Advancement of Nursing Science aims to “facilitate and recognize life-long nursing science career development” as an important part of its mission. In light of fast-paced advances in science and technology that are inspiring new questions and methods of investigation in the health sciences, the Council for the Advancement of Nursing Science convened the Idea Festival for Nursing Science Education and appointed the Idea Festival Advisory Committee (IFAC) to stimulate dialogue about linking PhD education with a renewed vision for preparation of the next generation of nursing scientists. Building on the 2005 National Research Council report Advancing …

Educating Future Nursing Scientists: Recommendations For Integrating Omics Content In Phd Programs, Margaret M. Heitkemper, Donna O. Mccarthy, Cindy M. Anderson, Elizabeth J. Corwin, Sandra Daack-Hirsch, Susan G. Dorsey, Katherine E. Gregory, Maureen W. Groer, Susan J. Henly, Timothy Landers, Debra E. Lyon, Jacquelyn Y. Taylor, Joachim Voss

College of Nursing Faculty Research and Publications

Preparing the next generation of nursing scientists to conduct high-impact, competitive, sustainable, innovative, and interdisciplinary programs of research requires that the curricula for PhD programs keep pace with emerging areas of knowledge and health care/biomedical science. A field of inquiry that holds great potential to influence our understanding of the underlying biology and mechanisms of health and disease is omics. For the purpose of this article, omics refers to genomics, transcriptomics, proteomics, epigenomics, exposomics, microbiomics, and metabolomics. Traditionally, most PhD programs in schools of nursing do not incorporate this content into their core curricula. As part of the Council for …

Weight Loss Intervention Efficacy Among Black Women, Callie Chiroff, Kristin Haglund

College of Nursing Faculty Research and Publications

Obesity is a complex disease state that has challenged the health of Americans and has become a main concentration in health care. The highest rates of obesity are observed among black women. The purpose of this evidence-based review was to find evidence that specifically examined black women to determine if participation in weight loss interventions led to successful weight loss compared with usual care and control groups. Twelve experimental studies and 4 systematic reviews revealed that interventions contributed to successful weight loss among black women with obesity. However, maintenance of weight loss is an ongoing challenge.

“Not Being Able To Talk Was Horrid”: A Descriptive, Correlational Study Of Communication During Mechanical Ventilation, Jill L. Guttormson, Karin Lindstrom Bremmer, Rachel M. Jones

College of Nursing Faculty Research and Publications

Objectives: The purpose of this study was to describe the patient experience of communication during mechanical ventilation.

Research methodology: This descriptive study is a secondary analysis of data collected to study the relationship between sedation and the MV patients’ recall of the ICU. Interviews, conducted after extubation, included the Intensive Care Experience Questionnaire. Data were analysed with Spearman correlation coefficients (r_s) and content analysis.

Setting: Participants were recruited from a medical-surgical intensive care unit in the Midwest United States.

Results: Participants (n = 31) with a mean age of 65 ± 11.9 were on the …

Anesthesia Preoperative Clinic Referral For Elevated Hba1c Reduces Complication Rate In Diabetic Patients Undergoing Total Joint Arthroplasty, Peter J. Kallio, Jenea Nolan, Amy C. Olsen, Susan Breakwell, Richard Topp, Paul S. Pagel

College of Nursing Faculty Research and Publications

Background: Diabetes mellitus (DM) is risk factor for complications after orthopedic surgery.

Objectives: We tested the hypothesis that anesthesia preoperative clinic (APC) referral for elevated glycosylated hemoglobin (HbA1c) reduces complication rate after total joint arthroplasty (TJA).

Patients and Methods: Patients (n = 203) with and without DM were chosen from 1,237 patients undergoing TJA during 2006 - 12. Patients evaluated in the APC had surgery in 2006 - 8 regardless of HbA1c (uncontrolled). Those evaluated between in subsequent two-year intervals were referred to primary care for HbA1c ≥ 10% and ≥ 8%, respectively, to improve DM control before surgery. Complications …

Trauma Nurses: Making A Difference, Kathryn Schroeter

College of Nursing Faculty Research and Publications

No abstract provided.

Ubiquinol Reduces Muscle Wasting But Not Fatigue In Tumor-Bearing Mice, Yvonne Clark, Loren E. Wold, Laura A. Szalacha, Donna O. Mccarthy

College of Nursing Faculty Research and Publications

Purpose: Fatigue is the most common and distressing symptom reported by cancer patients during and after treatment. Tumor growth increases oxidative stress and cytokine production, which causes skeletal muscle wasting and cardiac dysfunction. The purpose of this study was to determine whether treatment with the antioxidant ubiquinol improves muscle mass, cardiac function, and behavioral measures of fatigue in tumor-bearing mice.

Method: Adult female mice were inoculated with colon26 tumor cells. Half the control and tumor-bearing mice were administered ubiquinol (500 mg/kg/day) in their drinking water. Voluntary wheel running (i.e., voluntary running activity [VRA]) and grip strength were measured at Days …

Getting Started With Debriefing For Meaningful Learning, Kristina Dreifuerst

College of Nursing Faculty Research and Publications

Debriefing for Meaningful Learning© (DML) is a method of debriefing that can be used in simulation environments and other clinical settings to foster student's reflective thinking and learning. It has been used successfully with prelicensure nursing students, graduate nursing students, and interdisciplinary health care students throughout the nursing curriculum with positive learning outcomes. This method can be challenging to learn because it uses Socratic questioning and principles of active learning to uncover thinking associated with actions, but once learned, DML can be a model for reflective thinking that students can use to develop clinical reasoning and become reflective practitioners. Moreover, …