Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Institution
- Publication
- Publication Type
Articles 1 - 10 of 10
Full-Text Articles in Medicine and Health Sciences
Human West Nile Virus Disease Outbreak In Pakistan, 2015–2016, E. Khan, Kelli L. Barr, Joveria Farooqi, Dhani Prakoso, Alizae Abbas, Zain Y. Khan, Shanze Ashi, Kehkashan Imtiaz, Z Aziz, Faisal Malik
Human West Nile Virus Disease Outbreak In Pakistan, 2015–2016, E. Khan, Kelli L. Barr, Joveria Farooqi, Dhani Prakoso, Alizae Abbas, Zain Y. Khan, Shanze Ashi, Kehkashan Imtiaz, Z Aziz, Faisal Malik
Department of Pathology and Laboratory Medicine
Like most of the world, Pakistan has seen an increase in mosquito-transmitted diseases in recent years. The magnitude and distribution of these diseases are poorly understood as Pakistan does not have a nation-wide system for reporting disease. A cross-sectional study to determine which flaviviruses were causing of arboviral disease in Pakistan was instituted. West Nile virus (WNV) is a cause of seasonal fever with neurotropic findings in countries that share borders with Pakistan. Here, we describe the active and persistent circulation of WNV in humans in the southern region of Pakistan. This is the first report of WNV causing neurological …
Dengue, Edward Ramos
Dengue, Edward Ramos
Global Issues in Public Health
The dengue virus puts one third of the world’s population at risk. Humans carry the virus and mosquitoes pick it up and are able to spread to more people. As long as there are mosquitoes near you there is the possibility that you could become infected with the dengue virus. However, people living in tropical areas that are poverty stricken are much more likely to bit by these mosquitoes and developed dengue fever. Things like mosquito netting and proper plumbing help lower the amount of these mosquitoes from biting people. There are very few treatments for when a person gets …
Molecular Evolution Of Dengue Type 2 Virus In Thailand, Rebeca Rico-Hesse, Lisa M. Harrison, Ananda Nisalak, David W. Vaughn, Siripen Kalayanarooj, Sharone Green, Alan L. Rothman, Francis A. Ennis
Molecular Evolution Of Dengue Type 2 Virus In Thailand, Rebeca Rico-Hesse, Lisa M. Harrison, Ananda Nisalak, David W. Vaughn, Siripen Kalayanarooj, Sharone Green, Alan L. Rothman, Francis A. Ennis
Sharone Green
Dengue is a mosquito-borne viral infection that in recent years has become a major international public health concern. Dengue hemorrhagic fever (DHF), first recognized in Southeast Asia in the 1950s, is today a leading cause of childhood death in many countries. The pathogenesis of this illness is poorly understood, mainly because there are no laboratory or animal models of disease. We have studied the genetic relationships of dengue viruses of serotype 2, one of four antigenically distinct dengue virus groups, to determine if viruses obtained from cases of less severe dengue fever (DF) have distinct evolutionary origins from those obtained …
Blood Meal Acquisition Enhances Arbovirus Replication In Mosquitoes Through Activation Of The Gabaergic System, Y Zhu, R Zhang, B Zhang, T Zhao, Penghua Wang, G Liang, G Cheng
Blood Meal Acquisition Enhances Arbovirus Replication In Mosquitoes Through Activation Of The Gabaergic System, Y Zhu, R Zhang, B Zhang, T Zhao, Penghua Wang, G Liang, G Cheng
NYMC Faculty Publications
Mosquitoes are hematophagous insects that carry-on and transmit many human viruses. However, little information is available regarding the common mechanisms underlying the infection of mosquitoes by these viruses. In this study, we reveal that the hematophagous nature of mosquitoes contributes to arboviral infection after a blood meal, which suppresses antiviral innate immunity by activating the GABAergic pathway. dsRNA-mediated interruption of the GABA signaling and blockage of the GABAA receptor by the specific inhibitors both significantly impaired arbovirus replication. Consistently, inoculation of GABA enhanced arboviral infection, indicating that GABA signaling facilitates the arboviral infection of mosquitoes. The ingestion of blood by …
Increasing Usage Of Rapid Diagnostics For Dengue Virus Detection In Pakistan, Zahra Hasan, Saher Razzak, Muhammad Farhan, Maryam Rahim, Nazneen Islam, Azra Samreen, E. Khan
Increasing Usage Of Rapid Diagnostics For Dengue Virus Detection In Pakistan, Zahra Hasan, Saher Razzak, Muhammad Farhan, Maryam Rahim, Nazneen Islam, Azra Samreen, E. Khan
Department of Pathology and Laboratory Medicine
No abstract provided.
Relationships Between Dengue Virus Infection In Mosquito Vector, (Aedes Aegypti), Dengue Cases And Weather Conditions In Samut Sakhon Province, Thailand, Veerayuth Kittichai, Prakaikaew Montriwat, Jakkrawarn Chompoosri, Payu Bhakdeenuan, Theerakamol Pengsakul, Apiwat Tawatsin, Usavadee Thavara, Padet Siriyasatien
Relationships Between Dengue Virus Infection In Mosquito Vector, (Aedes Aegypti), Dengue Cases And Weather Conditions In Samut Sakhon Province, Thailand, Veerayuth Kittichai, Prakaikaew Montriwat, Jakkrawarn Chompoosri, Payu Bhakdeenuan, Theerakamol Pengsakul, Apiwat Tawatsin, Usavadee Thavara, Padet Siriyasatien
Chulalongkorn Medical Journal
Background : Dengue is commonly found in the tropical and subtropical regions.The disease is still affecting the population of the world especially inSoutheast Asia. The current increase in both morbidity and mortalityrates was associated with the potentiality of the viral transmission.Surveillance focusing on the virus infection in principal dengue vector,weather conditions and number of dengue cases should be evaluatedto develop an effective control approach, therefore reducethe emergence of dengue disease within the endemic and/or new areas.Objectives : To characterize the transmission pattern of dengue virus in the mosquitovector (Aedes aegypti) according to the seasons and to determinethe relationship between dengue …
A Global Compendium Of Human Dengue Virus Occurrence, Jane P. Messina, Oliver J Brady, David M. Pigott, John S. Brownstein, Anne Hoen, Simon Hay
A Global Compendium Of Human Dengue Virus Occurrence, Jane P. Messina, Oliver J Brady, David M. Pigott, John S. Brownstein, Anne Hoen, Simon Hay
Dartmouth Scholarship
A global geographic database of human dengue virus occurrence was produced to generate a global risk map and associated burden estimates1. Herein we present the database, which comprises occurrence data linked to point or polygon locations, derived from peer-reviewed literature and case reports as well as informal online sources. Entries date from 1960 to 2012. We describe all data collection processes in full, as well as geo-positioning, database management and quality-control procedures. This is the most comprehensive database of confirmed human dengue infection to-date, consisting of 8,309 geo-positioned occurrences in total.
A Dna Microarray-Based Assay To Detect Dual Infection With Two Dengue Virus Serotypes, Alvaro Diaz-Badillo, María De Lourdes Muñoz, Gerardo Pérez-Ramírez, Victor Altuzar, Juan Burgueño, Julio G. Mendoza-Alvarez, Jorge P. Martínez-Muñoz, Alejandro Cisneros, Joel Navarrete-Espinosa, Feliciano Sanchez-Sinencio
A Dna Microarray-Based Assay To Detect Dual Infection With Two Dengue Virus Serotypes, Alvaro Diaz-Badillo, María De Lourdes Muñoz, Gerardo Pérez-Ramírez, Victor Altuzar, Juan Burgueño, Julio G. Mendoza-Alvarez, Jorge P. Martínez-Muñoz, Alejandro Cisneros, Joel Navarrete-Espinosa, Feliciano Sanchez-Sinencio
School of Medicine Publications and Presentations
Here; we have described and tested a microarray based-method for the screening of dengue virus (DENV) serotypes. This DNA microarray assay is specific and sensitive and can detect dual infections with two dengue virus serotypes and single-serotype infections. Other methodologies may underestimate samples containing more than one serotype. This technology can be used to discriminate between the four DENV serotypes. Single-stranded DNA targets were covalently attached to glass slides and hybridised with specific labelled probes. DENV isolates and dengue samples were used to evaluate microarray performance. Our results demonstrate that the probes hybridized specifically to DENV serotypes; with no detection …
Identification Of Claudin-1 As An Entry Factor In Dengue Infection And Development Of A High Throughput Screening Assay For Antivirals Against Dengue Virus, Pulin Che
All ETDs from UAB
Dengue virus (DENV) has become a huge public health concern around the world with no vaccine or antivirals available. More than one-third of the world's population is living in areas at risk of infection. To conquer the dengue disease, a better understanding of virus-host interactions and development of the appropriate therapeutic treatments are required. In this dissertation, we first broadly reviewed the factors involved in dengue viral entry and the role of tight junctions as a pathogen target. Second, we developed, optimized and validated a high throughput screening (HTS) assay for anti-dengue virus drug screening. Taking advantage of using live …
Dengue Virus Serotype 3, Karachi, Pakistan, Bushra Jamil, Rumina Hasan, Afia Zafar, Kevin Bewley, John Chamberlain, Valerie Mioulet, Moira Rowlands, Roger Hewson
Dengue Virus Serotype 3, Karachi, Pakistan, Bushra Jamil, Rumina Hasan, Afia Zafar, Kevin Bewley, John Chamberlain, Valerie Mioulet, Moira Rowlands, Roger Hewson
Department of Medicine
No abstract provided.