Medicine and Health Sciences Commons^™

Role Of Endosialin/Cd248 And Cytoglobin In Liver Fibrosis, Mahmoud Abdallah Mansour, Khaled Abd Elazeme Eid, Ashraf Mohamed Elkabeer, Eglal Mohamed Kenawy, Bakheet Elkot Mostafa Elsadek

Al-Azhar International Medical Journal

Background - Chronic liver diseases are a major global health burden. CYGB, Human IV globin is abundantly expressed in Hepatic Stellate Cell(HSCs) between hepatocytes. CYGB can bind oxygen and nitric oxide and is said to protect HSCs from reactive oxygen species(ROS).

Aim - to estimate role of CD248 and Cygb in process of liver fibrosis.

Patients and Methods - This study was conducted on forty-four Egyptian patients with hepatic stenosis detected by ultrasound, and forty healthy volunteers as control group.

Results - Our results showed statistical significant (p-value < 0.001) increased CD248 in patients group (189.03 ± 66.6) when compared with control group (138.7 ± 36.5), decreased Cygb in patients group (1.62 ± 0.35) when compared with control group (1.93 ± 0.26)

Conclusion - Our study identified Cygb and CD248 …

The Impact Of The Covid-19 Pandemic On Patients With Chronic Liver Disease: Results From The Global Liver Registry, Zobair M. Younossi, Yusuf Yilmaz, Mohamed El-Kassas, Ajay Duseja, Saeed Hamid, Gamal Esmat, Nahum Méndez-Sánchez, Wah Kheong Chan, Ashwani K. Singal, Brian Lam

Department of Medicine

Patients with preexisting chronic liver disease (CLD) may experience a substantial burden from both coronavirus 2019 (COVID-19) infection and pandemic-related life disruption. We assessed the impact of the COVID-19 pandemic on patients with CLD. Patients enrolled in our Global Liver Registry were invited to complete a COVID-19 survey. As of June 2021, 2500 patients (mean age ± SD, 49 ± 13 years; 53% men) from seven countries completed the survey. Of all survey completers, 9.3% had COVID-19. Of these patients, 19% were hospitalized, 13% needed oxygen support, but none required mechanical ventilation. Of all patients including those not infected with …

Portal Hypertension, Kristi Loomis

Nursing Student Class Projects (Formerly MSN)

Chronic liver disease plagues the body with many significant complications. One of the more commonly identified complications is portal hypertension (PHT). Without intervention the elevated pressures in PHT will lead to extensive complications, and eventually death

Therapeutic Efficacy Of L-Ornithine L-Aspartate In Patients With Hepatic Encephalopathy, Fadieleh Aidrus, Salma Razzaque, Afshan Siddiqui, Ajeet Kumar, M. Ishaq Ghaur

Pakistan Journal of Neurological Sciences (PJNS)

To determine the efficacy of ornithine-aspartate in reducing blood ammonia levels and clinical improvement, as a part of treatment in hepatic encephalopathy. Material & method: A randomized placebo controlled trial was conducted in 2013 in Jinnah medical and dental college hospital Korangi Karachi. One hundred patients with hepatic encephalopathy due to underlying chronic liver disease were randomly assigned into two groups with 50 patients each. One group received three days of ornithine-aspartate infusions (trial-treatment group) and the other group received three days of infusion of placebo (placebo group). Serum ammonia was measured in both groups on day 1 and day …

Nash: Non-Alcoholic Steatohepatitis, Jennifer Heck

Nursing Student Class Projects (Formerly MSN)

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease which refers to the presence of hepatic steatosis without significant intake of alcohol. Non-alcoholic fatty liver disease develops in a variety of forms from reversible simple steatosis to non-alcoholic steatohepatitis (NASH), which if left unchecked can progress to liver fibrosis, cirrhosis and even develop into hepatocellular carcinoma (Mells et al., 2014). NAFLD is thought to be nonthreatening, but with progression over several years could lead to NASH. A strong link between obesity and NASH has been shown. In addition to obesity, insulin resistance (type II diabetes mellitus), and hyperlipidemia all …

Precipitating Factors Of Hepatic Encephalopathy In Patients With Chronic Liver Disease At Civil Hospital Karachi, Dileep K Rohra, Jaipal, Ameer A Khowaja, Khalid Mahmood, Kanya Lal Ahuja

Department of Biological & Biomedical Sciences

No abstract provided.

Precipitating Factors And The Outcome Of Hepatic Encephalopathy In Liver Cirrhosis., Dileep K. Rohra, Jaipal, Ameer A. Khowaja, Khalid Mahmood, Kanya Lal Ahuja

Department of Medicine

No abstract provided.

Depression, Anxiety, Hazardous Drinking, Subjective Burden, And Rewards In Family Caregivers Of Patients With Chronic Liver Disease, Lois Vennesta Bolden

Theses and Dissertations (ETD)

This descriptive correlation study had three purposes. The study first described depressive and anxiety symptom levels, prevalence of hazardous drinking, rewards, and subjective burden reported by family caregivers of patients with chronic liver disease (CLD). Second, the investigator compared depressive and anxiety symptom levels, prevalence of hazardous drinking, rewards, and subjective burden reported by African Americans family caregivers with those reported by Caucasian family caregivers of patients with CLD. The third purpose was to determine the predictors of subjective burden and mental health status of family caregivers of persons with CLD.

A convenience sample of 73 caregivers of patients receiving …

Dietary Practices And Beliefs Of Patients With Chronic Liver Disease, S H. Badruddin, S M. Jafri, A Ahmed, S Abid

Section of Diabetes, Endocrinology and Metabolism

Objective: To study of the dietary practices and beliefs of patients suffering from chronic liver disease.

Setting: Two private tertcary care hospitals.

Method: Fifty patients presenting to the Gastroenterology Clinics at the Aga Khan University Hospital and Baqai Hospital, with compensated liver disease and no other co-morbid condition which required dietary modifications, were enrolled in the study. Patients were interviewed regarding their current dietary practices using an open-ended questionnaire.

Results: The mean age of the patients was 48 years and the majority were in relatively poor nutritional status. Four had BMI's < 18; 58% had Hb < 12 g/dl and 36% had albumin levels < 3 gm/dl. The percentage of patients avoiding various foods is as follows: meats 72%, fats and oils 64%, salt 42%, spices 34%, milk and milk products 28%, rice 20%.

Conclusion: The most commonly cited reason for avoiding a …